| 1 | Sun Nov 29 | at UNC Greensboro | PPD | 23-2 | .920 | - | | KFC Yum! Center · Louisville, KY |
| 2 | Tue Dec 1 | atUNC Greensboro | W75-67 | 1-0 | 1.000 | - | | KFC Yum! Center · Louisville, KY |
| 3 | Thu Dec 3 | atLittle Rock | W80-75 | 2-0 | 1.000 | - | | KFC Yum! Center · Louisville, KY |
| 5 | Sat Dec 12 | atSC Upstate | W95-77 | 3-0 | 1.000 | - | | G.B. Hodge Center · Spartanburg, SC |
| 6 | Sun Dec 13 | atSC Upstate | W107-77 | 4-0 | 1.000 | - | | G.B. Hodge Center · Spartanburg, SC |
| 7 | Sat Dec 19 | vsFurman | W87-71 | 5-0 | 1.000 | - | | Winthrop Coliseum · Rock Hill, SC |
| 8 | Wed Dec 30 | vsCampbell | W84-83 | 6-0 | 1.000 | - | | Winthrop Coliseum · Rock Hill, SC |
| 9 | Thu Dec 31 | vsCampbell | W94-76 | 7-0 | 1.000 | - | | Winthrop Coliseum · Rock Hill, SC |
| 10 | Mon Jan 4 | atCharleston So | W85-69 | 8-0 | 1.000 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 11 | Tue Jan 5 | atCharleston So | W78-76 | 9-0 | 1.000 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 12 | Sat Jan 9 | vsGardner-Webb | W75-65 | 10-0 | 1.000 | - | | Winthrop Coliseum · Rock Hill, SC |
| 13 | Sat Jan 9 | atHigh Point | PPD | 23-2 | .920 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 14 | Sun Jan 10 | vsGardner-Webb | W91-83 | 11-0 | 1.000 | - | | Winthrop Coliseum · Rock Hill, SC |
| 15 | Sun Jan 10 | atHigh Point | PPD | 23-2 | .920 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 16 | Thu Jan 14 | vsLongwood | W72-61 | 12-0 | 1.000 | - | ESPNU | Winthrop Coliseum · Rock Hill, SC |
| 17 | Fri Jan 15 | vsLongwood | W70-50 | 13-0 | 1.000 | - | | Winthrop Coliseum · Rock Hill, SC |
| 18 | Tue Jan 19 | atPresbyterian | W72-58 | 14-0 | 1.000 | - | ESPNU | Ross E. Templeton P.E. Center · Clinton, SC |
| 19 | Wed Jan 20 | atPresbyterian | W78-66 | 15-0 | 1.000 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 22 | Thu Jan 28 | vsUNC Asheville | W84-80 | 16-0 | 1.000 | - | ESPNU | Winthrop Coliseum · Rock Hill, SC |
| 23 | Fri Jan 29 | vsUNC Asheville | L55-57 | 16-1 | .941 | - | | Winthrop Coliseum · Rock Hill, SC |
| 24 | Thu Feb 11 | atRadford | W80-64 | 17-1 | .944 | - | | Donald N. Dedmon Center · Radford, VA |
| 25 | Fri Feb 12 | atRadford | W55-47 | 18-1 | .947 | - | | Donald N. Dedmon Center · Radford, VA |
| 26 | Thu Feb 18 | atHigh Point | W76-70 | 19-1 | .950 | - | ESPNU | Nido and Mariana Qubein Arena · High Point, NC |
| 27 | Fri Feb 19 | atHigh Point | W71-63 | 20-1 | .952 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 29 | Mon Mar 1 | vsHigh Point | W83-54 | 21-1 | .955 | - | | Winthrop Coliseum · Rock Hill, SC |
| 30 | Thu Mar 4 | vsLongwood | W82-61 | 22-1 | .957 | - | | Winthrop Coliseum · Rock Hill, SC |
| 31 | Sun Mar 7 | vsCampbell | W80-53 | 23-1 | .958 | - | ESPN | Winthrop Coliseum · Rock Hill, SC |
| 32 | Fri Mar 19 | at#5Villanova | L63-73 | 23-2 | .920 | #12 | TNT | Indiana Farmers Coliseum · Indianapolis, IN |
