| Mon Nov 4 | vs Lafayette | 12:00 AM | 11-21 | .344 | Finneran Pavilion · Villanova, PA |
| Wed Nov 6 | vs Columbia | 12:00 AM | 13-14 | .481 | Finneran Pavilion · Villanova, PA |
| Fri Nov 8 | vs NJIT | 12:00 AM | 7-21 | .250 | Finneran Pavilion · Villanova, PA |
| Tue Nov 12 | at Saint Joseph's | 12:00 AM | 21-14 | .600 | Michael J. Hagan '85 Arena · Philadelphia, PA |
| Fri Nov 15 | vs Virginia | 12:00 AM | 23-11 | .676 | Finneran Pavilion · Villanova, PA |
| Tue Nov 19 | vs Penn | 12:00 AM | 11-18 | .379 | Finneran Pavilion · Villanova, PA |
| Sun Nov 24 | at Maryland | 1:00 PM | 16-17 | .485 | XFINITY Center · College Park, MD |
| Wed Nov 27 | vs Rider | 12:00 AM | 15-17 | .469 | Finneran Pavilion · Villanova, PA |
| Tue Dec 3 | vs Cincinnati | 12:00 AM | 22-15 | .595 | Finneran Pavilion · Villanova, PA |
| Wed Dec 11 | vs Fairleigh | 12:00 AM | 15-17 | .469 | Finneran Pavilion · Villanova, PA |
| Tue Dec 17 | vs Seton Hall | 12:00 AM | 25-12 | .676 | Finneran Pavilion · Villanova, PA |
| Sat Dec 21 | at Creighton | 12:00 AM | 25-10 | .714 | CHI Health Center Omaha · Omaha, NE |
| Wed Jan 1 | at Butler | 12:00 AM | 18-15 | .545 | Hinkle Fieldhouse · Indianapolis, IN |
| Sat Jan 4 | vs DePaul | 12:00 AM | 3-29 | .094 | Finneran Pavilion · Villanova, PA |
| Wed Jan 8 | vs UConn | 12:00 AM | 37-3 | .925 | Finneran Pavilion · Villanova, PA |
| Sat Jan 11 | at St John's | 12:00 AM | 20-13 | .606 | Carnesecca Arena · Queens, NY |
| Tue Jan 14 | at Xavier | 12:00 AM | 16-18 | .471 | Cintas Center · Cincinnati, OH |
| Fri Jan 17 | vs Providence | 12:00 AM | 21-14 | .600 | Finneran Pavilion · Villanova, PA |
| Mon Jan 20 | vs Georgetown | 12:00 AM | 9-23 | .281 | Finneran Pavilion · Villanova, PA |
| Fri Jan 24 | at Marquette | 12:00 AM | 27-10 | .730 | Fiserv Forum · Milwaukee, WI |
| Sat Feb 1 | vsCreighton | 12:00 AM | 25-10 | .714 | Finneran Pavilion · Villanova, PA |
| Wed Feb 5 | atDePaul | 12:00 AM | 3-29 | .094 | Wintrust Arena · Chicago, IL |
| Sun Feb 9 | vsXavier | 12:00 AM | 16-18 | .471 | Finneran Pavilion · Villanova, PA |
| Wed Feb 12 | vsSt John's | 12:00 AM | 20-13 | .606 | Finneran Pavilion · Villanova, PA |
| Sat Feb 15 | atProvidence | 12:00 AM | 21-14 | .600 | Amica Mutual Pavilion · Providence, RI |
| Tue Feb 18 | atUConn | 12:00 AM | 37-3 | .925 | Gampel Pavilion · Storrs, CT |
| Fri Feb 21 | vsMarquette | 12:00 AM | 27-10 | .730 | Finneran Pavilion · Villanova, PA |
| Wed Feb 26 | atSeton Hall | 12:00 AM | 25-12 | .676 | Prudential Center · Newark, NJ |
| Sat Mar 1 | vsButler | 12:00 AM | 18-15 | .545 | Finneran Pavilion · Villanova, PA |
| Tue Mar 4 | atGeorgetown | 12:00 AM | 9-23 | .281 | Capital One Arena · Washington, D.C. |
