| 8 | Sat Dec 6 | vs Penn | 7:30 PM | 5-3 | .625 | - | | Finneran Pavilion · Villanova, PA |
| 9 | Tue Dec 9 | at#3Michigan | 6:30 PM | 7-0 | 1.000 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 10 | Sat Dec 13 | vsPitt | 4:30 PM | 5-4 | .556 | - | TNT | Finneran Pavilion · Villanova, PA |
| 11 | Fri Dec 19 | vsWisconsin | 8:00 PM | 6-2 | .750 | - | FOX | Fiserv Forum · Milwaukee, WI |
| 12 | Tue Dec 23 | atSeton Hall | 7:00 PM | 8-1 | .889 | - | Peacock | Prudential Center · Newark, NJ |
| 13 | Wed Dec 31 | vsDePaul | 6:00 PM | 5-3 | .625 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 14 | Sat Jan 3 | atButler | 12:00 PM | 7-1 | .875 | - | TNT | Hinkle Fieldhouse · Indianapolis, IN |
| 15 | Wed Jan 7 | vsCreighton | 7:30 PM | 5-3 | .625 | - | | Finneran Pavilion · Villanova, PA |
| 16 | Sat Jan 10 | atMarquette | 2:30 PM | 5-4 | .556 | - | | Fiserv Forum · Milwaukee, WI |
| 17 | Tue Jan 13 | atProvidence | 6:30 PM | 5-4 | .556 | - | | Amica Mutual Pavilion · Providence, RI |
| 18 | Sat Jan 17 | vs#23St John's | 8:00 PM | 4-3 | .571 | - | | Finneran Pavilion · Villanova, PA |
| 19 | Wed Jan 21 | vsGeorgetown | 7:00 PM | 6-2 | .750 | - | | Finneran Pavilion · Villanova, PA |
| 20 | Sat Jan 24 | at#5UConn | 12:30 PM | 7-1 | .875 | - | | Gampel Pavilion · Storrs, CT |
| 21 | Fri Jan 30 | vsProvidence | 7:00 PM | 5-4 | .556 | - | | Finneran Pavilion · Villanova, PA |
| 22 | Wed Feb 4 | vsSeton Hall | 6:30 PM | 8-1 | .889 | - | | Finneran Pavilion · Villanova, PA |
| 23 | Sat Feb 7 | atGeorgetown | 12:00 PM | 6-2 | .750 | - | | Capital One Arena · Washington, D.C. |
| 24 | Tue Feb 10 | vsMarquette | 7:30 PM | 5-4 | .556 | - | | Finneran Pavilion · Villanova, PA |
| 25 | Sat Feb 14 | atCreighton | 2:30 PM | 5-3 | .625 | - | | CHI Health Center Omaha · Omaha, NE |
| 26 | Tue Feb 17 | atXavier | 6:30 PM | 6-3 | .667 | - | | Cintas Center · Cincinnati, OH |
| 27 | Sat Feb 21 | vs#5UConn | 7:00 PM | 7-1 | .875 | - | | Finneran Pavilion · Villanova, PA |
| 28 | Wed Feb 25 | vsButler | 7:00 PM | 7-1 | .875 | - | | Finneran Pavilion · Villanova, PA |
| 29 | Sat Feb 28 | at#23St John's | 8:00 PM | 4-3 | .571 | - | | Carnesecca Arena · Queens, NY |
| 30 | Wed Mar 4 | atDePaul | 8:00 PM | 5-3 | .625 | - | | Wintrust Arena · Chicago, IL |
| 31 | Sat Mar 7 | vsXavier | 12:00 PM | 6-3 | .667 | - | | Finneran Pavilion · Villanova, PA |
