| 1 | Mon Nov 4 | vs Lafayette | W75-63 | 1-0 | 1.000 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 2 | Wed Nov 6 | vs Columbia | L80-90 | 1-1 | .500 | - | CBS | Finneran Pavilion · Villanova, PA |
| 3 | Fri Nov 8 | vs NJIT | W91-54 | 2-1 | .667 | - | FS2 | Finneran Pavilion · Villanova, PA |
| 4 | Tue Nov 12 | at Saint Joseph's | L76-83 | 2-2 | .500 | - | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 5 | Fri Nov 15 | vs Virginia | L60-70 | 2-3 | .400 | - | TNT | Finneran Pavilion · Villanova, PA |
| 6 | Tue Nov 19 | vs Penn | W93-49 | 3-3 | .500 | - | Peacock | Finneran Pavilion · Villanova, PA |
| 7 | Sun Nov 24 | at Maryland | L75-76 | 3-4 | .429 | - | ESPN | XFINITY Center · College Park, MD |
| 8 | Wed Nov 27 | vs Rider | W72-48 | 4-4 | .500 | - | FS2 | Finneran Pavilion · Villanova, PA |
| 9 | Tue Dec 3 | vs #14Cincinnati | W68-60 | 5-4 | .556 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 10 | Sat Dec 7 | at Temple | W94-65 | 6-4 | .600 | - | | Liacouras Center · Philadelphia, PA |
| 11 | Wed Dec 11 | vs Fairleigh | W86-72 | 7-4 | .636 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 12 | Tue Dec 17 | vs Seton Hall | W79-67 | 8-4 | .667 | - | Peacock | Finneran Pavilion · Villanova, PA |
| 13 | Sat Dec 21 | at Creighton | L79-86 | 8-5 | .615 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 14 | Wed Jan 1 | at Butler | W73-65 | 9-5 | .643 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 15 | Sat Jan 4 | vs DePaul | W100-56 | 10-5 | .667 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 16 | Wed Jan 8 | vs #9UConn | W68-66 | 11-5 | .688 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 17 | Sat Jan 11 | at St John's | L68-80 | 11-6 | .647 | - | CBS | Carnesecca Arena · Queens, NY |
| 18 | Tue Jan 14 | at Xavier | L63-69 | 11-7 | .611 | - | FS1 | Cintas Center · Cincinnati, OH |
| 19 | Fri Jan 17 | vs Providence | W75-73 | 12-7 | .632 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 20 | Mon Jan 20 | vs Georgetown | L63-64 | 12-8 | .600 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 21 | Fri Jan 24 | at #10Marquette | L74-87 | 12-9 | .571 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 22 | Sat Feb 1 | vsCreighton | L60-62 | 12-10 | .545 | - | FOX | Finneran Pavilion · Villanova, PA |
| 23 | Wed Feb 5 | atDePaul | W59-49 | 13-10 | .565 | - | CBS | Wintrust Arena · Chicago, IL |
| 24 | Sun Feb 9 | vsXavier | W80-68 | 14-10 | .583 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 25 | Wed Feb 12 | vs#9St John's | W73-71 | 15-10 | .600 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 26 | Sat Feb 15 | atProvidence | L62-75 | 15-11 | .577 | - | CBS | Amica Mutual Pavilion · Providence, RI |
| 27 | Tue Feb 18 | atUConn | L59-66 | 15-12 | .556 | - | FS1 | Gampel Pavilion · Storrs, CT |
| 28 | Fri Feb 21 | vs#16Marquette | W81-66 | 16-12 | .571 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 29 | Wed Feb 26 | atSeton Hall | W59-54 | 17-12 | .586 | - | FS1 | Prudential Center · Newark, NJ |
| 30 | Sat Mar 1 | vsButler | W80-70 | 18-12 | .600 | - | FOX | Finneran Pavilion · Villanova, PA |
| 31 | Tue Mar 4 | atGeorgetown | L73-75 | 18-13 | .581 | - | Peacock | Capital One Arena · Washington, D.C. |
| 32 | Wed Mar 12 | vsSeton Hall | W67-55 | 19-13 | .594 | - | Peacock | Finneran Pavilion · Villanova, PA |
| 33 | Thu Mar 13 | atUConn | L56-73 | 19-14 | .576 | - | FS1 | Gampel Pavilion · Storrs, CT |
