| Sun Nov 24 | at Maryland | 1:00 PM | 4-1 | .800 | XFINITY Center · College Park, MD |
| Wed Nov 27 | vs Rider | 7:00 PM | 3-2 | .600 | Finneran Pavilion · Villanova, PA |
| Tue Dec 3 | vs #18Cincinnati | 6:30 PM | 4-0 | 1.000 | Finneran Pavilion · Villanova, PA |
| Wed Dec 11 | vs Fairleigh | 7:00 PM | 2-4 | .333 | Finneran Pavilion · Villanova, PA |
| Tue Dec 17 | vs Seton Hall | 7:30 PM | 3-2 | .600 | Finneran Pavilion · Villanova, PA |
| Sat Dec 21 | at #14Creighton | 4:00 PM | 4-0 | 1.000 | CHI Health Center Omaha · Omaha, NE |
| Wed Jan 1 | at Butler | 6:30 PM | 3-1 | .750 | Hinkle Fieldhouse · Indianapolis, IN |
| Sat Jan 4 | vs DePaul | 12:00 PM | 5-0 | 1.000 | Finneran Pavilion · Villanova, PA |
| Wed Jan 8 | vs #2UConn | 6:30 PM | 4-0 | 1.000 | Finneran Pavilion · Villanova, PA |
| Sat Jan 11 | at #22St John's | 7:00 PM | 4-1 | .800 | Carnesecca Arena · Queens, NY |
| Tue Jan 14 | at Xavier | 6:30 PM | 5-0 | 1.000 | Cintas Center · Cincinnati, OH |
| Fri Jan 17 | vs Providence | 7:00 PM | 5-0 | 1.000 | Finneran Pavilion · Villanova, PA |
| Mon Jan 20 | vs Georgetown | 6:00 PM | 3-1 | .750 | Finneran Pavilion · Villanova, PA |
| Fri Jan 24 | at #15Marquette | 7:00 PM | 5-0 | 1.000 | Fiserv Forum · Milwaukee, WI |
| Sat Feb 1 | vs#14Creighton | 1:00 PM | 4-0 | 1.000 | Finneran Pavilion · Villanova, PA |
| Wed Feb 5 | atDePaul | 9:00 PM | 5-0 | 1.000 | Wintrust Arena · Chicago, IL |
| Sun Feb 9 | vsXavier | 12:00 PM | 5-0 | 1.000 | Finneran Pavilion · Villanova, PA |
| Wed Feb 12 | vs#22St John's | 6:00 PM | 4-1 | .800 | Finneran Pavilion · Villanova, PA |
| Sat Feb 15 | atProvidence | 12:00 AM | 5-0 | 1.000 | Amica Mutual Pavilion · Providence, RI |
| Tue Feb 18 | at#2UConn | 6:30 PM | 4-0 | 1.000 | Gampel Pavilion · Storrs, CT |
| Fri Feb 21 | vs#15Marquette | 7:00 PM | 5-0 | 1.000 | Finneran Pavilion · Villanova, PA |
| Wed Feb 26 | atSeton Hall | 8:30 PM | 3-2 | .600 | Prudential Center · Newark, NJ |
| Sat Mar 1 | vsButler | 12:00 PM | 3-1 | .750 | Finneran Pavilion · Villanova, PA |
| Tue Mar 4 | atGeorgetown | 8:00 PM | 3-1 | .750 | Capital One Arena · Washington, D.C. |
Penn
Virginia
Saint Joseph's
NJIT
Columbia
Lafayette