| 1 | Mon Nov 7 | vs La Salle | W81-68 | 1-0 | 1.000 | #16 | FS1 | Finneran Pavilion · Villanova, PA |
| 2 | Fri Nov 11 | atTemple | L64-68 | 1-1 | .500 | #16 | ESPNU | Liacouras Center · Philadelphia, PA |
| 3 | Mon Nov 14 | vsDelaware St | W60-50 | 2-1 | .667 | - | FS2 | Finneran Pavilion · Villanova, PA |
| 4 | Fri Nov 18 | atMichigan St | L71-73 | 2-2 | .500 | - | FS1 | Breslin Center · East Lansing, MI |
| 5 | Thu Nov 24 | vsIowa State | L79-81 (OT) | 2-3 | .400 | - | ESPN2 | Moda Center · Portland, OR |
| 6 | Fri Nov 25 | vsPortland | L71-83 | 2-4 | .333 | - | ESPN2 | Finneran Pavilion · Villanova, PA |
| 7 | Sun Nov 27 | atOregon | L67-74 | 2-5 | .286 | - | ESPN2 | Chiles Center · Portland, OR |
| 8 | Sat Dec 3 | vsOklahoma | W70-66 | 3-5 | .375 | - | CBS | Xfinity Mobile Arena · Philadelphia, PA |
| 9 | Wed Dec 7 | vsPenn | W70-59 | 4-5 | .444 | - | CBSSN | Finneran Pavilion · Villanova, PA |
| 10 | Sat Dec 10 | vsBoston College | W77-56 | 5-5 | .500 | - | FOX | Prudential Center · Newark, NJ |
| 11 | Sat Dec 17 | atSaint Joseph's | W71-64 | 6-5 | .545 | - | CBSSN | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 12 | Wed Dec 21 | vsSt John's | W78-63 | 7-5 | .583 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 13 | Wed Dec 28 | at2UConn | L66-74 | 7-6 | .538 | - | FS1 | Gampel Pavilion · Storrs, CT |
| 14 | Sat Dec 31 | vsMarquette | L66-68 | 7-7 | .500 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 15 | Wed Jan 4 | atGeorgetown | W73-57 | 8-7 | .533 | - | FS1 | Capital One Arena · Washington, D.C. |
| 16 | Sat Jan 7 | vs18Xavier | L80-88 | 8-8 | .500 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 17 | Tue Jan 10 | atDePaul | L65-75 | 8-9 | .471 | - | CBSSN | Wintrust Arena · Chicago, IL |
| 18 | Fri Jan 13 | atButler | L71-79 | 8-10 | .444 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 19 | Mon Jan 16 | vsGeorgetown | W77-73 | 9-10 | .474 | - | FOX | Finneran Pavilion · Villanova, PA |
| 20 | Fri Jan 20 | atSt John's | W57-49 | 10-10 | .500 | - | FS1 | Carnesecca Arena · Queens, NY |
| 21 | Sun Jan 29 | vs23Providence | L65-70 | 10-11 | .476 | - | FS1 | Xfinity Mobile Arena · Philadelphia, PA |
| 22 | Wed Feb 1 | at14Marquette | L64-73 | 10-12 | .455 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 23 | Sat Feb 4 | atCreighton | L61-66 | 10-13 | .435 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 24 | Wed Feb 8 | vsDePaul | W81-65 | 11-13 | .458 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 25 | Sat Feb 11 | vsSeton Hall | W58-54 | 12-13 | .480 | - | FS1 | Xfinity Mobile Arena · Philadelphia, PA |
| 26 | Tue Feb 14 | vsButler | W62-50 | 13-13 | .500 | - | CBSSN | Finneran Pavilion · Villanova, PA |
| 27 | Sat Feb 18 | at24Providence | L72-85 | 13-14 | .481 | - | FOX | Amica Mutual Pavilion · Providence, RI |
| 28 | Tue Feb 21 | at16Xavier | W64-63 | 14-14 | .500 | - | FS1 | Cintas Center · Cincinnati, OH |
| 29 | Sat Feb 25 | vs19Creighton | W79-67 | 15-14 | .517 | - | FOX | Xfinity Mobile Arena · Philadelphia, PA |
| 30 | Tue Feb 28 | atSeton Hall | W76-72 | 16-14 | .533 | - | FS1 | Prudential Center · Newark, NJ |
| 31 | Sat Mar 4 | vs14UConn | L59-71 | 16-15 | .516 | - | FOX | Xfinity Mobile Arena · Philadelphia, PA |
| 32 | Wed Mar 8 | vsGeorgetown | W80-48 | 17-15 | .531 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 33 | Thu Mar 9 | atCreighton | L74-87 | 17-16 | .515 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 34 | Tue Mar 14 | atLiberty | L57-62 | 17-17 | .500 | - | ESPN2 | Liberty Arena · Lynchburg, VA |
