| 1 | Mon Nov 4 | vs Lindenwood | W93-60 | 1-0 | 1.000 | - | ESPN+ | Lloyd Noble Center · Norman, OK |
| 2 | Mon Nov 11 | vs N'Western St | W73-57 | 2-0 | 1.000 | - | ESPN+ | Lloyd Noble Center · Norman, OK |
| 3 | Sat Nov 16 | vs Stetson | W85-64 | 3-0 | 1.000 | - | ESPN+ | Lloyd Noble Center · Norman, OK |
| 4 | Thu Nov 21 | vs E Texas A&M | W84-56 | 4-0 | 1.000 | - | ESPN+ | Lloyd Noble Center · Norman, OK |
| 5 | Wed Nov 27 | vs Providence | W79-77 | 5-0 | 1.000 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 6 | Thu Nov 28 | vs #24Arizona | W82-77 | 6-0 | 1.000 | - | ESPN | Lloyd Noble Center · Norman, OK |
| 7 | Fri Nov 29 | at Louisville | W69-64 | 7-0 | 1.000 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 8 | Tue Dec 3 | vs Georgia Tech | W76-61 | 8-0 | 1.000 | #21 | ESPNU | Lloyd Noble Center · Norman, OK |
| 9 | Sat Dec 7 | vs Alcorn St | W94-78 | 9-0 | 1.000 | #21 | ESPN+ | Lloyd Noble Center · Norman, OK |
| 10 | Sat Dec 14 | vs Oklahoma St | W80-65 | 10-0 | 1.000 | #13 | ESPNU | Lloyd Noble Center · Norman, OK |
| 11 | Wed Dec 18 | vs #24Michigan | W87-86 | 11-0 | 1.000 | #14 | ESPN2 | Lloyd Noble Center · Norman, OK |
| 12 | Sun Dec 22 | vs C Arkansas | W89-66 | 12-0 | 1.000 | #14 | ESPN+ | Lloyd Noble Center · Norman, OK |
| 13 | Sun Dec 29 | vs Prairie View | W89-67 | 13-0 | 1.000 | #12 | ESPN+ | Lloyd Noble Center · Norman, OK |
| 14 | Sat Jan 4 | at #5Alabama | L79-107 | 13-1 | .929 | #12 | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 15 | Wed Jan 8 | vs #10Texas A&M | L78-80 | 13-2 | .867 | #17 | SEC Network | Lloyd Noble Center · Norman, OK |
| 16 | Sat Jan 11 | at Georgia | L62-72 | 13-3 | .813 | #17 | ESPN2 | Stegeman Coliseum · Athens, GA |
| 17 | Wed Jan 15 | vs Texas | L73-77 | 13-4 | .765 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 18 | Sat Jan 18 | vs South Carolina | W82-62 | 14-4 | .778 | - | ESPNU | Lloyd Noble Center · Norman, OK |
| 19 | Sat Jan 25 | at Arkansas | W65-62 | 15-4 | .789 | - | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 20 | Tue Jan 28 | at#13Texas A&M | L68-75 | 15-5 | .750 | - | SEC Network | Reed Arena · College Station, TX |
| 21 | Sat Feb 1 | vs #24Vanderbilt | W97-67 | 16-5 | .762 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 22 | Tue Feb 4 | at #1Auburn | L70-98 | 16-6 | .727 | - | SEC Network | Neville Arena · Auburn, AL |
| 23 | Sat Feb 8 | vs #4Tennessee | L52-70 | 16-7 | .696 | - | ESPN | Lloyd Noble Center · Norman, OK |
| 24 | Wed Feb 12 | at #21Missouri | L58-82 | 16-8 | .667 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 25 | Sat Feb 15 | vs LSU | L79-82 | 16-9 | .640 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 26 | Tue Feb 18 | at #2Florida | L63-85 | 16-10 | .615 | - | ESPN2 | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
#21Mississippi St
#17Kentucky
#24Ole Miss