| 1 | Mon Nov 7 | vs Sam Houston | L51-52 | 0-1 | .000 | - | | Lloyd Noble Center · Norman, OK |
| 2 | Fri Nov 11 | vsAR-Pine Bluff | W66-58 | 1-1 | .500 | - | | Lloyd Noble Center · Norman, OK |
| 3 | Tue Nov 15 | vsUNC Wilmington | W74-53 | 2-1 | .667 | - | | Lloyd Noble Center · Norman, OK |
| 4 | Fri Nov 18 | vsSouth Alabama | W64-60 | 3-1 | .750 | - | | Lloyd Noble Center · Norman, OK |
| 5 | Thu Nov 24 | atNebraska | W69-56 | 4-1 | .800 | - | ESPN | Pinnacle Bank Arena · Lincoln, NE |
| 6 | Fri Nov 25 | atSeton Hall | W77-64 | 5-1 | .833 | - | ESPN2 | Prudential Center · Newark, NJ |
| 7 | Sun Nov 27 | vsOle Miss | W59-55 | 6-1 | .857 | - | ESPN | Lloyd Noble Center · Norman, OK |
| 8 | Sat Dec 3 | atVillanova | L66-70 | 6-2 | .750 | - | CBS | Finneran Pavilion · Villanova, PA |
| 9 | Tue Dec 6 | vsKansas City | W75-53 | 7-2 | .778 | - | | Lloyd Noble Center · Norman, OK |
| 10 | Sat Dec 10 | at#9Arkansas | L78-88 | 7-3 | .700 | - | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 11 | Sat Dec 17 | vsC Arkansas | W87-66 | 8-3 | .727 | - | | Lloyd Noble Center · Norman, OK |
| 12 | Tue Dec 20 | vsFlorida | W62-53 | 9-3 | .750 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 13 | Sat Dec 31 | vs#6Texas | L69-70 | 9-4 | .692 | - | | Lloyd Noble Center · Norman, OK |
| 14 | Wed Jan 4 | vs#25Iowa State | L60-63 | 9-5 | .643 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 15 | Sat Jan 7 | atTexas Tech | W68-63 (OT) | 10-5 | .667 | - | | United Supermarkets Arena · Lubbock, TX |
| 16 | Tue Jan 10 | at#2Kansas | L75-79 | 10-6 | .625 | - | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 17 | Sat Jan 14 | vsWest Virginia | W77-76 | 11-6 | .647 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 18 | Wed Jan 18 | atOklahoma St | L56-72 | 11-7 | .611 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 19 | Sat Jan 21 | vs#21Baylor | L60-62 | 11-8 | .579 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 20 | Tue Jan 24 | at#11TCU | L52-79 | 11-9 | .550 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 21 | Sat Jan 28 | vsAlabama | W93-69 | 12-9 | .571 | - | ESPN | Lloyd Noble Center · Norman, OK |
| 22 | Wed Feb 1 | vsOklahoma St | L61-71 | 12-10 | .545 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 23 | Sat Feb 4 | atWest Virginia | L61-93 | 12-11 | .522 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 24 | Wed Feb 8 | at#14Baylor | L72-82 | 12-12 | .500 | - | ESPNU | Ferrell Center · Waco, TX |
| 25 | Sat Feb 11 | vs#9Kansas | L55-78 | 12-13 | .480 | - | CBS | Lloyd Noble Center · Norman, OK |
| 26 | Tue Feb 14 | vs#12Kansas St | W79-65 | 13-13 | .500 | - | ESPNU | Lloyd Noble Center · Norman, OK |
| 27 | Sat Feb 18 | at#6Texas | L83-85 (OT) | 13-14 | .481 | - | | Moody Center · Austin, TX |
| 28 | Tue Feb 21 | vsTexas Tech | L63-74 | 13-15 | .464 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 29 | Sat Feb 25 | at#23Iowa State | W61-50 | 14-15 | .483 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 30 | Wed Mar 1 | at#11Kansas St | L69-85 | 14-16 | .467 | - | | Bramlage Coliseum · Manhattan, KS |
| 31 | Sat Mar 4 | vs#22TCU | W74-60 | 15-16 | .484 | - | | Lloyd Noble Center · Norman, OK |
| 32 | Wed Mar 8 | atOklahoma St | L49-57 | 15-17 | .469 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
