| 2 | Thu Dec 3 | vs UTSA | W105-66 | 1-0 | 1.000 | - | | Lloyd Noble Center · Norman, OK |
| 3 | Sun Dec 6 | at TCU | W82-78 | 2-0 | 1.000 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 4 | Wed Dec 9 | at Xavier | L77-99 | 2-1 | .667 | - | FS1 | Cintas Center · Cincinnati, OH |
| 5 | Sat Dec 12 | vs FAMU | W85-54 | 3-1 | .750 | - | | Lloyd Noble Center · Norman, OK |
| 6 | Wed Dec 16 | vs Oral Roberts | W79-65 | 4-1 | .800 | - | | Lloyd Noble Center · Norman, OK |
| 7 | Sat Dec 19 | vs Hou Christian | W84-65 | 5-1 | .833 | - | | Lloyd Noble Center · Norman, OK |
| 8 | Tue Dec 22 | vs #15Texas Tech | L67-69 | 5-2 | .714 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 9 | Sat Jan 2 | vs #9West Virginia | W75-71 | 6-2 | .750 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 10 | Wed Jan 6 | at #2Baylor | L61-76 | 6-3 | .667 | - | ESPN2 | Ferrell Center · Waco, TX |
| 11 | Sat Jan 9 | at #6Kansas | L59-63 | 6-4 | .600 | - | CBS | Allen Fieldhouse · Lawrence, KS |
| 12 | Tue Jan 12 | vs TCU | W82-46 | 7-4 | .636 | - | | Lloyd Noble Center · Norman, OK |
| 13 | Sat Jan 16 | at Oklahoma St | PPD | 16-11 | .593 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 14 | Tue Jan 19 | vs Kansas St | W76-50 | 8-4 | .667 | - | | Lloyd Noble Center · Norman, OK |
| 15 | Sat Jan 23 | vs #9Kansas | W75-68 | 9-4 | .692 | - | ESPN | Lloyd Noble Center · Norman, OK |
| 16 | Tue Jan 26 | at #5Texas | W80-79 | 10-4 | .714 | #24 | ESPN2 | Moody Center · Austin, TX |
| 17 | Sat Jan 30 | vs Alabama | W66-61 | 11-4 | .733 | - | ESPN | Lloyd Noble Center · Norman, OK |
| 18 | Mon Feb 1 | at #13Texas Tech | L52-57 | 11-5 | .688 | #9 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 19 | Sat Feb 6 | vs Iowa State | W79-72 | 12-5 | .706 | #9 | ESPN2 | Lloyd Noble Center · Norman, OK |
| 21 | Sat Feb 13 | at #14West Virginia | W91-90 (2OT) | 13-5 | .722 | #12 | | WVU Coliseum · Morgantown, WV |
| 22 | Thu Feb 18 | vs #12Texas | PPD | 16-11 | .593 | #9 | | Lloyd Noble Center · Norman, OK |
| 23 | Sat Feb 20 | at Iowa State | W66-56 | 14-5 | .737 | #9 | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 24 | Tue Feb 23 | at Kansas St | L57-62 | 14-6 | .700 | #7 | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 25 | Sat Feb 27 | vs Oklahoma St | L90-94 (OT) | 14-7 | .667 | #7 | ABC | Lloyd Noble Center · Norman, OK |
| 26 | Mon Mar 1 | at #17Oklahoma St | L75-79 | 14-8 | .636 | #16 | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 27 | Thu Mar 4 | vs #15Texas | L65-69 | 14-9 | .609 | #16 | ESPN | Lloyd Noble Center · Norman, OK |
| 28 | Wed Mar 10 | vs Iowa State | W79-73 | 15-9 | .625 | - | ESPN | Lloyd Noble Center · Norman, OK |
| 29 | Thu Mar 11 | at Kansas | L62-69 | 15-10 | .600 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 30 | Sat Mar 20 | vs #9Missouri | W72-68 | 16-10 | .615 | #8 | TNT | Lucas Oil Stadium · Indianapolis, IN |
| 31 | Mon Mar 22 | at #1Gonzaga | L71-87 | 16-11 | .593 | #8 | CBS | Hinkle Fieldhouse · Indianapolis, IN |