| 1 | Mon Nov 3 | vs St Francis PA | 8:30 PM | 16-18 | .471 | - | | Lloyd Noble Center · Norman, OK |
| 2 | Sat Nov 8 | at#21Gonzaga | 10:30 PM | 26-9 | .743 | - | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 3 | Tue Nov 11 | vsAR-Pine Bluff | 8:00 PM | 6-25 | .194 | - | | Lloyd Noble Center · Norman, OK |
| 4 | Sat Nov 15 | atNebraska | 7:00 PM | 21-14 | .600 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 5 | Thu Nov 20 | vsOral Roberts | 8:00 PM | 7-23 | .233 | - | | Lloyd Noble Center · Norman, OK |
| 6 | Sun Nov 23 | vsAlcorn St | 2:00 PM | 11-21 | .344 | - | | Lloyd Noble Center · Norman, OK |
| 7 | Fri Nov 28 | atMarquette | TBD | 23-11 | .676 | - | | Fiserv Forum · Milwaukee, WI |
| 8 | Tue Dec 2 | atWake Forest | 7:00 PM | 21-11 | .656 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 9 | Sat Dec 6 | atArizona St | 10:00 PM | 13-20 | .394 | - | CBS | Desert Financial Arena · Tempe, AZ |
| 10 | Sat Dec 13 | vsOklahoma St | 1:00 PM | 17-18 | .486 | - | FOX | Lloyd Noble Center · Norman, OK |
| 11 | Tue Dec 16 | vsKansas City | 7:00 PM | 13-20 | .394 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 12 | Mon Dec 22 | vsStetson | 9:00 PM | 8-24 | .250 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 13 | Mon Dec 29 | vsMiss Valley St | 8:00 PM | 3-28 | .097 | - | | Lloyd Noble Center · Norman, OK |
| 14 | Sat Jan 3 | vsOle Miss | 3:30 PM | 24-12 | .667 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 15 | Wed Jan 7 | atMississippi St | 7:00 PM | 21-13 | .618 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 16 | Sat Jan 10 | atTexas A&M | 3:30 PM | 23-11 | .676 | - | SEC Network | Reed Arena · College Station, TX |
| 17 | Tue Jan 13 | vs#3Florida | TBD | 36-4 | .900 | - | | Lloyd Noble Center · Norman, OK |
| 18 | Sat Jan 17 | vs#15Alabama | 1:00 PM | 28-9 | .757 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 19 | Tue Jan 20 | atSouth Carolina | 7:00 PM | 12-20 | .375 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 20 | Sat Jan 24 | atMissouri | TBD | 22-12 | .647 | - | | Mizzou Arena · Columbia, MO |
| 21 | Tue Jan 27 | vs#14Arkansas | TBD | 22-14 | .611 | - | | Lloyd Noble Center · Norman, OK |
| 22 | Sat Jan 31 | vsTexas | TBD | 19-16 | .543 | - | | Lloyd Noble Center · Norman, OK |
| 23 | Wed Feb 4 | at#9Kentucky | 7:00 PM | 24-12 | .667 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 24 | Sat Feb 7 | atVanderbilt | 3:30 PM | 20-13 | .606 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 25 | Sat Feb 14 | vsGeorgia | 3:30 PM | 20-13 | .606 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 26 | Tue Feb 17 | at#18Tennessee | TBD | 30-8 | .789 | - | | Thompson-Boling Arena · Knoxville, TN |
| 27 | Sat Feb 21 | vsTexas A&M | 8:30 PM | 23-11 | .676 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 28 | Tue Feb 24 | vs#20Auburn | TBD | 32-6 | .842 | - | | Lloyd Noble Center · Norman, OK |
| 29 | Sat Feb 28 | atLSU | 6:00 PM | 14-18 | .438 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 30 | Tue Mar 3 | vsMissouri | 7:00 PM | 22-12 | .647 | - | ESPNU | Lloyd Noble Center · Norman, OK |
| 31 | Sat Mar 7 | atTexas | 8:30 PM | 19-16 | .543 | - | SEC Network | Moody Center · Austin, TX |
