| 1 | Tue Nov 5 | vs UTSA | W85-67 | 1-0 | 1.000 | - | | Lloyd Noble Center · Norman, OK |
| 2 | Sat Nov 9 | atMinnesota | W71-62 | 2-0 | 1.000 | - | BTN | Williams Arena · Minneapolis, MN |
| 3 | Tue Nov 12 | atOregon St | W77-69 | 3-0 | 1.000 | - | ESPN2 | Gill Coliseum · Corvallis, OR |
| 4 | Mon Nov 18 | vsWilliam & Mary | W75-70 | 4-0 | 1.000 | - | | Lloyd Noble Center · Norman, OK |
| 5 | Thu Nov 21 | vsMD-Eastern | W91-64 | 5-0 | 1.000 | - | | Lloyd Noble Center · Norman, OK |
| 6 | Mon Nov 25 | vsStanford | L54-73 | 5-1 | .833 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 7 | Tue Nov 26 | atMissouri | W77-66 | 6-1 | .857 | - | ESPNEWS | Mizzou Arena · Columbia, MO |
| 8 | Thu Dec 5 | atNorth Texas | W82-80 | 7-1 | .875 | - | | The Super Pit · Denton, TX |
| 9 | Sat Dec 14 | atWichita St | L75-80 | 7-2 | .778 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 10 | Tue Dec 17 | atCreighton | L73-83 | 7-3 | .700 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 11 | Sat Dec 21 | vsUCF | W53-52 | 8-3 | .727 | - | | Lloyd Noble Center · Norman, OK |
| 12 | Mon Dec 30 | vsUT Rio Grande | W91-72 | 9-3 | .750 | - | | Lloyd Noble Center · Norman, OK |
| 13 | Sat Jan 4 | vsKansas St | W66-61 | 10-3 | .769 | - | | Lloyd Noble Center · Norman, OK |
| 14 | Wed Jan 8 | atTexas | W72-62 | 11-3 | .786 | - | ESPN2 | Moody Center · Austin, TX |
| 15 | Sat Jan 11 | atIowa State | L68-81 | 11-4 | .733 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 16 | Tue Jan 14 | vs#6Kansas | L52-66 | 11-5 | .688 | - | ESPN | Lloyd Noble Center · Norman, OK |
| 17 | Sat Jan 18 | vsTCU | W83-63 | 12-5 | .706 | - | | Lloyd Noble Center · Norman, OK |
| 18 | Mon Jan 20 | at#1Baylor | L57-61 | 12-6 | .667 | - | ESPN | Ferrell Center · Waco, TX |
| 19 | Sat Jan 25 | vsMississippi St | W63-62 | 13-6 | .684 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 20 | Wed Jan 29 | atKansas St | L53-61 | 13-7 | .650 | - | | Bramlage Coliseum · Manhattan, KS |
| 21 | Sat Feb 1 | vsOklahoma St | W82-69 | 14-7 | .667 | - | ABC | Lloyd Noble Center · Norman, OK |
| 22 | Tue Feb 4 | atTexas Tech | L61-69 | 14-8 | .636 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 23 | Sat Feb 8 | vs#13West Virginia | W69-59 | 15-8 | .652 | - | ESPNU | Lloyd Noble Center · Norman, OK |
| 24 | Wed Feb 12 | vsIowa State | W90-61 | 16-8 | .667 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 25 | Sat Feb 15 | at#3Kansas | L70-87 | 16-9 | .640 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 26 | Tue Feb 18 | vs#1Baylor | L54-65 | 16-10 | .615 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 27 | Sat Feb 22 | atOklahoma St | L66-83 | 16-11 | .593 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 28 | Tue Feb 25 | vs#22Texas Tech | W65-51 | 17-11 | .607 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 29 | Sat Feb 29 | at#20West Virginia | W73-62 | 18-11 | .621 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 30 | Tue Mar 3 | vsTexas | L51-52 | 18-12 | .600 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 31 | Sat Mar 7 | atTCU | W78-76 | 19-12 | .613 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
