| 1 | Wed Nov 6 | vs UT Rio Grande | W99-86 | 1-0 | 1.000 | #15 | FS2 | CHI Health Center Omaha · Omaha, NE |
| 2 | Sun Nov 10 | vs Fairleigh | W96-70 | 2-0 | 1.000 | #15 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 3 | Wed Nov 13 | vs Hou Christian | W78-43 | 3-0 | 1.000 | #14 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 4 | Sat Nov 16 | vs Kansas City | W79-56 | 4-0 | 1.000 | #14 | FS2 | CHI Health Center Omaha · Omaha, NE |
| 5 | Fri Nov 22 | vs Nebraska | L63-74 | 4-1 | .800 | #14 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 6 | Tue Nov 26 | at SDSU | L53-71 | 4-2 | .667 | #21 | TBS | Viejas Arena · San Diego, CA |
| 7 | Wed Nov 27 | at #20Texas A&M | L73-77 | 4-3 | .571 | #21 | Max | Reed Arena · College Station, TX |
| 8 | Sat Nov 30 | at Notre Dame | W80-76 | 5-3 | .625 | #21 | truTV | Purcell Pavilion · South Bend, IN |
| 9 | Wed Dec 4 | vs #1Kansas | W76-63 | 6-3 | .667 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 10 | Sat Dec 7 | vs UNLV | W83-65 | 7-3 | .700 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 11 | Sat Dec 14 | at #7Alabama | L75-83 | 7-4 | .636 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 12 | Wed Dec 18 | at Georgetown | L57-81 | 7-5 | .583 | - | CBS | Capital One Arena · Washington, D.C. |
| 13 | Sat Dec 21 | vs Villanova | W86-79 | 8-5 | .615 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 14 | Tue Dec 31 | vs St John's | W57-56 | 9-5 | .643 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
| 15 | Fri Jan 3 | at #8Marquette | L71-79 | 9-6 | .600 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 16 | Sat Jan 11 | at Butler | W80-76 | 10-6 | .625 | - | FOX | Hinkle Fieldhouse · Indianapolis, IN |
| 17 | Tue Jan 14 | vs Providence | W84-64 | 11-6 | .647 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 18 | Sat Jan 18 | at #14UConn | W68-63 | 12-6 | .667 | - | FOX | Gampel Pavilion · Storrs, CT |
| 19 | Tue Jan 21 | at DePaul | W73-49 | 13-6 | .684 | - | FS1 | Wintrust Arena · Chicago, IL |
| 20 | Sat Jan 25 | vs Seton Hall | W79-54 | 14-6 | .700 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 21 | Wed Jan 29 | vs Xavier | W86-77 | 15-6 | .714 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 22 | Sat Feb 1 | atVillanova | W62-60 | 16-6 | .727 | - | FOX | Finneran Pavilion · Villanova, PA |
| 23 | Wed Feb 5 | atProvidence | W80-69 | 17-6 | .739 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 24 | Sat Feb 8 | vs#11Marquette | W77-67 | 18-6 | .750 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 25 | Tue Feb 11 | vsUConn | L66-70 | 18-7 | .720 | #24 | CBS | CHI Health Center Omaha · Omaha, NE |
| 26 | Sun Feb 16 | at#9St John's | L73-79 | 18-8 | .692 | #24 | FS1 | Carnesecca Arena · Queens, NY |
