| 1 | Wed Nov 5 | vs South Dakota | W92-76 | 1-0 | 1.000 | #23 | Peacock | CHI Health Center Omaha · Omaha, NE |
| 2 | Tue Nov 11 | at19Gonzaga | L63-90 | 1-1 | .500 | #23 | ESPN | McCarthey Athletic Center · Spokane, WA |
| 3 | Fri Nov 14 | vsMD-Eastern | W84-45 | 2-1 | .667 | #23 | Peacock | CHI Health Center Omaha · Omaha, NE |
| 4 | Wed Nov 19 | vsNorth Dakota | W75-60 | 3-1 | .750 | - | ESPN+ | CHI Health Center Omaha · Omaha, NE |
| 5 | Mon Nov 24 | atBaylor | L74-81 | 3-2 | .600 | - | truTV | Ferrell Center · Waco, TX |
| 6 | Tue Nov 25 | at15Iowa State | L60-78 | 3-3 | .500 | - | truTV | James H. Hilton Coliseum · Ames, IA |
| 7 | Thu Nov 27 | vsOregon | W76-66 | 4-3 | .571 | - | truTV | CHI Health Center Omaha · Omaha, NE |
| 8 | Tue Dec 2 | vsNicholls | W96-76 | 5-3 | .625 | - | truTV | CHI Health Center Omaha · Omaha, NE |
| 9 | Sun Dec 7 | atNebraska | L50-71 | 5-4 | .556 | - | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 10 | Sat Dec 13 | vsKansas St | L76-83 | 5-5 | .500 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 11 | Wed Dec 17 | atXavier | W98-57 | 6-5 | .545 | - | FS1 | Cintas Center · Cincinnati, OH |
| 12 | Sat Dec 20 | vsMarquette | W84-63 | 7-5 | .583 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
| 13 | Mon Dec 22 | vsUtah Tech | W92-69 | 8-5 | .615 | - | ESPN+ | CHI Health Center Omaha · Omaha, NE |
| 14 | Tue Dec 30 | vsButler | W89-85 | 9-5 | .643 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 15 | Sun Jan 4 | atSeton Hall | L54-56 | 9-6 | .600 | - | Peacock | Prudential Center · Newark, NJ |
| 16 | Wed Jan 7 | atVillanova | W76-72 | 10-6 | .625 | - | Peacock | Finneran Pavilion · Villanova, PA |
| 17 | Sat Jan 10 | vsSt John's | L73-90 | 10-7 | .588 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 18 | Tue Jan 13 | vsGeorgetown | W86-83 (OT) | 11-7 | .611 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
| 19 | Fri Jan 16 | atProvidence | L88-93 | 11-8 | .579 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 20 | Wed Jan 21 | vsXavier | W94-93 | 12-8 | .600 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 21 | Tue Jan 27 | atMarquette | L62-86 | 12-9 | .571 | - | TNT | Fiserv Forum · Milwaukee, WI |
| 22 | Sat Jan 31 | vs2UConn | L58-85 | 12-10 | .545 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 23 | Wed Feb 4 | atGeorgetown | L68-76 | 12-11 | .522 | - | Peacock | Capital One Arena · Washington, D.C. |
| 24 | Sat Feb 7 | vsSeton Hall | W69-68 | 13-11 | .542 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
| 25 | Wed Feb 11 | atDePaul | L71-72 | 13-12 | .520 | - | Peacock | Wintrust Arena · Chicago, IL |
| 26 | Sat Feb 14 | vsVillanova | L69-80 | 13-13 | .500 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 27 | Wed Feb 18 | at5UConn | W91-84 | 14-13 | .519 | - | TNT | Gampel Pavilion · Storrs, CT |
| 28 | Sat Feb 21 | at17St John's | L52-81 | 14-14 | .500 | - | FOX | Carnesecca Arena · Queens, NY |
| 29 | Wed Feb 25 | vsDePaul | L71-72 | 14-15 | .483 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
| 30 | Sat Feb 28 | vsProvidence | L76-79 | 14-16 | .467 | - | TNT | CHI Health Center Omaha · Omaha, NE |
