| 1 | Mon Nov 7 | vs St Thomas (MN) | W72-60 | 1-0 | 1.000 | #9 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 2 | Thu Nov 10 | vs North Dakota | W96-61 | 2-0 | 1.000 | #9 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 3 | Mon Nov 14 | vs Holy Cross | W94-65 | 3-0 | 1.000 | #10 | CBS | CHI Health Center Omaha · Omaha, NE |
| 4 | Thu Nov 17 | vs UC Riverside | W80-51 | 4-0 | 1.000 | #10 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 5 | Mon Nov 21 | vs Texas Tech | W76-65 | 5-0 | 1.000 | - | ESPN2 | CHI Health Center Omaha · Omaha, NE |
| 6 | Tue Nov 22 | at Arkansas | W90-87 | 6-0 | 1.000 | - | ESPN | Bud Walton Arena · Fayetteville, AR |
| 7 | Wed Nov 23 | at Arizona | L79-81 | 6-1 | .857 | - | ESPN | McKale Center · Tucson, AZ |
| 8 | Thu Dec 1 | at Texas | L67-72 | 6-2 | .750 | - | ESPN | Moody Center · Austin, TX |
| 9 | Sun Dec 4 | vs Nebraska | L53-63 | 6-3 | .667 | #7 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 10 | Sat Dec 10 | at BYU | L80-83 | 6-4 | .600 | #21 | FS1 | Marriott Center · Provo, UT |
| 11 | Mon Dec 12 | vs Arizona St | L71-73 | 6-5 | .545 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 12 | Fri Dec 16 | at Marquette | L58-69 | 6-6 | .500 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 13 | Thu Dec 22 | vs Butler | W78-56 | 7-6 | .538 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 14 | Sun Dec 25 | vs DePaul | W80-65 | 8-6 | .571 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 15 | Tue Jan 3 | vs Seton Hall | W83-61 | 9-6 | .600 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 16 | Sat Jan 7 | at #4UConn | L60-69 | 9-7 | .563 | - | FOX | Gampel Pavilion · Storrs, CT |
| 17 | Wed Jan 11 | at #12Xavier | L87-90 | 9-8 | .529 | - | FS1 | Cintas Center · Cincinnati, OH |
| 18 | Sat Jan 14 | vs #19Providence | W73-67 | 10-8 | .556 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 19 | Tue Jan 17 | atButler | W73-52 | 11-8 | .579 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 20 | Wed Jan 25 | vs St John's | W104-76 | 12-8 | .600 | - | CBS | CHI Health Center Omaha · Omaha, NE |
| 21 | Sat Jan 28 | vs#13Xavier | W84-67 | 13-8 | .619 | - | CBS | CHI Health Center Omaha · Omaha, NE |
| 22 | Wed Feb 1 | at Georgetown | W63-53 | 14-8 | .636 | - | CBS | Capital One Arena · Washington, D.C. |
| 23 | Sat Feb 4 | vs Villanova | W66-61 | 15-8 | .652 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 24 | Wed Feb 8 | atSeton Hall | W75-62 | 16-8 | .667 | #23 | FS1 | Prudential Center · Newark, NJ |
| 25 | Sat Feb 11 | vs#21UConn | W56-53 | 17-8 | .680 | #23 | FOX | CHI Health Center Omaha · Omaha, NE |
| 26 | Tue Feb 14 | at#24Providence | L86-94 (2OT) | 17-9 | .654 | #18 | FS1 | Amica Mutual Pavilion · Providence, RI |
| 27 | Sat Feb 18 | atSt John's | W77-67 | 18-9 | .667 | #18 | FS1 | Carnesecca Arena · Queens, NY |
| 28 | Tue Feb 21 | vs#10Marquette | L71-73 | 18-10 | .643 | #19 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 29 | Sat Feb 25 | atVillanova | L67-79 | 18-11 | .621 | #19 | FOX | Finneran Pavilion · Villanova, PA |
| 30 | Wed Mar 1 | vsGeorgetown | W99-59 | 19-11 | .633 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 31 | Sat Mar 4 | atDePaul | W84-70 | 20-11 | .645 | - | FS1 | Wintrust Arena · Chicago, IL |
| 32 | Thu Mar 9 | vsVillanova | W87-74 | 21-11 | .656 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 33 | Fri Mar 10 | atXavier | L60-82 | 21-12 | .636 | - | FS1 | Cintas Center · Cincinnati, OH |
| 34 | Fri Mar 17 | vs #11NC State | W72-63 | 22-12 | .647 | #6 | TNT | CHI Health Center Omaha · Omaha, NE |
| 35 | Sun Mar 19 | at #3Baylor | W85-76 | 23-12 | .657 | #6 | TBS | Ferrell Center · Waco, TX |
| 36 | Fri Mar 24 | vs #15Princeton | W86-75 | 24-12 | .667 | #6 | TBS | CHI Health Center Omaha · Omaha, NE |
| 37 | Sun Mar 26 | at #5SDSU | L56-57 | 24-13 | .649 | #6 | CBS | Viejas Arena · San Diego, CA |
