| 1 | Mon Nov 4 | vs SC Upstate | W97-66 | 1-0 | 1.000 | - | ESPN+ | PNC Arena · Raleigh, NC |
| 2 | Fri Nov 8 | vs Presbyterian | W81-72 | 2-0 | 1.000 | - | ESPN+ | PNC Arena · Raleigh, NC |
| 3 | Wed Nov 13 | vs Coast Car | W82-70 | 3-0 | 1.000 | - | ESPN+ | PNC Arena · Raleigh, NC |
| 4 | Mon Nov 18 | vs Colgate | W72-49 | 4-0 | 1.000 | - | ACC Network | PNC Arena · Raleigh, NC |
| 5 | Fri Nov 22 | vs William & Mary | W84-61 | 5-0 | 1.000 | - | ESPN+ | PNC Arena · Raleigh, NC |
| 6 | Thu Nov 28 | at #13Purdue | L61-71 | 5-1 | .833 | - | FS1 | Mackey Arena · West Lafayette, IN |
| 7 | Fri Nov 29 | at BYU | L61-72 | 5-2 | .714 | - | | Marriott Center · Provo, UT |
| 8 | Wed Dec 4 | vs Texas | L59-63 | 5-3 | .625 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 9 | Sat Dec 7 | vs Florida St | W84-74 (OT) | 6-3 | .667 | - | ESPNU | PNC Arena · Raleigh, NC |
| 10 | Tue Dec 10 | vs Coppin St | W66-56 | 7-3 | .700 | - | ESPN+ | PNC Arena · Raleigh, NC |
| 11 | Sat Dec 14 | at #10Kansas | L60-75 | 7-4 | .636 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 12 | Sun Dec 22 | vs Rider | W89-63 | 8-4 | .667 | - | ACC Network | PNC Arena · Raleigh, NC |
| 13 | Tue Dec 31 | at Virginia | L67-70 | 8-5 | .615 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 14 | Sat Jan 4 | at Wake Forest | L59-77 | 8-6 | .571 | - | The CW Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 15 | Wed Jan 8 | vs Notre Dame | W66-65 | 9-6 | .600 | - | ESPNU | PNC Arena · Raleigh, NC |
| 16 | Sat Jan 11 | vs UNC | L61-63 | 9-7 | .563 | - | ACC Network | PNC Arena · Raleigh, NC |
| 17 | Wed Jan 15 | at Virginia Tech | L76-79 | 9-8 | .529 | - | ESPNU | Cassell Coliseum · Blacksburg, VA |
| 18 | Sat Jan 18 | vs California | L62-65 | 9-9 | .500 | - | ACC Network | PNC Arena · Raleigh, NC |
| 19 | Sat Jan 25 | vs SMU | L57-63 | 9-10 | .474 | - | The CW Network | PNC Arena · Raleigh, NC |
| 20 | Mon Jan 27 | at #2Duke | L64-74 | 9-11 | .450 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 21 | Sat Feb 1 | vs Clemson | L58-68 | 9-12 | .429 | - | The CW Network | PNC Arena · Raleigh, NC |
| 22 | Wed Feb 5 | atCalifornia | L62-74 | 9-13 | .409 | - | ACC Network | Haas Pavilion · Berkeley, CA |
| 23 | Sat Feb 8 | at Stanford | L73-74 | 9-14 | .391 | - | ACC Network | Maples Pavilion · Stanford, CA |
| 24 | Wed Feb 12 | vs Louisville | L66-91 | 9-15 | .375 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 25 | Sat Feb 15 | vs Boston College | W70-62 | 10-15 | .400 | - | ACC Network | PNC Arena · Raleigh, NC |
| 26 | Wed Feb 19 | atUNC | L73-97 | 10-16 | .385 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
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