| 1 | Tue Nov 9 | vs Bucknell | W88-70 | 1-0 | 1.000 | - | | PNC Arena · Raleigh, NC |
| 2 | Sat Nov 13 | vs Colgate | W77-74 | 2-0 | 1.000 | - | | PNC Arena · Raleigh, NC |
| 3 | Tue Nov 16 | at C Connecticut | W79-65 | 3-0 | 1.000 | - | | William H. Detrick Gymnasium · New Britain, CT |
| 4 | Wed Nov 17 | vs Oklahoma St | L68-74 | 3-1 | .750 | - | CBS | PNC Arena · Raleigh, NC |
| 5 | Sun Nov 21 | vs Texas So | W65-57 | 4-1 | .800 | - | | PNC Arena · Raleigh, NC |
| 6 | Sat Nov 27 | vs Louisiana Tech | W90-81 | 5-1 | .833 | - | | PNC Arena · Raleigh, NC |
| 7 | Wed Dec 1 | vs Nebraska | W104-100 (4OT) | 6-1 | .857 | - | ESPNU | PNC Arena · Raleigh, NC |
| 8 | Sat Dec 4 | vs Louisville | L68-73 | 6-2 | .750 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 9 | Thu Dec 9 | vs Bethune | W65-48 | 7-2 | .778 | - | | PNC Arena · Raleigh, NC |
| 10 | Sun Dec 12 | vs Purdue | L72-82 (OT) | 7-3 | .700 | - | BTN | PNC Arena · Raleigh, NC |
| 11 | Fri Dec 17 | vs Richmond | L74-83 | 7-4 | .636 | - | ACC Network | PNC Arena · Raleigh, NC |
| 12 | Tue Dec 21 | vs Wright St | L70-84 | 7-5 | .583 | - | | PNC Arena · Raleigh, NC |
| 13 | Wed Dec 29 | at Miami | L83-91 | 7-6 | .538 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 14 | Sat Jan 1 | vs Florida St | L81-83 | 7-7 | .500 | - | ACC Network | PNC Arena · Raleigh, NC |
| 15 | Tue Jan 4 | at Virginia Tech | W68-63 | 8-7 | .533 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 16 | Sat Jan 8 | vs Clemson | L65-70 | 8-8 | .500 | - | | PNC Arena · Raleigh, NC |
| 17 | Wed Jan 12 | atLouisville | W79-63 | 9-8 | .529 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 18 | Sat Jan 15 | at #8Duke | L73-88 | 9-9 | .500 | - | ABC | Cameron Indoor Stadium · Durham, NC |
| 19 | Wed Jan 19 | vsVirginia Tech | L59-62 | 9-10 | .474 | - | ACC Network | PNC Arena · Raleigh, NC |
| 20 | Sat Jan 22 | vs Virginia | W77-63 | 10-10 | .500 | - | ACC Network | PNC Arena · Raleigh, NC |
| 21 | Wed Jan 26 | at Notre Dame | L65-73 | 10-11 | .476 | - | | Purcell Pavilion · South Bend, IN |
| 22 | Sat Jan 29 | at UNC | L80-100 | 10-12 | .455 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 23 | Wed Feb 2 | vs Syracuse | L82-89 | 10-13 | .435 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 24 | Sat Feb 5 | vsNotre Dame | L57-69 | 10-14 | .417 | - | ACC Network | PNC Arena · Raleigh, NC |
| 25 | Wed Feb 9 | vs Wake Forest | L51-69 | 10-15 | .400 | - | ACC Network | PNC Arena · Raleigh, NC |
| 26 | Sat Feb 12 | at Pitt | L69-71 | 10-16 | .385 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 27 | Tue Feb 15 | at Georgia Tech | W76-61 | 11-16 | .407 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 28 | Wed Feb 23 | vs Boston College | L61-69 | 11-17 | .393 | - | | PNC Arena · Raleigh, NC |
| 29 | Sat Feb 26 | vsUNC | L74-84 | 11-18 | .379 | - | ESPN | PNC Arena · Raleigh, NC |
| 30 | Wed Mar 2 | atWake Forest | L76-101 | 11-19 | .367 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 31 | Sat Mar 5 | atFlorida St | L76-89 | 11-20 | .355 | - | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 32 | Tue Mar 8 | atClemson | L64-70 | 11-21 | .344 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
