| 1 | Mon Nov 6 | vs The Citadel | W72-59 | 1-0 | 1.000 | - | | PNC Arena · Raleigh, NC |
| 2 | Fri Nov 10 | vs Abilene Chrstn | W84-64 | 2-0 | 1.000 | - | | PNC Arena · Raleigh, NC |
| 3 | Fri Nov 17 | vs Charleston So | W87-53 | 3-0 | 1.000 | - | | PNC Arena · Raleigh, NC |
| 4 | Thu Nov 23 | at Vanderbilt | W84-78 | 4-0 | 1.000 | - | ESPN2 | Memorial Gymnasium (TN) · Nashville, TN |
| 5 | Fri Nov 24 | at BYU | L86-95 | 4-1 | .800 | - | ESPN2 | Marriott Center · Provo, UT |
| 6 | Tue Nov 28 | at Ole Miss | L52-72 | 4-2 | .667 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 7 | Sat Dec 2 | at Boston College | W84-78 (OT) | 5-2 | .714 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 8 | Wed Dec 6 | vs MD-Eastern | W93-61 | 6-2 | .750 | - | | PNC Arena · Raleigh, NC |
| 9 | Tue Dec 12 | vs UT Martin | W81-67 | 7-2 | .778 | - | ACC Network | PNC Arena · Raleigh, NC |
| 10 | Sat Dec 16 | at #12Tennessee | L70-79 | 7-3 | .700 | - | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 11 | Wed Dec 20 | vs Saint Louis | W82-70 | 8-3 | .727 | - | | PNC Arena · Raleigh, NC |
| 12 | Sat Dec 23 | vs Detroit Mercy | W83-66 | 9-3 | .750 | - | ACC Network | PNC Arena · Raleigh, NC |
| 13 | Wed Jan 3 | at Notre Dame | W54-52 | 10-3 | .769 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 14 | Sat Jan 6 | vs Virginia | W76-60 | 11-3 | .786 | - | ACC Network | PNC Arena · Raleigh, NC |
| 15 | Wed Jan 10 | vs #7UNC | L54-67 | 11-4 | .733 | - | ESPN | PNC Arena · Raleigh, NC |
| 16 | Sat Jan 13 | at Louisville | W89-83 | 12-4 | .750 | - | The CW Network | KFC Yum! Center · Louisville, KY |
| 17 | Tue Jan 16 | vs Wake Forest | W83-76 | 13-4 | .765 | - | ACC Network | PNC Arena · Raleigh, NC |
| 18 | Sat Jan 20 | vs Virginia Tech | L78-84 | 13-5 | .722 | - | The CW Network | PNC Arena · Raleigh, NC |
| 19 | Wed Jan 24 | at Virginia | L53-59 (OT) | 13-6 | .684 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 20 | Sat Jan 27 | at Syracuse | L65-77 | 13-7 | .650 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 21 | Tue Jan 30 | vs Miami | W74-68 | 14-7 | .667 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 22 | Sat Feb 3 | vs Georgia Tech | W82-76 | 15-7 | .682 | - | The CW Network | PNC Arena · Raleigh, NC |
| 23 | Wed Feb 7 | vs Pitt | L64-67 | 15-8 | .652 | - | ESPNU | PNC Arena · Raleigh, NC |
| 24 | Sat Feb 10 | at Wake Forest | L79-83 | 15-9 | .625 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 25 | Sat Feb 17 | at Clemson | W78-77 | 16-9 | .640 | - | The CW Network | Littlejohn Coliseum · Clemson, SC |
| 26 | Tue Feb 20 | vs Syracuse | L83-87 | 16-10 | .615 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 27 | Sat Feb 24 | vs Boston College | W81-70 | 17-10 | .630 | - | ACC Network | PNC Arena · Raleigh, NC |
| 28 | Tue Feb 27 | at Florida St | L83-90 | 17-11 | .607 | - | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 29 | Sat Mar 2 | at #9UNC | L70-79 | 17-12 | .586 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 30 | Mon Mar 4 | vs #9Duke | L64-79 | 17-13 | .567 | - | ESPN | PNC Arena · Raleigh, NC |
| 31 | Sat Mar 9 | at Pitt | L73-81 | 17-14 | .548 | - | The CW Network | Petersen Events Center · Pittsburgh, PA |
| 32 | Tue Mar 12 | vs Louisville | W94-85 | 18-14 | .563 | - | ACC Network | Capital One Arena · Washington, D.C. |
| 33 | Wed Mar 13 | at Syracuse | W83-65 | 19-14 | .576 | - | ESPN2 | Capital One Arena · Washington, D.C. |
| 34 | Thu Mar 14 | at #11Duke | W74-69 | 20-14 | .588 | - | ESPN | Capital One Arena · Washington, D.C. |
| 35 | Fri Mar 15 | at Virginia | W73-65 (OT) | 21-14 | .600 | - | ESPN2 | Capital One Arena · Washington, D.C. |
| 36 | Sat Mar 16 | at #4UNC | W84-76 | 22-14 | .611 | - | ESPN | Capital One Arena · Washington, D.C. |
| 37 | Thu Mar 21 | at #6Texas Tech | W80-67 | 23-14 | .622 | #11 | CBS | United Supermarkets Arena · Lubbock, TX |
| 38 | Sat Mar 23 | vs #14Oakland | W79-73 (OT) | 24-14 | .632 | #11 | TBS | PNC Arena · Raleigh, NC |
| 39 | Fri Mar 29 | at #2Marquette | W67-58 | 25-14 | .641 | #11 | CBS | Fiserv Forum · Milwaukee, WI |
| 40 | Sun Mar 31 | at #4Duke | W76-64 | 26-14 | .650 | #11 | CBS | Cameron Indoor Stadium · Durham, NC |
| 41 | Sat Apr 6 | at #1Purdue | L50-63 | 26-15 | .634 | #11 | TBS | State Farm Stadium · Glendale, AZ |