| 1 | Mon Nov 7 | vs Austin Peay | W99-50 | 1-0 | 1.000 | - | | PNC Arena · Raleigh, NC |
| 2 | Fri Nov 11 | vs Campbell | W73-67 | 2-0 | 1.000 | - | | PNC Arena · Raleigh, NC |
| 3 | Tue Nov 15 | vs FIU | W107-74 | 3-0 | 1.000 | - | | PNC Arena · Raleigh, NC |
| 4 | Sat Nov 19 | vs Elon | W74-63 | 4-0 | 1.000 | - | | PNC Arena · Raleigh, NC |
| 5 | Wed Nov 23 | at Kansas | L74-80 | 4-1 | .800 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 6 | Thu Nov 24 | vs Dayton | W76-64 | 5-1 | .833 | - | ESPNEWS | PNC Arena · Raleigh, NC |
| 7 | Fri Nov 25 | vs Butler | W76-61 | 6-1 | .857 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 8 | Tue Nov 29 | vs William & Mary | W85-64 | 7-1 | .875 | - | | PNC Arena · Raleigh, NC |
| 9 | Fri Dec 2 | vs Pitt | L60-68 | 7-2 | .778 | - | ACC Network | PNC Arena · Raleigh, NC |
| 10 | Tue Dec 6 | vs Coppin St | W94-72 | 8-2 | .800 | - | | PNC Arena · Raleigh, NC |
| 11 | Sat Dec 10 | at Miami | L73-80 | 8-3 | .727 | - | | Watsco Center · Coral Gables, FL |
| 12 | Tue Dec 13 | vs Furman | W92-73 | 9-3 | .750 | - | ACC Network | PNC Arena · Raleigh, NC |
| 13 | Sat Dec 17 | at Vanderbilt | W70-66 | 10-3 | .769 | - | CBS | Memorial Gymnasium (TN) · Nashville, TN |
| 14 | Thu Dec 22 | vs Louisville | W76-64 | 11-3 | .786 | - | ACC Network | PNC Arena · Raleigh, NC |
| 15 | Fri Dec 30 | at Clemson | L64-78 | 11-4 | .733 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 16 | Wed Jan 4 | vs #16Duke | W84-60 | 12-4 | .750 | - | ACC Network | PNC Arena · Raleigh, NC |
| 17 | Sat Jan 7 | at Virginia Tech | W73-69 | 13-4 | .765 | - | | Cassell Coliseum · Blacksburg, VA |
| 18 | Sat Jan 14 | vs#16Miami | W83-81 (OT) | 14-4 | .778 | - | | PNC Arena · Raleigh, NC |
| 19 | Tue Jan 17 | at Georgia Tech | W78-66 | 15-4 | .789 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 20 | Sat Jan 21 | at UNC | L69-80 | 15-5 | .750 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 21 | Tue Jan 24 | vs Notre Dame | W85-82 | 16-5 | .762 | - | ACC Network | PNC Arena · Raleigh, NC |
| 22 | Sat Jan 28 | at Wake Forest | W79-77 | 17-5 | .773 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 23 | Wed Feb 1 | vs Florida St | W94-66 | 18-5 | .783 | - | ACC Network | PNC Arena · Raleigh, NC |
| 24 | Sat Feb 4 | vsGeorgia Tech | W72-64 | 19-5 | .792 | - | ACC Network | PNC Arena · Raleigh, NC |
| 25 | Tue Feb 7 | at #8Virginia | L50-63 | 19-6 | .760 | #22 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 26 | Sat Feb 11 | at Boston College | W92-62 | 20-6 | .769 | #22 | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 27 | Tue Feb 14 | at Syracuse | L72-75 | 20-7 | .741 | #23 | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 28 | Sun Feb 19 | vsUNC | W77-69 | 21-7 | .750 | #23 | ESPN | PNC Arena · Raleigh, NC |
| 29 | Wed Feb 22 | vsWake Forest | W90-74 | 22-7 | .759 | - | | PNC Arena · Raleigh, NC |
| 30 | Sat Feb 25 | vsClemson | L71-96 | 22-8 | .733 | - | | PNC Arena · Raleigh, NC |
| 31 | Tue Feb 28 | atDuke | L67-71 | 22-9 | .710 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 32 | Wed Mar 8 | vsVirginia Tech | W97-77 | 23-9 | .719 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 33 | Thu Mar 9 | atClemson | L54-80 | 23-10 | .697 | - | ESPN | Littlejohn Coliseum · Clemson, SC |
| 34 | Fri Mar 17 | at #6Creighton | L63-72 | 23-11 | .676 | #11 | TNT | CHI Health Center Omaha · Omaha, NE |
