| 1 | Mon Nov 3 | vs NC Central | W114-66 | 1-0 | 1.000 | - | ACC Extra | PNC Arena · Raleigh, NC |
| 2 | Fri Nov 7 | vsUAB | W94-70 | 2-0 | 1.000 | - | ACC Network | PNC Arena · Raleigh, NC |
| 3 | Wed Nov 12 | vsUNC Greensboro | W110-64 | 3-0 | 1.000 | - | ACC Network | PNC Arena · Raleigh, NC |
| 4 | Mon Nov 17 | vsVCU | W85-79 | 4-0 | 1.000 | #25 | ACC Network | PNC Arena · Raleigh, NC |
| 5 | Mon Nov 24 | vsSeton Hall | L74-85 | 4-1 | .800 | #23 | ESPN2 | PNC Arena · Raleigh, NC |
| 6 | Tue Nov 25 | atBoise St | W81-70 | 5-1 | .833 | #23 | ESPN2 | ExtraMile Arena · Boise, ID |
| 7 | Wed Nov 26 | atTexas | L97-102 | 5-2 | .714 | #23 | ESPN2 | Moody Center · Austin, TX |
| 8 | Wed Dec 3 | at20Auburn | L73-83 | 5-3 | .625 | - | ESPN | Neville Arena · Auburn, AL |
| 9 | Sat Dec 6 | vsUNC Asheville | W75-63 | 6-3 | .667 | - | The CW Network | PNC Arena · Raleigh, NC |
| 10 | Wed Dec 10 | vsLiberty | W85-45 | 7-3 | .700 | - | ACC Network | PNC Arena · Raleigh, NC |
| 11 | Sat Dec 13 | vs19Kansas | L76-77 (OT) | 7-4 | .636 | - | ESPN | PNC Arena · Raleigh, NC |
| 12 | Wed Dec 17 | vsTexas So | W108-72 | 8-4 | .667 | - | ACC Extra | PNC Arena · Raleigh, NC |
| 13 | Sun Dec 21 | vsOle Miss | W76-62 | 9-4 | .692 | - | ESPN | Greensboro Coliseum · Greensboro, NC |
| 14 | Wed Dec 31 | vsWake Forest | W70-57 | 10-4 | .714 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 15 | Sat Jan 3 | vs21Virginia | L61-76 | 10-5 | .667 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 16 | Tue Jan 6 | atBoston College | W79-71 | 11-5 | .688 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 17 | Sat Jan 10 | atFlorida St | W113-69 | 12-5 | .706 | - | ACC Extra | Donald L. Tucker Center · Tallahassee, FL |
| 18 | Sat Jan 17 | vsGeorgia Tech | L74-78 | 12-6 | .667 | - | The CW Network | PNC Arena · Raleigh, NC |
| 19 | Tue Jan 20 | at18Clemson | W80-76 (OT) | 13-6 | .684 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 20 | Sat Jan 24 | atPitt | W81-72 | 14-6 | .700 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 21 | Tue Jan 27 | vsSyracuse | W88-68 | 15-6 | .714 | - | ESPNU | PNC Arena · Raleigh, NC |
| 22 | Sat Jan 31 | atWake Forest | W96-78 | 16-6 | .727 | - | ACC Extra | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 23 | Tue Feb 3 | atSMU | W84-83 | 17-6 | .739 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 24 | Sat Feb 7 | vsVirginia Tech | W82-73 | 18-6 | .750 | - | The CW Network | PNC Arena · Raleigh, NC |
| 25 | Mon Feb 9 | at24Louisville | L77-118 | 18-7 | .720 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 26 | Sat Feb 14 | vsMiami | L76-77 | 18-8 | .692 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 27 | Tue Feb 17 | vs16UNC | W82-58 | 19-8 | .704 | - | ESPN | PNC Arena · Raleigh, NC |
| 28 | Tue Feb 24 | at11Virginia | L61-90 | 19-9 | .679 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 29 | Sat Feb 28 | atNotre Dame | L90-96 (OT) | 19-10 | .655 | - | The CW Network | Purcell Pavilion · South Bend, IN |
