| 1 | Mon Nov 3 | vs NC Central | 7:00 PM | 14-19 | .424 | - | | PNC Arena · Raleigh, NC |
| 2 | Fri Nov 7 | vsUAB | 9:00 PM | 24-13 | .649 | - | ACC Network | PNC Arena · Raleigh, NC |
| 3 | Wed Nov 12 | vsUNC Greensboro | 8:00 PM | 20-12 | .625 | - | ACC Network | PNC Arena · Raleigh, NC |
| 4 | Mon Nov 17 | vsVCU | 7:00 PM | 28-7 | .800 | - | ACC Network | PNC Arena · Raleigh, NC |
| 5 | Mon Nov 24 | vsSeton Hall | 2:30 PM | 7-25 | .219 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 6 | Wed Dec 3 | at#20Auburn | 9:00 PM | 32-6 | .842 | - | ESPN | Neville Arena · Auburn, AL |
| 7 | Sat Dec 6 | vsUNC Asheville | TBD | 21-11 | .656 | - | | PNC Arena · Raleigh, NC |
| 8 | Wed Dec 10 | vsLiberty | 7:00 PM | 28-7 | .800 | - | ACC Network | PNC Arena · Raleigh, NC |
| 9 | Sat Dec 13 | vs#19Kansas | 5:30 PM | 21-13 | .618 | - | ESPN | PNC Arena · Raleigh, NC |
| 10 | Wed Dec 17 | vsTexas So | TBD | 15-17 | .469 | - | | PNC Arena · Raleigh, NC |
| 11 | Sun Dec 21 | vsOle Miss | 1:00 PM | 24-12 | .667 | - | ESPN | PNC Arena · Raleigh, NC |
| 12 | Wed Dec 31 | vsWake Forest | 12:00 PM | 21-11 | .656 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 13 | Sat Jan 3 | vsVirginia | 11:00 AM | 15-17 | .469 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 14 | Tue Jan 6 | atBoston College | 9:00 PM | 12-19 | .387 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 15 | Sat Jan 10 | atFlorida St | 12:00 PM | 17-15 | .531 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 16 | Sat Jan 17 | vsGeorgia Tech | TBD | 17-17 | .500 | - | | PNC Arena · Raleigh, NC |
| 17 | Tue Jan 20 | atClemson | 7:00 PM | 27-7 | .794 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 18 | Sat Jan 24 | atPitt | TBD | 17-15 | .531 | - | | Petersen Events Center · Pittsburgh, PA |
| 19 | Tue Jan 27 | vsSyracuse | TBD | 14-19 | .424 | - | | PNC Arena · Raleigh, NC |
| 20 | Sat Jan 31 | atWake Forest | TBD | 21-11 | .656 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 21 | Tue Feb 3 | atSMU | TBD | 24-11 | .686 | - | | Moody Coliseum · Dallas, TX |
| 22 | Sat Feb 7 | vsVirginia Tech | TBD | 13-19 | .406 | - | | PNC Arena · Raleigh, NC |
| 23 | Mon Feb 9 | at#11Louisville | 7:00 PM | 27-8 | .771 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 24 | Sat Feb 14 | vsMiami | 4:00 PM | 7-24 | .226 | - | | PNC Arena · Raleigh, NC |
| 25 | Tue Feb 17 | vs#25UNC | TBD | 23-14 | .622 | - | | PNC Arena · Raleigh, NC |
| 26 | Tue Feb 24 | atVirginia | 7:00 PM | 15-17 | .469 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 27 | Sat Feb 28 | atNotre Dame | TBD | 15-18 | .455 | - | | Purcell Pavilion · South Bend, IN |
| 28 | Mon Mar 2 | vs#6Duke | 7:00 PM | 35-4 | .897 | - | ESPN | PNC Arena · Raleigh, NC |
| 29 | Sat Mar 7 | vsStanford | TBD | 21-14 | .600 | - | | PNC Arena · Raleigh, NC |
