| 1 | Wed Nov 25 | vs Charleston So | W95-61 | 1-0 | 1.000 | - | ACC Network | PNC Arena · Raleigh, NC |
| 2 | Fri Nov 27 | vsNorth Florida | W86-51 | 2-0 | 1.000 | - | | PNC Arena · Raleigh, NC |
| 4 | Thu Dec 3 | vsUMass Lowell | W90-59 | 3-0 | 1.000 | - | ESPNU | PNC Arena · Raleigh, NC |
| 8 | Thu Dec 17 | atSaint Louis | L69-80 | 3-1 | .750 | - | | Chaifetz Arena · St. Louis, MO |
| 9 | Sat Dec 19 | vsCampbell | W69-50 | 4-1 | .800 | - | ACC Network | PNC Arena · Raleigh, NC |
| 10 | Tue Dec 22 | vs17UNC | W79-76 | 5-1 | .833 | - | ACC Network | PNC Arena · Raleigh, NC |
| 11 | Wed Dec 30 | vsBoston College | W79-76 | 6-1 | .857 | - | ACC Network | PNC Arena · Raleigh, NC |
| 12 | Tue Jan 5 | at19Clemson | L70-74 (OT) | 6-2 | .750 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 13 | Sat Jan 9 | vsMiami | L59-64 | 6-3 | .667 | - | | PNC Arena · Raleigh, NC |
| 14 | Wed Jan 13 | atFlorida St | L73-105 | 6-4 | .600 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 16 | Wed Jan 20 | at13Virginia | PPD | 14-11 | .560 | - | | John Paul Jones Arena · Charlottesville, VA |
| 17 | Sat Jan 23 | atUNC | L76-86 | 6-5 | .545 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 18 | Wed Jan 27 | vsWake Forest | W72-67 | 7-5 | .583 | - | ACC Network | PNC Arena · Raleigh, NC |
| 19 | Sun Jan 31 | atSyracuse | L73-76 | 7-6 | .538 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 20 | Wed Feb 3 | vs14Virginia | L57-64 | 7-7 | .500 | - | ACC Network | PNC Arena · Raleigh, NC |
| 21 | Sat Feb 6 | atBoston College | W81-65 | 8-7 | .533 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 22 | Tue Feb 9 | vsSyracuse | L68-77 | 8-8 | .500 | - | ACC Network | PNC Arena · Raleigh, NC |
| 23 | Sat Feb 13 | vsDuke | L53-69 | 8-9 | .471 | - | ESPN | PNC Arena · Raleigh, NC |
| 24 | Wed Feb 17 | atPitt | W74-73 | 9-9 | .500 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 25 | Sat Feb 20 | atWake Forest | W80-62 | 10-9 | .526 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 26 | Wed Feb 24 | at15Virginia | W68-61 | 11-9 | .550 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 27 | Sun Feb 28 | vsPitt | W65-62 | 12-9 | .571 | - | ACC Network | PNC Arena · Raleigh, NC |
| 28 | Wed Mar 3 | atNotre Dame | W80-69 | 13-9 | .591 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 30 | Wed Mar 10 | atSyracuse | L68-89 | 13-10 | .565 | - | ACC Network | Greensboro Coliseum · Greensboro, NC |
| 25 | Thu Mar 18 | at2Davidson | W75-61 | 14-10 | .583 | #3 | ESPN | The Super Pit · Denton, TX |
| 26 | Thu Mar 25 | at1Colorado St | L61-65 | 14-11 | .560 | #3 | ESPN | Moby Arena · Fort Collins, CO |
