| 10 | Sun Dec 7 | vs Hofstra | 4:00 PM | 5-4 | .556 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 11 | Sat Dec 13 | atVillanova | 4:30 PM | 6-1 | .857 | - | TNT | Finneran Pavilion · Villanova, PA |
| 12 | Wed Dec 17 | vsBinghamton | 7:00 PM | 3-6 | .333 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 13 | Sun Dec 21 | atPenn State | 12:00 PM | 8-1 | .889 | - | BTN | Bryce Jordan Center · University Park, PA |
| 14 | Tue Dec 30 | atMiami | 7:00 PM | 7-2 | .778 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 15 | Sat Jan 3 | vsClemson | 12:00 PM | 7-2 | .778 | - | The CW Network | Petersen Events Center · Pittsburgh, PA |
| 16 | Sat Jan 10 | vsSyracuse | 2:00 PM | 5-3 | .625 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 17 | Wed Jan 14 | atGeorgia Tech | 7:00 PM | 5-4 | .556 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 18 | Sat Jan 17 | vs#6Louisville | 8:00 PM | 7-1 | .875 | - | | Petersen Events Center · Pittsburgh, PA |
| 19 | Wed Jan 21 | atBoston College | 7:00 PM | 4-5 | .444 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 20 | Sat Jan 24 | vsNC State | 12:00 PM | 5-3 | .625 | - | | Petersen Events Center · Pittsburgh, PA |
| 21 | Tue Jan 27 | vsWake Forest | 6:00 PM | 6-3 | .667 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 22 | Sat Jan 31 | atClemson | 12:00 PM | 7-2 | .778 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 23 | Tue Feb 3 | atVirginia | 9:00 PM | 7-1 | .875 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 24 | Sat Feb 7 | vsSMU | 3:45 PM | 8-1 | .889 | - | | Petersen Events Center · Pittsburgh, PA |
| 25 | Tue Feb 10 | vs#4Duke | 9:00 PM | 9-0 | 1.000 | - | | Petersen Events Center · Pittsburgh, PA |
| 26 | Sat Feb 14 | at#16UNC | 2:00 PM | 7-1 | .875 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 27 | Sat Feb 21 | vsNotre Dame | 2:00 PM | 6-3 | .667 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 28 | Wed Feb 25 | atStanford | 8:00 PM | 7-1 | .875 | - | ACC Network | Maples Pavilion · Stanford, CA |
| 29 | Sat Feb 28 | atCalifornia | 4:00 PM | 7-1 | .875 | - | ACC Network | Haas Pavilion · Berkeley, CA |
| 30 | Wed Mar 4 | vsFlorida St | 9:00 PM | 5-3 | .625 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 31 | Sat Mar 7 | atSyracuse | 5:00 PM | 5-3 | .625 | - | | JMA Wireless Dome · Syracuse, NY |
