| 1 | Mon Nov 4 | vs Radford | W96-56 | 1-0 | 1.000 | - | ESPN+ | Petersen Events Center · Pittsburgh, PA |
| 2 | Fri Nov 8 | vs Murray St | W83-68 | 2-0 | 1.000 | - | ESPN+ | Petersen Events Center · Pittsburgh, PA |
| 3 | Mon Nov 11 | vs Gardner-Webb | W83-64 | 3-0 | 1.000 | - | ESPN+ | Petersen Events Center · Pittsburgh, PA |
| 4 | Fri Nov 15 | vs West Virginia | W86-62 | 4-0 | 1.000 | - | ESPN+ | Petersen Events Center · Pittsburgh, PA |
| 5 | Mon Nov 18 | vs VMI | W93-48 | 5-0 | 1.000 | - | ESPN+ | Petersen Events Center · Pittsburgh, PA |
| 6 | Fri Nov 22 | vs LSU | W74-63 | 6-0 | 1.000 | - | CBS | Petersen Events Center · Pittsburgh, PA |
| 7 | Sun Nov 24 | vs #19Wisconsin | L75-81 | 6-1 | .857 | - | | Petersen Events Center · Pittsburgh, PA |
| 8 | Fri Nov 29 | at Ohio State | W91-90 (OT) | 7-1 | .875 | - | Peacock | Value City Arena · Columbus, OH |
| 9 | Wed Dec 4 | at Mississippi St | L57-90 | 7-2 | .778 | #18 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 10 | Sat Dec 7 | at Virginia Tech | W64-59 | 8-2 | .800 | #18 | ESPNU | Cassell Coliseum · Blacksburg, VA |
| 11 | Wed Dec 11 | vs E Kentucky | W96-56 | 9-2 | .818 | - | ESPN+ | Petersen Events Center · Pittsburgh, PA |
| 12 | Sat Dec 21 | vs Sam Houston | W110-78 | 10-2 | .833 | - | ESPN+ | Petersen Events Center · Pittsburgh, PA |
| 13 | Wed Jan 1 | vs California | W86-74 | 11-2 | .846 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 14 | Sat Jan 4 | vs Stanford | W83-68 | 12-2 | .857 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 15 | Tue Jan 7 | at #4Duke | L47-76 | 12-3 | .800 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 16 | Sat Jan 11 | vs Louisville | L78-82 | 12-4 | .750 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 17 | Wed Jan 15 | at Florida St | L70-82 | 12-5 | .706 | - | ESPNU | Donald L. Tucker Center · Tallahassee, FL |
| 18 | Sat Jan 18 | vs Clemson | L75-78 (OT) | 12-6 | .667 | - | The CW Network | Petersen Events Center · Pittsburgh, PA |
| 19 | Sat Jan 25 | at Syracuse | W77-73 | 13-6 | .684 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 20 | Tue Jan 28 | vs UNC | W73-65 | 14-6 | .700 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 21 | Sat Feb 1 | at Wake Forest | L74-76 | 14-7 | .667 | - | ESPN2 | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 22 | Mon Feb 3 | vs Virginia | L57-73 | 14-8 | .636 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 23 | Sat Feb 8 | atUNC | L66-67 | 14-9 | .609 | - | ESPNU | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Tue Feb 11 | at SMU | L63-83 | 14-10 | .583 | - | ACC Network | Moody Coliseum · Dallas, TX |
| 25 | Sat Feb 15 | vs Miami | W74-65 | 15-10 | .600 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 26 | Tue Feb 18 | vsSyracuse | W80-69 | 16-10 | .615 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 27 | Sat Feb 22 | at Notre Dame | L72-76 | 16-11 | .593 | - | The CW Network | Purcell Pavilion · South Bend, IN |
| 28 | Tue Feb 25 | vs Georgia Tech | L67-73 | 16-12 | .571 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 29 | Sat Mar 1 | at#19Louisville | L68-79 | 16-13 | .552 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 30 | Wed Mar 5 | at NC State | L63-71 | 16-14 | .533 | - | ESPNEWS | PNC Arena · Raleigh, NC |
| 31 | Sat Mar 8 | vs Boston College | W93-67 | 17-14 | .548 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 32 | Tue Mar 11 | atNotre Dame | L54-55 | 17-15 | .531 | - | ACC Network | Purcell Pavilion · South Bend, IN |
