| 1 | Mon Nov 7 | vs UT Martin | W80-58 | 1-0 | 1.000 | - | | Petersen Events Center · Pittsburgh, PA |
| 2 | Fri Nov 11 | vs West Virginia | L56-81 | 1-1 | .500 | - | | Petersen Events Center · Pittsburgh, PA |
| 3 | Wed Nov 16 | vs Michigan | L60-91 | 1-2 | .333 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 4 | Thu Nov 17 | at VCU | L67-71 | 1-3 | .250 | - | ESPN2 | Stuart C. Siegel Center · Richmond, VA |
| 5 | Sun Nov 20 | vs Alabama St | W73-54 | 2-3 | .400 | - | | Petersen Events Center · Pittsburgh, PA |
| 6 | Tue Nov 22 | vs Fairleigh | W83-61 | 3-3 | .500 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 7 | Fri Nov 25 | vs William & Mary | W80-64 | 4-3 | .571 | - | | Petersen Events Center · Pittsburgh, PA |
| 8 | Mon Nov 28 | at Northwestern | W87-58 | 5-3 | .625 | - | ESPN2 | Welsh-Ryan Arena · Evanston, IL |
| 9 | Fri Dec 2 | at NC State | W68-60 | 6-3 | .667 | - | ACC Network | PNC Arena · Raleigh, NC |
| 10 | Wed Dec 7 | at Vanderbilt | L74-75 | 6-4 | .600 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 11 | Sat Dec 10 | vs Sacred Heart | W91-66 | 7-4 | .636 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 12 | Sat Dec 17 | vs North Florida | W82-56 | 8-4 | .667 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 13 | Tue Dec 20 | at Syracuse | W84-82 | 9-4 | .692 | - | ESPNU | JMA Wireless Dome · Syracuse, NY |
| 14 | Fri Dec 30 | vs #25UNC | W76-74 | 10-4 | .714 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 15 | Tue Jan 3 | vs #11Virginia | W68-65 | 11-4 | .733 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 16 | Sat Jan 7 | vs Clemson | L74-75 | 11-5 | .688 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 17 | Wed Jan 11 | at #24Duke | L69-77 | 11-6 | .647 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 18 | Sat Jan 14 | at Georgia Tech | W71-60 | 12-6 | .667 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 19 | Wed Jan 18 | at Louisville | W75-54 | 13-6 | .684 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 20 | Sat Jan 21 | vs Florida St | L64-71 | 13-7 | .650 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 21 | Wed Jan 25 | vs Wake Forest | W81-79 | 14-7 | .667 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 22 | Sat Jan 28 | vs #20Miami | W71-68 | 15-7 | .682 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 23 | Wed Feb 1 | atUNC | W65-64 | 16-7 | .696 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Tue Feb 7 | vsLouisville | W91-57 | 17-7 | .708 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 25 | Sat Feb 11 | atFlorida St | W83-75 | 18-7 | .720 | - | ESPNU | Donald L. Tucker Center · Tallahassee, FL |
| 26 | Tue Feb 14 | vs Boston College | W77-58 | 19-7 | .731 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 27 | Sat Feb 18 | at Virginia Tech | L72-79 | 19-8 | .704 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 28 | Tue Feb 21 | vsGeorgia Tech | W76-68 | 20-8 | .714 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 29 | Sat Feb 25 | vsSyracuse | W99-82 | 21-8 | .724 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 30 | Wed Mar 1 | at Notre Dame | L81-88 | 21-9 | .700 | #25 | ESPNU | Purcell Pavilion · South Bend, IN |
| 31 | Sat Mar 4 | at#16Miami | L76-78 | 21-10 | .677 | #25 | ACC Network | Watsco Center · Coral Gables, FL |
| 32 | Wed Mar 8 | vsGeorgia Tech | W89-81 | 22-10 | .688 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 33 | Thu Mar 9 | atDuke | L69-96 | 22-11 | .667 | - | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 34 | Tue Mar 14 | at #11Mississippi St | W60-59 | 23-11 | .676 | #11 | truTV | Humphrey Coliseum · Starkville, MS |
| 35 | Fri Mar 17 | at #6Iowa State | W59-41 | 24-11 | .686 | #11 | truTV | James H. Hilton Coliseum · Ames, IA |
| 36 | Sun Mar 19 | at #3Xavier | L73-84 | 24-12 | .667 | #11 | CBS | Cintas Center · Cincinnati, OH |
