| 1 | Mon Nov 3 | vs Youngstown St | W74-59 | 1-0 | 1.000 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 2 | Fri Nov 7 | vsLongwood | W78-60 | 2-0 | 1.000 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 3 | Mon Nov 10 | vsE Michigan | W78-66 | 3-0 | 1.000 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 4 | Thu Nov 13 | atWest Virginia | L49-71 | 3-1 | .750 | - | FS1 | WVU Coliseum · Morgantown, WV |
| 5 | Mon Nov 17 | vsBucknell | W84-50 | 4-1 | .800 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 6 | Thu Nov 20 | atUCF | L67-77 | 4-2 | .667 | - | ESPN2 | Addition Financial Arena · Orlando, FL |
| 7 | Sun Nov 23 | vsQuinnipiac | L75-83 | 4-3 | .571 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 8 | Fri Nov 28 | vsOhio State | W67-66 | 5-3 | .625 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 9 | Tue Dec 2 | vsTexas A&M | L73-81 | 5-4 | .556 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 10 | Sun Dec 7 | vsHofstra | L73-80 | 5-5 | .500 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 11 | Sat Dec 13 | atVillanova | L61-79 | 5-6 | .455 | - | truTV | Finneran Pavilion · Villanova, PA |
| 12 | Wed Dec 17 | vsBinghamton | W103-63 | 6-6 | .500 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 13 | Sun Dec 21 | atPenn State | W80-46 | 7-6 | .538 | - | BTN | Bryce Jordan Center · University Park, PA |
| 14 | Tue Dec 30 | atMiami | L69-76 | 7-7 | .500 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 15 | Sat Jan 3 | vsClemson | L68-73 | 7-8 | .467 | - | The CW Network | Petersen Events Center · Pittsburgh, PA |
| 16 | Sat Jan 10 | vsSyracuse | L72-83 | 7-9 | .438 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 17 | Wed Jan 14 | atGeorgia Tech | W89-66 | 8-9 | .471 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 18 | Sat Jan 17 | vs20Louisville | L59-100 | 8-10 | .444 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 19 | Wed Jan 21 | atBoston College | L62-65 | 8-11 | .421 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 20 | Sat Jan 24 | vsNC State | L72-81 | 8-12 | .400 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 21 | Tue Jan 27 | vsWake Forest | W80-76 (OT) | 9-12 | .429 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 22 | Sat Jan 31 | at22Clemson | L52-63 | 9-13 | .409 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 23 | Tue Feb 3 | at18Virginia | L47-67 | 9-14 | .391 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 24 | Sat Feb 7 | vsSMU | L67-86 | 9-15 | .375 | - | The CW Network | Petersen Events Center · Pittsburgh, PA |
| 25 | Tue Feb 10 | vs4Duke | L54-70 | 9-16 | .360 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 26 | Sat Feb 14 | at11UNC | L65-79 | 9-17 | .346 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 27 | Sat Feb 21 | vsNotre Dame | W73-68 | 10-17 | .370 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 28 | Wed Feb 25 | atStanford | L67-75 | 10-18 | .357 | - | ACC Network | Maples Pavilion · Stanford, CA |
| 29 | Sat Feb 28 | atCalifornia | W72-56 | 11-18 | .379 | - | ACC Network | Haas Pavilion · Berkeley, CA |
