| 1 | Mon Nov 3 | vs Youngstown St | 7:00 PM | 21-13 | .618 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 2 | Fri Nov 7 | vsLongwood | 7:00 PM | 18-14 | .563 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 3 | Mon Nov 10 | vsE Michigan | 7:00 PM | 16-16 | .500 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 4 | Thu Nov 13 | atWest Virginia | 6:00 PM | 19-13 | .594 | - | FS1 | WVU Coliseum · Morgantown, WV |
| 5 | Mon Nov 17 | vsBucknell | 7:00 PM | 18-15 | .545 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 6 | Thu Nov 20 | vsUCF | 7:00 PM | 20-17 | .541 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 7 | Sun Nov 23 | vsQuinnipiac | 5:00 PM | 20-13 | .606 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 8 | Fri Nov 28 | vsOhio State | 7:00 PM | 17-15 | .531 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 9 | Tue Dec 2 | vsTexas A&M | 7:00 PM | 23-11 | .676 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 10 | Sun Dec 7 | vsHofstra | 4:00 PM | 15-18 | .455 | - | | Petersen Events Center · Pittsburgh, PA |
| 11 | Sat Dec 13 | atVillanova | TBD | 21-15 | .583 | - | | Finneran Pavilion · Villanova, PA |
| 12 | Wed Dec 17 | vsBinghamton | TBD | 15-17 | .469 | - | | Petersen Events Center · Pittsburgh, PA |
| 13 | Sun Dec 21 | atPenn State | 12:00 PM | 16-15 | .516 | - | BTN | Bryce Jordan Center · University Park, PA |
| 14 | Tue Dec 30 | atMiami | 7:00 PM | 7-24 | .226 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 15 | Sat Jan 3 | vsClemson | TBD | 27-7 | .794 | - | | Petersen Events Center · Pittsburgh, PA |
| 16 | Sat Jan 10 | vsSyracuse | 2:00 PM | 14-19 | .424 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 17 | Wed Jan 14 | atGeorgia Tech | 7:00 PM | 17-17 | .500 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 18 | Sat Jan 17 | vs#11Louisville | TBD | 27-8 | .771 | - | | Petersen Events Center · Pittsburgh, PA |
| 19 | Wed Jan 21 | atBoston College | 7:00 PM | 12-19 | .387 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 20 | Sat Jan 24 | vsNC State | TBD | 12-19 | .387 | - | | Petersen Events Center · Pittsburgh, PA |
| 21 | Tue Jan 27 | vsWake Forest | 6:00 PM | 21-11 | .656 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 22 | Sat Jan 31 | atClemson | 12:00 PM | 27-7 | .794 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 23 | Tue Feb 3 | atVirginia | 9:00 PM | 15-17 | .469 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 24 | Sat Feb 7 | vsSMU | TBD | 24-11 | .686 | - | | Petersen Events Center · Pittsburgh, PA |
| 25 | Tue Feb 10 | vs#6Duke | TBD | 35-4 | .897 | - | | Petersen Events Center · Pittsburgh, PA |
| 26 | Sat Feb 14 | at#25UNC | 2:00 PM | 23-14 | .622 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 27 | Sat Feb 21 | vsNotre Dame | 2:00 PM | 15-18 | .455 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 28 | Wed Feb 25 | atStanford | 8:00 PM | 21-14 | .600 | - | ACC Network | Maples Pavilion · Stanford, CA |
| 29 | Sat Feb 28 | atCalifornia | 4:00 PM | 14-19 | .424 | - | ACC Network | Haas Pavilion · Berkeley, CA |
| 30 | Wed Mar 4 | vsFlorida St | 9:00 PM | 17-15 | .531 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 31 | Sat Mar 7 | atSyracuse | TBD | 14-19 | .424 | - | | JMA Wireless Dome · Syracuse, NY |
