| 1 | Mon Nov 6 | vs NC A&T | W100-52 | 1-0 | 1.000 | - | | Petersen Events Center · Pittsburgh, PA |
| 2 | Fri Nov 10 | vs Binghamton | W89-60 | 2-0 | 1.000 | - | | Petersen Events Center · Pittsburgh, PA |
| 3 | Mon Nov 13 | vs FGCU | W86-74 | 3-0 | 1.000 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 4 | Fri Nov 17 | vs Jacksonville | W107-56 | 4-0 | 1.000 | - | | Petersen Events Center · Pittsburgh, PA |
| 5 | Wed Nov 22 | vs Florida | L71-86 | 4-1 | .800 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 6 | Fri Nov 24 | vs Oregon St | W76-51 | 5-1 | .833 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 7 | Tue Nov 28 | vs Missouri | L64-71 | 5-2 | .714 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 8 | Sun Dec 3 | vs Clemson | L70-79 | 5-3 | .625 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 9 | Wed Dec 6 | at West Virginia | W80-63 | 6-3 | .667 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 10 | Sat Dec 9 | vs Canisius | W82-71 | 7-3 | .700 | - | | Petersen Events Center · Pittsburgh, PA |
| 11 | Sat Dec 16 | vs SC State | W86-50 | 8-3 | .727 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 12 | Wed Dec 20 | vs Purdue FW | W62-48 | 9-3 | .750 | - | | Petersen Events Center · Pittsburgh, PA |
| 13 | Sat Dec 30 | at Syracuse | L73-81 | 9-4 | .692 | - | The CW Network | JMA Wireless Dome · Syracuse, NY |
| 14 | Tue Jan 2 | vs #8UNC | L57-70 | 9-5 | .643 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 15 | Sat Jan 6 | at Louisville | W83-70 | 10-5 | .667 | - | The CW Network | KFC Yum! Center · Louisville, KY |
| 16 | Tue Jan 9 | vs #11Duke | L53-75 | 10-6 | .625 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 17 | Tue Jan 16 | vsSyracuse | L58-69 | 10-7 | .588 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 18 | Sat Jan 20 | at#7Duke | W80-76 | 11-7 | .611 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 19 | Tue Jan 23 | at Georgia Tech | W72-64 | 12-7 | .632 | - | ESPNU | McCamish Pavilion · Atlanta, GA |
| 20 | Sat Jan 27 | at Miami | L68-72 | 12-8 | .600 | - | The CW Network | Watsco Center · Coral Gables, FL |
| 21 | Wed Jan 31 | vs Wake Forest | W77-72 | 13-8 | .619 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 22 | Sat Feb 3 | vs Notre Dame | W70-60 | 14-8 | .636 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 23 | Wed Feb 7 | at NC State | W67-64 | 15-8 | .652 | - | ESPNU | PNC Arena · Raleigh, NC |
| 24 | Tue Feb 13 | at #21Virginia | W74-63 | 16-8 | .667 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 25 | Sat Feb 17 | vsLouisville | W86-59 | 17-8 | .680 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 26 | Tue Feb 20 | atWake Forest | L58-91 | 17-9 | .654 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 27 | Sat Feb 24 | vs Virginia Tech | W79-64 | 18-9 | .667 | - | | Petersen Events Center · Pittsburgh, PA |
| 28 | Tue Feb 27 | atClemson | L62-69 | 18-10 | .643 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 29 | Sat Mar 2 | at Boston College | W90-65 | 19-10 | .655 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 30 | Tue Mar 5 | vs Florida St | W88-73 | 20-10 | .667 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 31 | Sat Mar 9 | vsNC State | W81-73 | 21-10 | .677 | - | The CW Network | Petersen Events Center · Pittsburgh, PA |
| 32 | Thu Mar 14 | vsWake Forest | W81-69 | 22-10 | .688 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 33 | Fri Mar 15 | at#4UNC | L65-72 | 22-11 | .667 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
