| 1 | Wed Nov 25 | vs St Francis PA | L70-80 | -16 | 0-1 | .000 | - | | Petersen Events Center · Pittsburgh, PA |
| 2 | Sat Nov 28 | vsDrexel | W83-74 | -10 | 1-1 | .500 | - | | Petersen Events Center · Pittsburgh, PA |
| 3 | Sat Dec 5 | vsN Illinois | W89-59 | -15 | 2-1 | .667 | - | | Petersen Events Center · Pittsburgh, PA |
| 4 | Wed Dec 9 | atNorthwestern | W71-70 | +3 | 3-1 | .750 | - | ESPN | Welsh-Ryan Arena · Evanston, IL |
| 5 | Sat Dec 12 | vsGardner-Webb | W67-50 | -12½ | 4-1 | .800 | - | | Petersen Events Center · Pittsburgh, PA |
| 6 | Wed Dec 16 | atMiami | W70-55 | -4½ | 5-1 | .833 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 7 | Tue Dec 22 | vsLouisville | L54-64 | +6 | 5-2 | .714 | - | | Petersen Events Center · Pittsburgh, PA |
| 9 | Wed Jan 6 | atSyracuse | W63-60 | +11 | 6-2 | .750 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 10 | Sat Jan 9 | vs25Florida St | PPD | - | 10-12 | .455 | - | | Petersen Events Center · Pittsburgh, PA |
| 11 | Wed Jan 13 | atGeorgia Tech | PPD | - | 10-12 | .455 | - | | McCamish Pavilion · Atlanta, GA |
| 12 | Sat Jan 16 | vsSyracuse | W96-76 | +3½ | 7-2 | .778 | - | | Petersen Events Center · Pittsburgh, PA |
| 13 | Tue Jan 19 | vsDuke | W79-73 | +4½ | 8-2 | .800 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 15 | Sat Jan 23 | atWake Forest | L75-76 | -2½ | 8-3 | .727 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 16 | Tue Jan 26 | vsUNC | L65-75 | +3½ | 8-4 | .667 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 17 | Sun Jan 31 | vsNotre Dame | L58-84 | -3½ | 8-5 | .615 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 18 | Wed Feb 3 | vs16Virginia Tech | W83-72 | +3½ | 9-5 | .643 | - | | Petersen Events Center · Pittsburgh, PA |
| 19 | Sat Feb 6 | at14Virginia | L66-73 | +11 | 9-6 | .600 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 21 | Sun Feb 14 | atGeorgia Tech | L65-71 | +5 | 9-7 | .563 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 22 | Wed Feb 17 | vsNC State | L73-74 | -4½ | 9-8 | .529 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 23 | Sat Feb 20 | vs16Florida St | L72-79 | +7 | 9-9 | .500 | - | | Petersen Events Center · Pittsburgh, PA |
| 25 | Sun Feb 28 | atNC State | L62-65 | +6½ | 9-10 | .474 | - | ACC Network | Lenovo Center · Raleigh, NC |
| 26 | Tue Mar 2 | vsWake Forest | W70-57 | -4½ | 10-10 | .500 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 27 | Sat Mar 6 | atClemson | L62-77 | +9 | 10-11 | .476 | - | | Littlejohn Coliseum · Clemson, SC |
| 28 | Tue Mar 9 | vsMiami | L73-79 | -3½ | 10-12 | .455 | - | ACC Network | Greensboro Coliseum · Greensboro, NC |
