| 1 | Tue Nov 9 | vs The Citadel | L63-78 | 0-1 | .000 | - | | Petersen Events Center · Pittsburgh, PA |
| 2 | Fri Nov 12 | at West Virginia | L59-74 | 0-2 | .000 | - | ESPNU | WVU Coliseum · Morgantown, WV |
| 3 | Tue Nov 16 | vs UNC Wilmington | W59-51 | 1-2 | .333 | - | | Petersen Events Center · Pittsburgh, PA |
| 4 | Fri Nov 19 | vs Towson | W63-59 | 2-2 | .500 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 5 | Wed Nov 24 | vs Vanderbilt | L52-68 | 2-3 | .400 | - | | Petersen Events Center · Pittsburgh, PA |
| 6 | Sat Nov 27 | vs UMBC | L77-87 | 2-4 | .333 | - | | Petersen Events Center · Pittsburgh, PA |
| 7 | Tue Nov 30 | vs Minnesota | L53-54 | 2-5 | .286 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 8 | Fri Dec 3 | at Virginia | L56-57 | 2-6 | .250 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 9 | Thu Dec 9 | vs Colgate | W71-68 | 3-6 | .333 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 10 | Sun Dec 12 | vs Monmouth | L52-56 | 3-7 | .300 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 11 | Sat Dec 18 | vs St John's | W59-57 | 4-7 | .364 | - | FS1 | Petersen Events Center · Pittsburgh, PA |
| 12 | Tue Dec 21 | vs Jacksonville | W64-55 | 5-7 | .417 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 13 | Tue Dec 28 | vs Notre Dame | L67-68 | 5-8 | .385 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 14 | Sat Jan 1 | at Virginia Tech | PPD | 11-21 | .344 | - | | Cassell Coliseum · Blacksburg, VA |
| 15 | Wed Jan 5 | at Louisville | L72-75 | 5-9 | .357 | - | ESPNU | KFC Yum! Center · Louisville, KY |
| 16 | Sat Jan 8 | vs Boston College | W69-67 | 6-9 | .400 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 17 | Tue Jan 11 | at Syracuse | L61-77 | 6-10 | .375 | - | ESPNU | JMA Wireless Dome · Syracuse, NY |
| 18 | Sat Jan 15 | vsLouisville | W65-53 | 7-10 | .412 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 19 | Wed Jan 19 | vsVirginia | L61-66 | 7-11 | .389 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 20 | Sat Jan 22 | at Clemson | L48-75 | 7-12 | .368 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 21 | Tue Jan 25 | vsSyracuse | W64-53 | 8-12 | .400 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 22 | Sun Jan 30 | atBoston College | L56-69 | 8-13 | .381 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 23 | Wed Feb 2 | at Wake Forest | L75-91 | 8-14 | .364 | - | ESPN2 | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 24 | Sat Feb 5 | vsVirginia Tech | L71-76 | 8-15 | .348 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 25 | Mon Feb 7 | atVirginia Tech | L47-74 | 8-16 | .333 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 26 | Wed Feb 9 | at Florida St | W56-51 | 9-16 | .360 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 27 | Sat Feb 12 | vs NC State | W71-69 | 10-16 | .385 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 28 | Wed Feb 16 | at UNC | W76-67 | 11-16 | .407 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 29 | Sat Feb 19 | vs Georgia Tech | L62-68 | 11-17 | .393 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 30 | Tue Feb 22 | vs Miami | L64-85 | 11-18 | .379 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 31 | Tue Mar 1 | vs #4Duke | L56-86 | 11-19 | .367 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 32 | Sat Mar 5 | atNotre Dame | L54-78 | 11-20 | .355 | - | ESPNEWS | Purcell Pavilion · South Bend, IN |
| 33 | Tue Mar 8 | vsBoston College | L46-66 | 11-21 | .344 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
