| 1 | Wed Nov 6 | vs Florida St | W63-61 | 1-0 | 1.000 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 2 | Sat Nov 9 | vsNicholls | L70-75 | 1-1 | .500 | - | | Petersen Events Center · Pittsburgh, PA |
| 3 | Tue Nov 12 | atRobert Morris | W71-57 | 2-1 | .667 | - | ESPNU | UPMC Events Center · Moon Township, PA |
| 4 | Fri Nov 15 | vsWest Virginia | L53-68 | 2-2 | .500 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 5 | Mon Nov 18 | vsMonmouth | W63-50 | 3-2 | .600 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 6 | Thu Nov 21 | vsAR-Pine Bluff | W66-41 | 4-2 | .667 | - | | Petersen Events Center · Pittsburgh, PA |
| 7 | Mon Nov 25 | atKansas St | W63-59 | 5-2 | .714 | - | FS1 | Bramlage Coliseum · Manhattan, KS |
| 8 | Wed Nov 27 | vsNorthwestern | W72-59 | 6-2 | .750 | - | | Petersen Events Center · Pittsburgh, PA |
| 9 | Tue Dec 3 | vsRutgers | W71-60 | 7-2 | .778 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 10 | Fri Dec 6 | at1Louisville | L46-64 | 7-3 | .700 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 11 | Mon Dec 16 | vsN Illinois | W59-50 | 8-3 | .727 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 12 | Fri Dec 20 | vsBinghamton | W79-53 | 9-3 | .750 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 13 | Mon Dec 30 | vsCanisius | W87-79 | 10-3 | .769 | - | | Petersen Events Center · Pittsburgh, PA |
| 14 | Sat Jan 4 | vsWake Forest | L65-69 | 10-4 | .714 | - | | Petersen Events Center · Pittsburgh, PA |
| 15 | Wed Jan 8 | atUNC | W73-65 | 11-4 | .733 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 16 | Sun Jan 12 | atMiami | L58-66 | 11-5 | .688 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 17 | Tue Jan 14 | vs11Louisville | L68-73 (OT) | 11-6 | .647 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 18 | Sat Jan 18 | vsUNC | W66-52 | 12-6 | .667 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 19 | Wed Jan 22 | vsBoston College | W74-72 | 13-6 | .684 | - | | Petersen Events Center · Pittsburgh, PA |
| 20 | Sat Jan 25 | atSyracuse | L61-69 | 13-7 | .650 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 21 | Tue Jan 28 | at9Duke | L67-79 | 13-8 | .619 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 22 | Sun Feb 2 | vsMiami | W62-57 | 14-8 | .636 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 23 | Wed Feb 5 | atNotre Dame | L72-80 | 14-9 | .609 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 24 | Sat Feb 8 | vsGeorgia Tech | W73-64 | 15-9 | .625 | - | | Petersen Events Center · Pittsburgh, PA |
| 25 | Wed Feb 12 | vsClemson | L52-72 | 15-10 | .600 | - | | Petersen Events Center · Pittsburgh, PA |
| 26 | Sat Feb 15 | atVirginia Tech | L57-67 | 15-11 | .577 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 27 | Tue Feb 18 | at8Florida St | L67-82 | 15-12 | .556 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 28 | Sat Feb 22 | vsVirginia | L56-59 | 15-13 | .536 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 29 | Wed Feb 26 | vsSyracuse | L49-72 | 15-14 | .517 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 30 | Sat Feb 29 | atNC State | L73-77 | 15-15 | .500 | - | ACC Network | PNC Arena · Raleigh, NC |
| 31 | Wed Mar 4 | atGeorgia Tech | L57-73 | 15-16 | .484 | - | | McCamish Pavilion · Atlanta, GA |
| 32 | Tue Mar 10 | atWake Forest | W81-72 | 16-16 | .500 | - | ACC Network | Greensboro Coliseum · Greensboro, NC |
| 33 | Wed Mar 11 | atNC State | L58-73 | 16-17 | .485 | - | ESPN | Greensboro Coliseum · Greensboro, NC |
