| 1 | Mon Nov 4 | vs Lehigh | W90-46 | 1-0 | 1.000 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 2 | Sat Nov 9 | at Dayton | L66-71 | 1-1 | .500 | - | ESPN+ | UD Arena · Dayton, OH |
| 3 | Tue Nov 12 | vs UIC | W83-74 | 2-1 | .667 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 4 | Fri Nov 15 | vs E Illinois | W67-58 (OT) | 3-1 | .750 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 5 | Tue Nov 19 | vs Montana St | W72-69 | 4-1 | .800 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 6 | Fri Nov 22 | vs Pepperdine | W68-50 | 5-1 | .833 | - | B1G+ | Welsh-Ryan Arena · Evanston, IL |
| 7 | Thu Nov 28 | at Butler | L69-71 | 5-2 | .714 | - | CBS | Hinkle Fieldhouse · Indianapolis, IN |
| 8 | Fri Nov 29 | vs UNLV | W66-61 | 6-2 | .750 | - | | Welsh-Ryan Arena · Evanston, IL |
| 9 | Tue Dec 3 | at Iowa | L79-80 | 6-3 | .667 | - | Peacock | Carver-Hawkeye Arena · Iowa City, IA |
| 10 | Fri Dec 6 | vs #19Illinois | W70-66 (OT) | 7-3 | .700 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 11 | Sun Dec 15 | vs Georgia Tech | W71-60 | 8-3 | .727 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 12 | Sat Dec 21 | vs DePaul | W84-64 | 9-3 | .750 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 13 | Sun Dec 29 | vs Northeastern | W85-60 | 10-3 | .769 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 14 | Thu Jan 2 | at Penn State | L80-84 | 10-4 | .714 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 15 | Sun Jan 5 | at #20Purdue | L61-79 | 10-5 | .667 | - | BTN | Mackey Arena · West Lafayette, IN |
| 16 | Sun Jan 12 | vs #16Michigan St | L68-78 | 10-6 | .625 | - | FOX | Welsh-Ryan Arena · Evanston, IL |
| 17 | Thu Jan 16 | vs Maryland | W76-74 (OT) | 11-6 | .647 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 18 | Sun Jan 19 | at #20Michigan | L76-80 (OT) | 11-7 | .611 | - | BTN | Crisler Center · Ann Arbor, MI |
| 19 | Wed Jan 22 | vs Indiana | W79-70 | 12-7 | .632 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 20 | Sun Jan 26 | at#17Illinois | L74-83 | 12-8 | .600 | - | BTN | State Farm Center · Champaign, IL |
| 21 | Wed Jan 29 | vs Rutgers | L72-79 | 12-9 | .571 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 22 | Sat Feb 1 | vs #17Wisconsin | L69-75 | 12-10 | .545 | - | FS1 | Welsh-Ryan Arena · Evanston, IL |
| 23 | Tue Feb 4 | vs USC | W77-75 | 13-10 | .565 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 24 | Sat Feb 8 | at Washington | L71-76 | 13-11 | .542 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 25 | Tue Feb 11 | at Oregon | L75-81 | 13-12 | .520 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 26 | Sun Feb 16 | vs Nebraska | L64-68 | 13-13 | .500 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 27 | Thu Feb 20 | at Ohio State | W70-49 | 14-13 | .519 | - | FS1 | Value City Arena · Columbus, OH |
| 28 | Tue Feb 25 | at Minnesota | W75-63 | 15-13 | .536 | - | Peacock | Williams Arena · Minneapolis, MN |
| 29 | Fri Feb 28 | vsIowa | W68-57 | 16-13 | .552 | - | FS1 | Welsh-Ryan Arena · Evanston, IL |
| 30 | Mon Mar 3 | vs UCLA | L69-73 | 16-14 | .533 | - | FS1 | Welsh-Ryan Arena · Evanston, IL |
| 31 | Sat Mar 8 | at#13Maryland | L61-74 | 16-15 | .516 | - | Peacock | XFINITY Center · College Park, MD |
| 32 | Wed Mar 12 | atMinnesota | W72-64 | 17-15 | .531 | - | Peacock | Williams Arena · Minneapolis, MN |
| 33 | Thu Mar 13 | at#18Wisconsin | L63-70 | 17-16 | .515 | - | BTN | Kohl Center · Madison, WI |
