| 2 | Wed Dec 2 | vs AR-Pine Bluff | W92-49 | 1-0 | 1.000 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 3 | Sat Dec 5 | vsChicago St | W111-66 | 2-0 | 1.000 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 4 | Wed Dec 9 | vsPitt | L70-71 | 2-1 | .667 | - | ESPN | Welsh-Ryan Arena · Evanston, IL |
| 6 | Tue Dec 15 | vsTBD | W100-48 | 3-1 | .750 | - | | Welsh-Ryan Arena · Evanston, IL |
| 7 | Sun Dec 20 | vs#4Michigan St | W79-65 | 4-1 | .800 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 8 | Wed Dec 23 | atIndiana | W74-67 | 5-1 | .833 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 9 | Sat Dec 26 | vs#23Ohio State | W71-70 | 6-1 | .857 | - | FS1 | Welsh-Ryan Arena · Evanston, IL |
| 10 | Tue Dec 29 | at#10Iowa | L72-87 | 6-2 | .750 | #19 | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 11 | Sun Jan 3 | at#16Michigan | L66-85 | 6-3 | .667 | #19 | | Crisler Center · Ann Arbor, MI |
| 12 | Thu Jan 7 | vs#12Illinois | L56-81 | 6-4 | .600 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 13 | Wed Jan 13 | at#21Ohio State | L71-81 | 6-5 | .545 | - | BTN | Value City Arena · Columbus, OH |
| 14 | Sun Jan 17 | vs#5Iowa | L73-96 | 6-6 | .500 | - | CBS | Welsh-Ryan Arena · Evanston, IL |
| 15 | Wed Jan 20 | at#10Wisconsin | L52-68 | 6-7 | .462 | - | BTN | Kohl Center · Madison, WI |
| 16 | Sat Jan 23 | atPenn State | L78-81 | 6-8 | .429 | - | BTN | Bryce Jordan Center · University Park, PA |
| 17 | Sun Jan 31 | vsRutgers | L56-64 | 6-9 | .400 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 19 | Sat Feb 6 | at#24Purdue | L70-75 | 6-10 | .375 | - | | Mackey Arena · West Lafayette, IN |
| 20 | Wed Feb 10 | vsIndiana | L76-79 (2OT) | 6-11 | .353 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 21 | Sat Feb 13 | at#25Rutgers | L50-64 | 6-12 | .333 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 22 | Tue Feb 16 | at#5Illinois | L66-73 | 6-13 | .316 | - | BTN | State Farm Center · Champaign, IL |
| 23 | Sun Feb 21 | vs#21Wisconsin | L51-68 | 6-14 | .300 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 24 | Thu Feb 25 | atMinnesota | W67-59 | 7-14 | .333 | - | BTN | Williams Arena · Minneapolis, MN |
| 25 | Wed Mar 3 | vsMaryland | W60-55 | 8-14 | .364 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 26 | Sun Mar 7 | vsNebraska | W79-78 | 9-14 | .391 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 27 | Wed Mar 10 | vsMinnesota | L46-51 | 9-15 | .375 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
