| 1 | Mon Nov 3 | vs Oakland | W121-78 | 1-0 | 1.000 | #7 | FS1 | Crisler Center · Ann Arbor, MI |
| 2 | Tue Nov 11 | vsWake Forest | W85-84 (OT) | 2-0 | 1.000 | #6 | FS1 | Crisler Center · Ann Arbor, MI |
| 3 | Fri Nov 14 | atTCU | W67-63 | 3-0 | 1.000 | #6 | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 4 | Wed Nov 19 | vsMTSU | W86-61 | 4-0 | 1.000 | #7 | BTN | Crisler Center · Ann Arbor, MI |
| 5 | Mon Nov 24 | vsSDSU | W94-54 | 5-0 | 1.000 | #7 | truTV | Crisler Center · Ann Arbor, MI |
| 6 | Tue Nov 25 | vs21Auburn | W102-72 | 6-0 | 1.000 | #7 | TNT | Crisler Center · Ann Arbor, MI |
| 7 | Wed Nov 26 | vs12Gonzaga | W101-61 | 7-0 | 1.000 | #7 | TNT | Crisler Center · Ann Arbor, MI |
| 8 | Sat Dec 6 | vsRutgers | W101-60 | 8-0 | 1.000 | #3 | BTN | Crisler Center · Ann Arbor, MI |
| 9 | Tue Dec 9 | vsVillanova | W89-61 | 9-0 | 1.000 | #2 | FS1 | Crisler Center · Ann Arbor, MI |
| 10 | Sat Dec 13 | atMaryland | W101-83 | 10-0 | 1.000 | #2 | FOX | XFINITY Center · College Park, MD |
| 11 | Sun Dec 21 | vsLa Salle | W102-50 | 11-0 | 1.000 | #2 | Peacock | Crisler Center · Ann Arbor, MI |
| 12 | Mon Dec 29 | vsMcNeese | W112-71 | 12-0 | 1.000 | #2 | B1G+ | Crisler Center · Ann Arbor, MI |
| 13 | Fri Jan 2 | vs24USC | W96-66 | 13-0 | 1.000 | #2 | Peacock | Crisler Center · Ann Arbor, MI |
| 14 | Tue Jan 6 | atPenn State | W74-72 | 14-0 | 1.000 | #2 | FS1 | Bryce Jordan Center · University Park, PA |
| 15 | Sat Jan 10 | vsWisconsin | L88-91 | 14-1 | .933 | #2 | CBS | Crisler Center · Ann Arbor, MI |
| 16 | Wed Jan 14 | atWashington | W82-72 | 15-1 | .938 | #4 | BTN | Alaska Airlines Arena · Seattle, WA |
| 17 | Sat Jan 17 | atOregon | W81-71 | 16-1 | .941 | #4 | NBC | Matthew Knight Arena · Eugene, OR |
| 18 | Tue Jan 20 | vsIndiana | W86-72 | 17-1 | .944 | #3 | Peacock | Crisler Center · Ann Arbor, MI |
| 19 | Fri Jan 23 | vsOhio State | W74-62 | 18-1 | .947 | #3 | FOX | Crisler Center · Ann Arbor, MI |
| 20 | Tue Jan 27 | vs5Nebraska | W75-72 | 19-1 | .950 | #3 | Peacock | Crisler Center · Ann Arbor, MI |
| 21 | Fri Jan 30 | at7Michigan St | W83-71 | 20-1 | .952 | #3 | FOX | Breslin Center · East Lansing, MI |
| 22 | Thu Feb 5 | vsPenn State | W110-69 | 21-1 | .955 | #2 | FS1 | Crisler Center · Ann Arbor, MI |
| 23 | Sun Feb 8 | atOhio State | W82-61 | 22-1 | .957 | #2 | CBS | Value City Arena · Columbus, OH |
| 24 | Wed Feb 11 | atNorthwestern | W87-75 | 23-1 | .958 | #2 | BTN | Welsh-Ryan Arena · Evanston, IL |
| 25 | Sat Feb 14 | vsUCLA | W86-56 | 24-1 | .960 | #2 | CBS | Crisler Center · Ann Arbor, MI |
| 26 | Tue Feb 17 | at7Purdue | W91-80 | 25-1 | .962 | #1 | Peacock | Mackey Arena · West Lafayette, IN |
| 27 | Sat Feb 21 | at3Duke | L63-68 | 25-2 | .926 | #1 | ESPN | Capital One Arena · Washington, D.C. |
| 28 | Tue Feb 24 | vsMinnesota | W77-67 | 26-2 | .929 | #3 | BTN | Crisler Center · Ann Arbor, MI |
| 29 | Fri Feb 27 | at10Illinois | W84-70 | 27-2 | .931 | #3 | FOX | State Farm Center · Champaign, IL |
