| 1 | Mon Nov 4 | vs Cleveland St | W101-53 | 1-0 | 1.000 | - | BTN | Crisler Center · Ann Arbor, MI |
| 2 | Sun Nov 10 | at Wake Forest | L70-72 | 1-1 | .500 | - | ESPN2 | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 3 | Fri Nov 15 | vs TCU | W76-64 | 2-1 | .667 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 4 | Mon Nov 18 | vs Miami OH | W94-67 | 3-1 | .750 | - | BTN | Crisler Center · Ann Arbor, MI |
| 5 | Thu Nov 21 | vs Tarleton | W72-49 | 4-1 | .800 | - | BTN | Crisler Center · Ann Arbor, MI |
| 6 | Mon Nov 25 | at Virginia Tech | W75-63 | 5-1 | .833 | - | FS1 | Cassell Coliseum · Blacksburg, VA |
| 7 | Wed Nov 27 | vs #22Xavier | W78-53 | 6-1 | .857 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 8 | Tue Dec 3 | at #11Wisconsin | W67-64 | 7-1 | .875 | - | Peacock | Kohl Center · Madison, WI |
| 9 | Sat Dec 7 | vs Iowa | W85-83 | 8-1 | .889 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 10 | Tue Dec 10 | at Arkansas | L87-89 | 8-2 | .800 | #14 | ESPN | Bud Walton Arena · Fayetteville, AR |
| 11 | Wed Dec 18 | at #14Oklahoma | L86-87 | 8-3 | .727 | #24 | ESPN2 | Lloyd Noble Center · Norman, OK |
| 12 | Sun Dec 22 | vs Purdue FW | W89-58 | 9-3 | .750 | #24 | B1G+ | Crisler Center · Ann Arbor, MI |
| 13 | Sun Dec 29 | vs Western KY | W112-64 | 10-3 | .769 | - | BTN | Crisler Center · Ann Arbor, MI |
| 14 | Sat Jan 4 | at USC | W85-74 | 11-3 | .786 | - | FOX | Galen Center · Los Angeles, CA |
| 15 | Tue Jan 7 | at #22UCLA | W94-75 | 12-3 | .800 | #24 | Peacock | Pauley Pavilion · Los Angeles, CA |
| 16 | Sun Jan 12 | vs Washington | W91-75 | 13-3 | .813 | #24 | BTN | Crisler Center · Ann Arbor, MI |
| 17 | Thu Jan 16 | at Minnesota | L81-84 (OT) | 13-4 | .765 | #20 | FS1 | Williams Arena · Minneapolis, MN |
| 18 | Sun Jan 19 | vs Northwestern | W80-76 (OT) | 14-4 | .778 | #20 | BTN | Crisler Center · Ann Arbor, MI |
| 19 | Fri Jan 24 | at #11Purdue | L64-91 | 14-5 | .737 | #21 | FOX | Mackey Arena · West Lafayette, IN |
| 20 | Mon Jan 27 | vs Penn State | W76-72 | 15-5 | .750 | - | BTN | Crisler Center · Ann Arbor, MI |
| 21 | Sat Feb 1 | at Rutgers | W66-63 | 16-5 | .762 | - | FOX | Jersey Mike’s Arena · Piscataway, NJ |
| 22 | Wed Feb 5 | vs Oregon | W80-76 | 17-5 | .773 | #24 | BTN | Crisler Center · Ann Arbor, MI |
| 23 | Sat Feb 8 | at Indiana | W70-67 | 18-5 | .783 | #24 | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 24 | Tue Feb 11 | vs#7Purdue | W75-73 | 19-5 | .792 | #20 | Peacock | Crisler Center · Ann Arbor, MI |
| 25 | Sun Feb 16 | at Ohio State | W86-83 | 20-5 | .800 | #20 | CBS | Value City Arena · Columbus, OH |
| 26 | Fri Feb 21 | vs #14Michigan St | L62-75 | 20-6 | .769 | #12 | FOX | Crisler Center · Ann Arbor, MI |
| 27 | Mon Feb 24 | at Nebraska | W49-46 | 21-6 | .778 | #15 | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 28 | Thu Feb 27 | vsRutgers | W84-82 | 22-6 | .786 | #15 | Peacock | Crisler Center · Ann Arbor, MI |
| 29 | Sun Mar 2 | vs Illinois | L73-93 | 22-7 | .759 | #15 | CBS | Crisler Center · Ann Arbor, MI |
| 30 | Wed Mar 5 | vs #13Maryland | L65-71 | 22-8 | .733 | #17 | BTN | Crisler Center · Ann Arbor, MI |
| 31 | Sun Mar 9 | at#8Michigan St | L62-79 | 22-9 | .710 | #17 | CBS | Breslin Center · East Lansing, MI |
| 32 | Fri Mar 14 | vs#20Purdue | W86-68 | 23-9 | .719 | #22 | BTN | Crisler Center · Ann Arbor, MI |
| 33 | Sat Mar 15 | at#11Maryland | W81-80 | 24-9 | .727 | #22 | CBS | XFINITY Center · College Park, MD |
| 34 | Sun Mar 16 | vs#18Wisconsin | W59-53 | 25-9 | .735 | #22 | CBS | Crisler Center · Ann Arbor, MI |
| 35 | Thu Mar 20 | vs #12UC San Diego | W68-65 | 26-9 | .743 | #5 | TBS | Crisler Center · Ann Arbor, MI |
| 36 | Sat Mar 22 | at #4Texas A&M | W91-79 | 27-9 | .750 | #5 | CBS | Reed Arena · College Station, TX |
