| 1 | Wed Nov 25 | vs Bowling Green | W96-82 | 1-0 | 1.000 | #25 | ESPN2 | Crisler Center · Ann Arbor, MI |
| 2 | Sun Nov 29 | vsOakland | W81-71 (OT) | 2-0 | 1.000 | #25 | BTN | Crisler Center · Ann Arbor, MI |
| 3 | Wed Dec 2 | vsBall State | W84-65 | 3-0 | 1.000 | - | BTN | Crisler Center · Ann Arbor, MI |
| 4 | Sun Dec 6 | vsUCF | W80-58 | 4-0 | 1.000 | - | BTN | Crisler Center · Ann Arbor, MI |
| 5 | Wed Dec 9 | vsToledo | W91-71 | 5-0 | 1.000 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 6 | Sun Dec 13 | vsPenn State | W62-58 | 6-0 | 1.000 | - | BTN | Crisler Center · Ann Arbor, MI |
| 7 | Fri Dec 25 | atNebraska | W80-69 | 7-0 | 1.000 | #19 | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 8 | Thu Dec 31 | atMaryland | W84-73 | 8-0 | 1.000 | #16 | ESPN | XFINITY Center · College Park, MD |
| 9 | Sun Jan 3 | vs19Northwestern | W85-66 | 9-0 | 1.000 | #16 | | Crisler Center · Ann Arbor, MI |
| 10 | Wed Jan 6 | vs16Minnesota | W82-57 | 10-0 | 1.000 | #10 | BTN | Crisler Center · Ann Arbor, MI |
| 12 | Tue Jan 12 | vs9Wisconsin | W77-54 | 11-0 | 1.000 | #7 | ESPN | Crisler Center · Ann Arbor, MI |
| 13 | Sat Jan 16 | at23Minnesota | L57-75 | 11-1 | .917 | #7 | ESPN2 | Williams Arena · Minneapolis, MN |
| 14 | Tue Jan 19 | vsMaryland | W87-63 | 12-1 | .923 | #7 | FS1 | Crisler Center · Ann Arbor, MI |
| 15 | Fri Jan 22 | atPurdue | W70-53 | 13-1 | .929 | #7 | FS1 | Mackey Arena · West Lafayette, IN |
| 18 | Thu Feb 11 | vs6Illinois | PPD | 23-5 | .821 | #3 | | Crisler Center · Ann Arbor, MI |
| 19 | Sun Feb 14 | at21Wisconsin | W67-59 | 14-1 | .933 | #3 | CBS | Kohl Center · Madison, WI |
| 20 | Thu Feb 18 | vsRutgers | W71-64 | 15-1 | .938 | #3 | FS1 | Crisler Center · Ann Arbor, MI |
| 21 | Sun Feb 21 | at4Ohio State | W92-87 | 16-1 | .941 | #3 | CBS | Value City Arena · Columbus, OH |
| 22 | Thu Feb 25 | vs9Iowa | W79-57 | 17-1 | .944 | #3 | ESPN | Crisler Center · Ann Arbor, MI |
| 23 | Sat Feb 27 | atIndiana | W73-57 | 18-1 | .947 | #3 | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 24 | Tue Mar 2 | vs4Illinois | L53-76 | 18-2 | .900 | #2 | ESPN | Crisler Center · Ann Arbor, MI |
| 25 | Thu Mar 4 | vsMichigan St | W69-50 | 19-2 | .905 | #2 | ESPN | Crisler Center · Ann Arbor, MI |
| 26 | Sun Mar 7 | atMichigan St | L64-70 | 19-3 | .864 | #2 | CBS | Breslin Center · East Lansing, MI |
| 27 | Fri Mar 12 | vsMaryland | W79-66 | 20-3 | .870 | - | BTN | Lucas Oil Stadium · Indianapolis, IN |
| 28 | Sat Mar 13 | vsOhio State | L67-68 | 20-4 | .833 | - | CBS | Lucas Oil Stadium · Indianapolis, IN |
| 26 | Sat Mar 20 | vs16Texas So | W82-66 | 21-4 | .840 | #1 | CBS | Mackey Arena · West Lafayette, IN |
| 27 | Mon Mar 22 | vs8LSU | W86-78 | 22-4 | .846 | #1 | CBS | Lucas Oil Stadium · Indianapolis, IN |
| 28 | Sun Mar 28 | vs4Florida St | W76-58 | 23-4 | .852 | #1 | CBS | Crisler Center · Ann Arbor, MI |
| 29 | Tue Mar 30 | vs11UCLA | L49-51 | 23-5 | .821 | #1 | TBS | Lucas Oil Stadium · Indianapolis, IN |
