| 1 | Wed Nov 10 | vs Buffalo | W88-76 | 1-0 | 1.000 | #6 | BTN | Crisler Center · Ann Arbor, MI |
| 2 | Sat Nov 13 | vs Prairie View | W77-49 | 2-0 | 1.000 | - | BTN | Crisler Center · Ann Arbor, MI |
| 3 | Tue Nov 16 | vs Seton Hall | L65-67 | 2-1 | .667 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 4 | Sat Nov 20 | at UNLV | W74-61 | 3-1 | .750 | - | ESPN2 | Thomas & Mack Center · Las Vegas, NV |
| 5 | Sun Nov 21 | at Arizona | L62-80 | 3-2 | .600 | - | ESPN | McKale Center · Tucson, AZ |
| 6 | Wed Nov 24 | vs Tarleton | W65-54 | 4-2 | .667 | #20 | BTN | Crisler Center · Ann Arbor, MI |
| 7 | Wed Dec 1 | at UNC | L51-72 | 4-3 | .571 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 8 | Sat Dec 4 | vs SDSU | W72-58 | 5-3 | .625 | #24 | CBS | Crisler Center · Ann Arbor, MI |
| 9 | Tue Dec 7 | at Nebraska | W102-67 | 6-3 | .667 | - | ESPN2 | Pinnacle Bank Arena · Lincoln, NE |
| 10 | Sat Dec 11 | vs Minnesota | L65-75 | 6-4 | .600 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 11 | Sat Dec 18 | vs Southern Utah | W87-50 | 7-4 | .636 | - | BTN | Crisler Center · Ann Arbor, MI |
| 13 | Thu Dec 30 | at UCF | L71-85 | 7-5 | .583 | - | ESPN2 | Addition Financial Arena · Orlando, FL |
| 14 | Tue Jan 4 | at Rutgers | L67-75 | 7-6 | .538 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 15 | Sat Jan 8 | vs #10Michigan St | PPD | 19-15 | .559 | - | | Crisler Center · Ann Arbor, MI |
| 16 | Tue Jan 11 | vs #7Purdue | PPD | 19-15 | .559 | - | | Crisler Center · Ann Arbor, MI |
| 17 | Fri Jan 14 | at #25Illinois | L53-68 | 7-7 | .500 | - | FS1 | State Farm Center · Champaign, IL |
| 18 | Tue Jan 18 | vs Maryland | W83-64 | 8-7 | .533 | - | ESPN2 | Crisler Center · Ann Arbor, MI |
| 19 | Sun Jan 23 | at Indiana | W80-62 | 9-7 | .563 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 20 | Wed Jan 26 | vs Northwestern | W72-70 | 10-7 | .588 | - | BTN | Crisler Center · Ann Arbor, MI |
| 21 | Sat Jan 29 | at#10Michigan St | L67-83 | 10-8 | .556 | - | CBS | Breslin Center · East Lansing, MI |
| 22 | Tue Feb 1 | vsNebraska | W85-79 | 11-8 | .579 | - | BTN | Crisler Center · Ann Arbor, MI |
| 23 | Sat Feb 5 | at#4Purdue | L76-82 | 11-9 | .550 | - | FOX | Mackey Arena · West Lafayette, IN |
| 24 | Tue Feb 8 | at Penn State | W58-57 | 12-9 | .571 | - | ESPN2 | Bryce Jordan Center · University Park, PA |
| 25 | Thu Feb 10 | vs#3Purdue | W82-58 | 13-9 | .591 | - | ESPN | Crisler Center · Ann Arbor, MI |
| 26 | Sat Feb 12 | vs #16Ohio State | L57-68 | 13-10 | .565 | - | ESPN | Crisler Center · Ann Arbor, MI |
| 27 | Thu Feb 17 | at Iowa | W84-79 | 14-10 | .583 | - | ESPN | Carver-Hawkeye Arena · Iowa City, IA |
| 28 | Sun Feb 20 | at #15Wisconsin | L63-77 | 14-11 | .560 | - | CBS | Kohl Center · Madison, WI |
| 29 | Wed Feb 23 | vsRutgers | W71-62 | 15-11 | .577 | - | BTN | Crisler Center · Ann Arbor, MI |
| 30 | Sun Feb 27 | vs#15Illinois | L85-93 | 15-12 | .556 | - | CBS | Crisler Center · Ann Arbor, MI |
| 31 | Tue Mar 1 | vsMichigan St | W87-70 | 16-12 | .571 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 32 | Thu Mar 3 | vs#24Iowa | L71-82 | 16-13 | .552 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 33 | Sun Mar 6 | at#23Ohio State | W75-69 | 17-13 | .567 | - | FOX | Value City Arena · Columbus, OH |
| 34 | Thu Mar 10 | vsIndiana | L69-74 | 17-14 | .548 | - | BTN | Crisler Center · Ann Arbor, MI |
| 35 | Thu Mar 17 | at #6Colorado St | W75-63 | 18-14 | .563 | #11 | CBS | Moby Arena · Fort Collins, CO |
| 36 | Sat Mar 19 | at #3Tennessee | W76-68 | 19-14 | .576 | #11 | CBS | Thompson-Boling Arena · Knoxville, TN |
| 37 | Thu Mar 24 | at #2Villanova | L55-63 | 19-15 | .559 | #11 | TBS | Finneran Pavilion · Villanova, PA |
