| 1 | Tue Nov 7 | vs UNC Asheville | W99-74 | 1-0 | 1.000 | - | BTN | Crisler Center · Ann Arbor, MI |
| 2 | Fri Nov 10 | vsYoungstown St | W92-62 | 2-0 | 1.000 | - | BTN | Crisler Center · Ann Arbor, MI |
| 3 | Mon Nov 13 | atSt John's | W89-73 | 3-0 | 1.000 | - | FS1 | Carnesecca Arena · Queens, NY |
| 4 | Fri Nov 17 | vsLong Beach St | L86-94 | 3-1 | .750 | - | | Crisler Center · Ann Arbor, MI |
| 5 | Wed Nov 22 | vsMemphis | L67-71 | 3-2 | .600 | - | ESPN2 | Crisler Center · Ann Arbor, MI |
| 6 | Thu Nov 23 | vsStanford | W83-78 | 4-2 | .667 | - | ESPN2 | Crisler Center · Ann Arbor, MI |
| 7 | Fri Nov 24 | atTexas Tech | L57-73 | 4-3 | .571 | - | ESPNU | United Supermarkets Arena · Lubbock, TX |
| 8 | Sat Dec 2 | atOregon | L83-86 (OT) | 4-4 | .500 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 9 | Tue Dec 5 | vsIndiana | L75-78 | 4-5 | .444 | - | | Crisler Center · Ann Arbor, MI |
| 10 | Sun Dec 10 | atIowa | W90-80 | 5-5 | .500 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 11 | Sat Dec 16 | vsE Michigan | W83-66 | 6-5 | .545 | - | BTN | Crisler Center · Ann Arbor, MI |
| 12 | Tue Dec 19 | vsFlorida | L101-106 (2OT) | 6-6 | .500 | - | ESPN | Crisler Center · Ann Arbor, MI |
| 13 | Fri Dec 29 | vsMcNeese | L76-87 | 6-7 | .462 | - | BTN | Crisler Center · Ann Arbor, MI |
| 14 | Thu Jan 4 | vsMinnesota | L71-73 | 6-8 | .429 | - | | Crisler Center · Ann Arbor, MI |
| 15 | Sun Jan 7 | atPenn State | L73-79 | 6-9 | .400 | - | BTN | The Palestra · Philadelphia, PA |
| 16 | Thu Jan 11 | atMaryland | L57-64 | 6-10 | .375 | - | FS1 | XFINITY Center · College Park, MD |
| 17 | Mon Jan 15 | vsOhio State | W73-65 | 7-10 | .412 | - | FOX | Crisler Center · Ann Arbor, MI |
| 18 | Thu Jan 18 | vs14Illinois | L73-88 | 7-11 | .389 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 19 | Tue Jan 23 | at2Purdue | L67-99 | 7-12 | .368 | - | | Mackey Arena · West Lafayette, IN |
| 20 | Sat Jan 27 | vsIowa | L78-88 | 7-13 | .350 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 21 | Tue Jan 30 | atMichigan St | L62-81 | 7-14 | .333 | - | | Breslin Center · East Lansing, MI |
| 22 | Sat Feb 3 | vsRutgers | L59-69 | 7-15 | .318 | - | BTN | Crisler Center · Ann Arbor, MI |
| 23 | Wed Feb 7 | vs11Wisconsin | W72-68 | 8-15 | .348 | - | BTN | Crisler Center · Ann Arbor, MI |
| 24 | Sat Feb 10 | atNebraska | L59-79 | 8-16 | .333 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 25 | Tue Feb 13 | at14Illinois | L68-97 | 8-17 | .320 | - | | State Farm Center · Champaign, IL |
| 26 | Sat Feb 17 | vsMichigan St | L63-73 | 8-18 | .308 | - | FOX | Crisler Center · Ann Arbor, MI |
| 27 | Thu Feb 22 | atNorthwestern | L62-76 | 8-19 | .296 | - | FS1 | Welsh-Ryan Arena · Evanston, IL |
| 28 | Sun Feb 25 | vs3Purdue | L76-84 | 8-20 | .286 | - | CBS | Crisler Center · Ann Arbor, MI |
| 29 | Thu Feb 29 | atRutgers | L52-82 | 8-21 | .276 | - | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 30 | Sun Mar 3 | atOhio State | L61-84 | 8-22 | .267 | - | CBS | Value City Arena · Columbus, OH |
| 31 | Sun Mar 10 | vsNebraska | L70-85 | 8-23 | .258 | - | BTN | Crisler Center · Ann Arbor, MI |
| 32 | Wed Mar 13 | atPenn State | L57-66 | 8-24 | .250 | - | | Bryce Jordan Center · University Park, PA |
