| 1 | Mon Nov 7 | vs Purdue FW | W75-56 | 1-0 | 1.000 | #22 | BTN | Crisler Center · Ann Arbor, MI |
| 2 | Fri Nov 11 | vsE Michigan | W88-83 | 2-0 | 1.000 | #22 | ESPNU | Crisler Center · Ann Arbor, MI |
| 3 | Wed Nov 16 | atPitt | W91-60 | 3-0 | 1.000 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 4 | Thu Nov 17 | atArizona St | L62-87 | 3-1 | .750 | - | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 5 | Sun Nov 20 | vsOhio | W70-66 (OT) | 4-1 | .800 | #20 | BTN | Crisler Center · Ann Arbor, MI |
| 6 | Wed Nov 23 | vsJackson St | W78-68 | 5-1 | .833 | - | BTN | Crisler Center · Ann Arbor, MI |
| 7 | Tue Nov 29 | vsVirginia | L68-70 | 5-2 | .714 | - | ESPN | Crisler Center · Ann Arbor, MI |
| 8 | Sun Dec 4 | atKentucky | L69-73 | 5-3 | .625 | - | ABC | Rupp Arena · Lexington, KY |
| 9 | Thu Dec 8 | atMinnesota | W90-75 | 6-3 | .667 | - | BTN | Williams Arena · Minneapolis, MN |
| 10 | Sat Dec 17 | vsLipscomb | W83-75 | 7-3 | .700 | - | | Crisler Center · Ann Arbor, MI |
| 11 | Wed Dec 21 | atUNC | L76-80 | 7-4 | .636 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 12 | Thu Dec 29 | vsC Michigan | L61-63 | 7-5 | .583 | - | | Crisler Center · Ann Arbor, MI |
| 13 | Sun Jan 1 | vsMaryland | W81-46 | 8-5 | .615 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 14 | Wed Jan 4 | vsPenn State | W79-69 | 9-5 | .643 | - | BTN | Crisler Center · Ann Arbor, MI |
| 15 | Sat Jan 7 | atMichigan St | L53-59 | 9-6 | .600 | - | FOX | Breslin Center · East Lansing, MI |
| 16 | Thu Jan 12 | atIowa | L84-93 (OT) | 9-7 | .563 | - | ESPN2 | Carver-Hawkeye Arena · Iowa City, IA |
| 17 | Sun Jan 15 | vsNorthwestern | W85-78 | 10-7 | .588 | - | BTN | Crisler Center · Ann Arbor, MI |
| 18 | Thu Jan 19 | atMaryland | L58-64 | 10-8 | .556 | - | ESPN | XFINITY Center · College Park, MD |
| 19 | Sun Jan 22 | vsMinnesota | W60-56 | 11-8 | .579 | - | BTN | Crisler Center · Ann Arbor, MI |
| 20 | Thu Jan 26 | vs1Purdue | L70-75 | 11-9 | .550 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 21 | Sun Jan 29 | atPenn State | L61-83 | 11-10 | .524 | - | BTN | Bryce Jordan Center · University Park, PA |
| 22 | Thu Feb 2 | atNorthwestern | W68-51 | 12-10 | .545 | - | ESPN2 | Welsh-Ryan Arena · Evanston, IL |
| 23 | Sun Feb 5 | vsOhio State | W77-69 | 13-10 | .565 | - | CBS | Crisler Center · Ann Arbor, MI |
| 24 | Wed Feb 8 | vsNebraska | W93-72 | 14-10 | .583 | - | BTN | Crisler Center · Ann Arbor, MI |
| 25 | Sat Feb 11 | vs18Indiana | L61-62 | 14-11 | .560 | - | ESPN | Crisler Center · Ann Arbor, MI |
| 26 | Tue Feb 14 | atWisconsin | L59-64 | 14-12 | .538 | - | ESPN2 | Kohl Center · Madison, WI |
| 27 | Sat Feb 18 | vsMichigan St | W84-72 | 15-12 | .556 | - | FOX | Crisler Center · Ann Arbor, MI |
| 28 | Thu Feb 23 | atRutgers | W58-45 | 16-12 | .571 | - | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 29 | Sun Feb 26 | vsWisconsin | W87-79 (OT) | 17-12 | .586 | - | CBS | Crisler Center · Ann Arbor, MI |
| 30 | Thu Mar 2 | atIllinois | L87-91 (2OT) | 17-13 | .567 | - | ESPN | State Farm Center · Champaign, IL |
| 31 | Sun Mar 5 | at15Indiana | L73-75 (OT) | 17-14 | .548 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 32 | Thu Mar 9 | vsRutgers | L50-62 | 17-15 | .531 | - | BTN | Crisler Center · Ann Arbor, MI |
| 33 | Tue Mar 14 | vsToledo | W90-80 | 18-15 | .545 | - | ESPN2 | Crisler Center · Ann Arbor, MI |
| 34 | Sat Mar 18 | atVanderbilt | L65-66 | 18-16 | .529 | - | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
