| 1 | Tue Nov 4 | vs Robert Morris | W101-69 | 1-0 | 1.000 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 2 | Fri Nov 7 | vsW Illinois | W77-58 | 2-0 | 1.000 | - | B1G+ | Carver-Hawkeye Arena · Iowa City, IA |
| 3 | Fri Nov 14 | vsXavier | W81-62 | 3-0 | 1.000 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 4 | Tue Nov 18 | vsSE Missouri St | W99-70 | 4-0 | 1.000 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 5 | Thu Nov 20 | vsChicago St | W93-54 | 5-0 | 1.000 | - | B1G+ | Carver-Hawkeye Arena · Iowa City, IA |
| 6 | Tue Nov 25 | vsOle Miss | W74-69 | 6-0 | 1.000 | - | CBSSN | Carver-Hawkeye Arena · Iowa City, IA |
| 7 | Wed Nov 26 | atGrand Canyon | W59-46 | 7-0 | 1.000 | - | | GCU Arena · Phoenix, AZ |
| 8 | Tue Dec 2 | at7Michigan St | L52-71 | 7-1 | .875 | - | Peacock | Breslin Center · East Lansing, MI |
| 9 | Sat Dec 6 | vsMaryland | W83-64 | 8-1 | .889 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 10 | Thu Dec 11 | at4Iowa State | L62-66 | 8-2 | .800 | - | FS1 | James H. Hilton Coliseum · Ames, IA |
| 11 | Sun Dec 14 | vsW Michigan | W91-51 | 9-2 | .818 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 12 | Sat Dec 20 | vsBucknell | W94-39 | 10-2 | .833 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 13 | Mon Dec 29 | vsUMass Lowell | W90-62 | 11-2 | .846 | #25 | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 14 | Sat Jan 3 | vsUCLA | W74-61 | 12-2 | .857 | #25 | Peacock | Carver-Hawkeye Arena · Iowa City, IA |
| 15 | Tue Jan 6 | atMinnesota | L67-70 | 12-3 | .800 | #19 | BTN | Williams Arena · Minneapolis, MN |
| 16 | Sun Jan 11 | vs16Illinois | L69-75 | 12-4 | .750 | #19 | FOX | Carver-Hawkeye Arena · Iowa City, IA |
| 17 | Wed Jan 14 | at5Purdue | L72-79 | 12-5 | .706 | - | BTN | Mackey Arena · West Lafayette, IN |
| 18 | Sat Jan 17 | atIndiana | W74-57 | 13-5 | .722 | - | FOX | Simon Skjodt Assembly Hall · Bloomington, IN |
| 19 | Tue Jan 20 | vsRutgers | W68-62 | 14-5 | .737 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 20 | Wed Jan 28 | vsUSC | W73-72 | 15-5 | .750 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 21 | Sun Feb 1 | atOregon | W84-66 | 16-5 | .762 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 22 | Wed Feb 4 | atWashington | W84-74 | 17-5 | .773 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 23 | Sun Feb 8 | vsNorthwestern | W76-70 | 18-5 | .783 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 24 | Wed Feb 11 | atMaryland | L70-77 | 18-6 | .750 | - | FS1 | XFINITY Center · College Park, MD |
| 25 | Sat Feb 14 | vs13Purdue | L57-78 | 18-7 | .720 | - | FOX | Carver-Hawkeye Arena · Iowa City, IA |
| 26 | Tue Feb 17 | vs9Nebraska | W57-52 | 19-7 | .731 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 27 | Sun Feb 22 | at24Wisconsin | L71-84 | 19-8 | .704 | - | FS1 | Kohl Center · Madison, WI |
| 28 | Wed Feb 25 | vsOhio State | W74-57 | 20-8 | .714 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 29 | Sat Feb 28 | atPenn State | L69-71 | 20-9 | .690 | - | BTN | Bryce Jordan Center · University Park, PA |
