| 1 | Tue Nov 7 | vs North Dakota | W110-68 | 1-0 | 1.000 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 2 | Fri Nov 10 | vsAlabama St | W98-67 | 2-0 | 1.000 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 3 | Tue Nov 14 | at8Creighton | L84-92 | 2-1 | .667 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 4 | Fri Nov 17 | vsArkansas St | W88-74 | 3-1 | .750 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 5 | Thu Nov 23 | vsOklahoma | L67-79 | 3-2 | .600 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 6 | Fri Nov 24 | vsSeton Hall | W85-72 | 4-2 | .667 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 7 | Wed Nov 29 | vsNorth Florida | W103-78 | 5-2 | .714 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 8 | Mon Dec 4 | at4Purdue | L68-87 | 5-3 | .625 | - | BTN | Mackey Arena · West Lafayette, IN |
| 9 | Thu Dec 7 | atIowa State | L65-90 | 5-4 | .556 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 10 | Sun Dec 10 | vsMichigan | L80-90 | 5-5 | .500 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 11 | Sat Dec 16 | vsFAMU | W88-52 | 6-5 | .545 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 12 | Wed Dec 20 | vsUMBC | W103-81 | 7-5 | .583 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 13 | Fri Dec 29 | vsN Illinois | W103-74 | 8-5 | .615 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 14 | Tue Jan 2 | at21Wisconsin | L72-83 | 8-6 | .571 | - | BTN | Kohl Center · Madison, WI |
| 15 | Sat Jan 6 | vsRutgers | W86-77 | 9-6 | .600 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 16 | Fri Jan 12 | vsNebraska | W94-76 | 10-6 | .625 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 17 | Mon Jan 15 | atMinnesota | W86-77 | 11-6 | .647 | - | BTN | Williams Arena · Minneapolis, MN |
| 18 | Sat Jan 20 | vs2Purdue | L70-84 | 11-7 | .611 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 19 | Wed Jan 24 | vsMaryland | L67-69 | 11-8 | .579 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 20 | Sat Jan 27 | atMichigan | W88-78 | 12-8 | .600 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 21 | Tue Jan 30 | atIndiana | L68-74 | 12-9 | .571 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 22 | Fri Feb 2 | vsOhio State | W79-77 | 13-9 | .591 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 23 | Thu Feb 8 | atPenn State | L79-89 | 13-10 | .565 | - | BTN | Bryce Jordan Center · University Park, PA |
| 24 | Sun Feb 11 | vsMinnesota | W90-85 | 14-10 | .583 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 25 | Wed Feb 14 | atMaryland | L66-78 | 14-11 | .560 | - | BTN | XFINITY Center · College Park, MD |
| 26 | Sat Feb 17 | vs20Wisconsin | W88-86 (OT) | 15-11 | .577 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 27 | Tue Feb 20 | atMichigan St | W78-71 | 16-11 | .593 | - | | Breslin Center · East Lansing, MI |
| 28 | Sat Feb 24 | at12Illinois | L85-95 | 16-12 | .571 | - | BTN | State Farm Center · Champaign, IL |
| 29 | Tue Feb 27 | vsPenn State | W90-81 | 17-12 | .586 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 30 | Sat Mar 2 | atNorthwestern | W87-80 | 18-12 | .600 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 31 | Sun Mar 10 | vs12Illinois | L61-73 | 18-13 | .581 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 32 | Thu Mar 14 | vsOhio State | L78-90 | 18-14 | .563 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 33 | Tue Mar 19 | vsKansas St | W91-82 | 19-14 | .576 | - | ESPN | Carver-Hawkeye Arena · Iowa City, IA |
| 34 | Sun Mar 24 | atUtah | L82-91 | 19-15 | .559 | - | ESPN2 | Jon M. Huntsman Center · Salt Lake City, UT |
