| 1 | Fri Nov 8 | vs SIUE | W87-60 | 1-0 | 1.000 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 2 | Mon Nov 11 | vsDePaul | L78-93 | 1-1 | .500 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 3 | Fri Nov 15 | vsOral Roberts | W87-74 | 2-1 | .667 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 4 | Thu Nov 21 | vsNorth Florida | W83-68 | 3-1 | .750 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 5 | Sun Nov 24 | vsCal Poly | W85-59 | 4-1 | .800 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 6 | Thu Nov 28 | atTexas Tech | W72-61 | 5-1 | .833 | - | FS1 | Orleans Arena · Las Vegas, NV |
| 7 | Fri Nov 29 | vsSDSU | L73-83 | 5-2 | .714 | - | FS1 | Orleans Arena · Las Vegas, NV |
| 8 | Tue Dec 3 | atSyracuse | W68-54 | 6-2 | .750 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 9 | Fri Dec 6 | at4Michigan | L91-103 | 6-3 | .667 | - | FS1 | Crisler Center · Ann Arbor, MI |
| 10 | Mon Dec 9 | vsMinnesota | W72-52 | 7-3 | .700 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 11 | Thu Dec 12 | atIowa State | W84-68 | 8-3 | .727 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 12 | Sat Dec 21 | vsCincinnati | W77-70 | 9-3 | .750 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 13 | Sun Dec 29 | vsKennesaw St | W93-51 | 10-3 | .769 | #25 | ESPNU | Carver-Hawkeye Arena · Iowa City, IA |
| 14 | Sat Jan 4 | at21Penn State | L86-89 | 10-4 | .714 | #23 | BTN | The Palestra · Philadelphia, PA |
| 15 | Tue Jan 7 | atNebraska | L70-76 | 10-5 | .667 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 16 | Fri Jan 10 | vs12Maryland | W67-49 | 11-5 | .688 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 17 | Tue Jan 14 | atNorthwestern | W75-62 | 12-5 | .706 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 18 | Fri Jan 17 | vs19Michigan | W90-83 | 13-5 | .722 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 19 | Wed Jan 22 | vs24Rutgers | W85-80 | 14-5 | .737 | #19 | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 20 | Mon Jan 27 | vsWisconsin | W68-62 | 15-5 | .750 | #18 | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 21 | Thu Jan 30 | at15Maryland | L72-82 | 15-6 | .714 | #18 | BTN | XFINITY Center · College Park, MD |
| 22 | Sun Feb 2 | vs19Illinois | W72-65 | 16-6 | .727 | #18 | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 23 | Wed Feb 5 | atPurdue | L68-104 | 16-7 | .696 | #17 | BTN | Mackey Arena · West Lafayette, IN |
| 24 | Sat Feb 8 | vsNebraska | W96-72 | 17-7 | .708 | #17 | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 25 | Thu Feb 13 | atIndiana | L77-89 | 17-8 | .680 | #21 | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 26 | Sun Feb 16 | atMinnesota | W58-55 | 18-8 | .692 | #21 | FS1 | Williams Arena · Minneapolis, MN |
| 27 | Thu Feb 20 | vs25Ohio State | W85-76 | 19-8 | .704 | #20 | ESPN | Carver-Hawkeye Arena · Iowa City, IA |
| 28 | Tue Feb 25 | at24Michigan St | L70-78 | 19-9 | .679 | #18 | ESPN2 | Breslin Center · East Lansing, MI |
| 29 | Sat Feb 29 | vs16Penn State | W77-68 | 20-9 | .690 | #18 | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 30 | Tue Mar 3 | vsPurdue | L68-77 | 20-10 | .667 | #18 | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 31 | Sun Mar 8 | at23Illinois | L76-78 | 20-11 | .645 | #18 | BTN | State Farm Center · Champaign, IL |
