| 1 | Mon Nov 4 | vs AR-Pine Bluff | W109-54 | 1-0 | 1.000 | #20 | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 2 | Fri Nov 8 | vs Morehead St | W83-56 | 2-0 | 1.000 | #20 | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 3 | Fri Nov 15 | vs Nicholls | W86-49 | 3-0 | 1.000 | #17 | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 4 | Tue Nov 19 | at N Kentucky | W76-60 | 4-0 | 1.000 | #18 | ESPN+ | Truist Arena · Highland Heights, KY |
| 5 | Sat Nov 23 | at Georgia Tech | W81-58 | 5-0 | 1.000 | #18 | ESPN+ | McCamish Pavilion · Atlanta, GA |
| 6 | Wed Nov 27 | vs Alabama St | W77-59 | 6-0 | 1.000 | #16 | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 7 | Tue Dec 3 | at Villanova | L60-68 | 6-1 | .857 | #14 | FS1 | Finneran Pavilion · Villanova, PA |
| 8 | Sun Dec 8 | vs Howard | W84-67 | 7-1 | .875 | #14 | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 9 | Sat Dec 14 | vs Xavier | W68-65 | 8-1 | .889 | #22 | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 10 | Fri Dec 20 | at #22Dayton | W66-59 | 9-1 | .900 | #19 | ESPNU | UD Arena · Dayton, OH |
| 11 | Sun Dec 22 | vs Grambling | W84-49 | 10-1 | .909 | #19 | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 12 | Mon Dec 30 | at Kansas St | L67-70 | 10-2 | .833 | #16 | CBS | Bramlage Coliseum · Manhattan, KS |
| 13 | Sat Jan 4 | vs Arizona | L67-72 | 10-3 | .769 | #16 | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 14 | Tue Jan 7 | at Baylor | L48-68 | 10-4 | .714 | - | ESPN+ | Ferrell Center · Waco, TX |
| 15 | Sat Jan 11 | vs #11Kansas | L40-54 | 10-5 | .667 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 16 | Wed Jan 15 | at Colorado | W68-62 | 11-5 | .688 | - | ESPN+ | CU Events Center · Boulder, CO |
| 17 | Sat Jan 18 | vs Arizona St | W67-60 | 12-5 | .706 | - | CBS | Fifth Third Arena · Cincinnati, OH |
| 18 | Tue Jan 21 | vs Texas Tech | L71-81 | 12-6 | .667 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 19 | Sat Jan 25 | at BYU | L52-80 | 12-7 | .632 | - | ESPN2 | Marriott Center · Provo, UT |
| 20 | Tue Jan 28 | at Utah | L66-69 | 12-8 | .600 | - | CBS | Jon M. Huntsman Center · Salt Lake City, UT |
| 21 | Sun Feb 2 | vs West Virginia | L50-63 | 12-9 | .571 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 22 | Wed Feb 5 | at UCF | W93-83 | 13-9 | .591 | - | CBS | Addition Financial Arena · Orlando, FL |
| 23 | Sat Feb 8 | vsBYU | W84-66 | 14-9 | .609 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 24 | Tue Feb 11 | vsUtah | W85-75 | 15-9 | .625 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 25 | Sat Feb 15 | at #10Iowa State | L70-81 | 15-10 | .600 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 26 | Wed Feb 19 | atWest Virginia | L59-62 | 15-11 | .577 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
TCU
#5Houston
Oklahoma St