| 1 | Tue Nov 9 | vs Evansville | W65-43 | 1-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 2 | Sat Nov 13 | vs Georgia | W73-68 | 2-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 3 | Tue Nov 16 | vs Alabama A&M | W89-66 | 3-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 4 | Thu Nov 18 | vs Presbyterian | W79-45 | 4-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 5 | Mon Nov 22 | vs Illinois | W71-51 | 5-0 | 1.000 | - | ESPNEWS | Fifth Third Arena · Cincinnati, OH |
| 6 | Tue Nov 23 | at Arkansas | L67-73 | 5-1 | .833 | - | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 7 | Sat Nov 27 | vs Monmouth | L59-61 | 5-2 | .714 | - | | Fifth Third Arena · Cincinnati, OH |
| 8 | Wed Dec 1 | at Miami OH | W59-58 | 6-2 | .750 | - | | Millett Hall · Oxford, OH |
| 9 | Sun Dec 5 | vs Bryant | W73-58 | 7-2 | .778 | - | | Fifth Third Arena · Cincinnati, OH |
| 10 | Sat Dec 11 | at Xavier | L63-83 | 7-3 | .700 | - | FS1 | Cintas Center · Cincinnati, OH |
| 11 | Tue Dec 14 | vs FAMU | W77-50 | 8-3 | .727 | - | | Fifth Third Arena · Cincinnati, OH |
| 12 | Sat Dec 18 | vs TBD | W71-57 | 9-3 | .750 | - | | Fifth Third Arena · Cincinnati, OH |
| 13 | Tue Dec 21 | vs Tennessee Tech | W76-67 | 10-3 | .769 | - | | Fifth Third Arena · Cincinnati, OH |
| 14 | Tue Dec 28 | at #12Houston | PPD | 10-3 | .769 | - | | Fertitta Center · Houston, TX |
| 15 | Sat Jan 1 | vs Tulane | L60-68 | 10-4 | .714 | - | | Fifth Third Arena · Cincinnati, OH |
| 16 | Thu Jan 6 | vs SMU | W77-60 | 11-4 | .733 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 17 | Sun Jan 9 | at Memphis | L80-87 | 11-5 | .688 | - | ABC | FedExForum · Memphis, TN |
| 18 | Wed Jan 12 | vs E Carolina | W79-71 | 12-5 | .706 | - | | Fifth Third Arena · Cincinnati, OH |
| 19 | Sun Jan 16 | at Wichita St | W61-57 | 13-5 | .722 | - | ESPN | Charles Koch Arena · Wichita, KS |
| 20 | Thu Jan 20 | vs Tulsa | W90-69 | 14-5 | .737 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 21 | Tue Jan 25 | at Temple | L58-61 | 14-6 | .700 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 22 | Sun Jan 30 | atE Carolina | W60-59 | 15-6 | .714 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 23 | Thu Feb 3 | vsMemphis | PPD | 18-15 | .545 | - | | Fifth Third Arena · Cincinnati, OH |
| 24 | Sun Feb 6 | vs#6Houston | L58-80 | 15-7 | .682 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 25 | Wed Feb 9 | at South Florida | W70-59 | 16-7 | .696 | - | | Yuengling Center · Tampa, FL |
| 26 | Sat Feb 12 | atTulsa | L77-83 | 16-8 | .667 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 27 | Tue Feb 15 | vsMemphis | L74-81 | 16-9 | .640 | - | | Fifth Third Arena · Cincinnati, OH |
| 28 | Thu Feb 17 | vsWichita St | W85-76 | 17-9 | .654 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 29 | Sun Feb 20 | vsTemple | L71-75 | 17-10 | .630 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 30 | Wed Feb 23 | at UCF | L61-75 | 17-11 | .607 | - | ESPNU | Addition Financial Arena · Orlando, FL |
| 31 | Sat Feb 26 | vsSouth Florida | L54-56 | 17-12 | .586 | - | | Fifth Third Arena · Cincinnati, OH |
| 32 | Tue Mar 1 | at#14Houston | L53-71 | 17-13 | .567 | - | ESPNU | Fertitta Center · Houston, TX |
| 33 | Thu Mar 3 | atSMU | L71-76 | 17-14 | .548 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 34 | Thu Mar 10 | vsE Carolina | W74-63 | 18-14 | .563 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 35 | Fri Mar 11 | atHouston | L56-69 | 18-15 | .545 | - | ESPN2 | Fertitta Center · Houston, TX |
