| 1 | Mon Nov 6 | vs UIC | W69-58 | 1-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 2 | Fri Nov 10 | vs Detroit Mercy | W93-61 | 2-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 3 | Sun Nov 12 | vs E Washington | W85-73 | 3-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 4 | Sun Nov 19 | vs N Kentucky | W90-66 | 4-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 5 | Wed Nov 22 | vs Georgia Tech | W89-54 | 5-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 6 | Tue Nov 28 | at Howard | W86-81 (OT) | 6-0 | 1.000 | - | | Burr Gymnasium · Washington, D.C. |
| 7 | Sun Dec 3 | vs FGCU | W99-62 | 7-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 8 | Sat Dec 9 | at Xavier | L79-84 | 7-1 | .875 | - | FS1 | Cintas Center · Cincinnati, OH |
| 9 | Tue Dec 12 | vs Bryant | W85-53 | 8-1 | .889 | - | | Fifth Third Arena · Cincinnati, OH |
| 10 | Sat Dec 16 | vs Dayton | L68-82 | 8-2 | .800 | - | | Fifth Third Arena · Cincinnati, OH |
| 11 | Tue Dec 19 | vs Merrimack | W65-49 | 9-2 | .818 | - | | Fifth Third Arena · Cincinnati, OH |
| 12 | Fri Dec 22 | vs Stetson | W83-75 | 10-2 | .833 | - | | Fifth Third Arena · Cincinnati, OH |
| 13 | Fri Dec 29 | vs Evansville | W76-58 | 11-2 | .846 | - | | Fifth Third Arena · Cincinnati, OH |
| 14 | Sat Jan 6 | at #12BYU | W71-60 | 12-2 | .857 | - | ESPN2 | Marriott Center · Provo, UT |
| 15 | Tue Jan 9 | vs #25Texas | L73-74 | 12-3 | .800 | - | | Fifth Third Arena · Cincinnati, OH |
| 16 | Sat Jan 13 | at #14Baylor | L59-62 | 12-4 | .750 | - | ESPN | Ferrell Center · Waco, TX |
| 17 | Tue Jan 16 | vs #19TCU | W81-77 (OT) | 13-4 | .765 | - | | Fifth Third Arena · Cincinnati, OH |
| 18 | Sat Jan 20 | vs #15Oklahoma | L65-69 | 13-5 | .722 | - | | Fifth Third Arena · Cincinnati, OH |
| 19 | Mon Jan 22 | at #7Kansas | L69-74 | 13-6 | .684 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 20 | Sat Jan 27 | vs UCF | W68-57 | 14-6 | .700 | - | | Fifth Third Arena · Cincinnati, OH |
| 21 | Wed Jan 31 | at West Virginia | L65-69 | 14-7 | .667 | - | | WVU Coliseum · Morgantown, WV |
| 22 | Sat Feb 3 | at #15Texas Tech | W75-72 | 15-7 | .682 | - | | United Supermarkets Arena · Lubbock, TX |
| 23 | Sat Feb 10 | vs #5Houston | L62-67 | 15-8 | .652 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 24 | Tue Feb 13 | vs #10Iowa State | L59-68 | 15-9 | .625 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 25 | Sat Feb 17 | atUCF | W76-74 | 16-9 | .640 | - | | Addition Financial Arena · Orlando, FL |
| 26 | Wed Feb 21 | vs Oklahoma St | L76-80 | 16-10 | .615 | - | | Fifth Third Arena · Cincinnati, OH |
| 27 | Sat Feb 24 | atTCU | L57-75 | 16-11 | .593 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 28 | Tue Feb 27 | at#1Houston | L59-67 | 16-12 | .571 | - | ESPN2 | Fertitta Center · Houston, TX |
| 29 | Sat Mar 2 | vs Kansas St | W74-72 | 17-12 | .586 | - | | Fifth Third Arena · Cincinnati, OH |
| 30 | Tue Mar 5 | atOklahoma | L71-74 (OT) | 17-13 | .567 | - | | Lloyd Noble Center · Norman, OK |
| 31 | Sat Mar 9 | vsWest Virginia | W92-56 | 18-13 | .581 | - | | Fifth Third Arena · Cincinnati, OH |
| 32 | Tue Mar 12 | vsWest Virginia | W90-85 | 19-13 | .594 | - | | Fifth Third Arena · Cincinnati, OH |
| 33 | Wed Mar 13 | at#16Kansas | W72-52 | 20-13 | .606 | - | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 34 | Thu Mar 14 | at#14Baylor | L56-68 | 20-14 | .588 | - | ESPN2 | Ferrell Center · Waco, TX |
| 35 | Wed Mar 20 | vs San Francisco | W73-72 (OT) | 21-14 | .600 | - | | Fifth Third Arena · Cincinnati, OH |
| 36 | Sat Mar 23 | vs Bradley | W74-57 | 22-14 | .611 | - | | Fifth Third Arena · Cincinnati, OH |
| 37 | Tue Mar 26 | at Indiana St | L81-85 | 22-15 | .595 | - | ESPN | Hulman Center · Terre Haute, IN |
