| 1 | Mon Nov 3 | vs W Carolina | W94-63 | 1-0 | 1.000 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 2 | Fri Nov 7 | vsGeorgia St | W74-64 | 2-0 | 1.000 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 3 | Tue Nov 11 | vsDayton | W74-62 | 3-0 | 1.000 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 4 | Sun Nov 16 | vsMount St Mary | W72-55 | 4-0 | 1.000 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 5 | Fri Nov 21 | vs6Louisville | L64-74 | 4-1 | .800 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 6 | Mon Nov 24 | vsNJIT | W94-67 | 5-1 | .833 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 7 | Wed Nov 26 | vsE Michigan | L56-64 | 5-2 | .714 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 8 | Mon Dec 1 | vsTarleton | W76-58 | 6-2 | .750 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 9 | Fri Dec 5 | atXavier | L74-79 | 6-3 | .667 | - | TNT | Cintas Center · Cincinnati, OH |
| 10 | Sat Dec 13 | atGeorgia | L65-84 | 6-4 | .600 | - | ESPNU | State Farm Arena · Atlanta, GA |
| 11 | Wed Dec 17 | vsAlabama St | W88-51 | 7-4 | .636 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 12 | Sun Dec 21 | atClemson | L65-68 | 7-5 | .583 | - | ESPN | Littlejohn Coliseum · Clemson, SC |
| 13 | Mon Dec 29 | vsLipscomb | W89-62 | 8-5 | .615 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 14 | Sat Jan 3 | vs8Houston | L60-67 | 8-6 | .571 | - | FOX | Fifth Third Arena · Cincinnati, OH |
| 15 | Tue Jan 6 | atWest Virginia | L60-62 | 8-7 | .533 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 16 | Sun Jan 11 | at25UCF | L72-73 | 8-8 | .500 | - | ESPN2 | Addition Financial Arena · Orlando, FL |
| 17 | Wed Jan 14 | vsColorado | W77-68 | 9-8 | .529 | - | Peacock | Fifth Third Arena · Cincinnati, OH |
| 18 | Sat Jan 17 | vs2Iowa State | W79-70 | 10-8 | .556 | - | Peacock | Fifth Third Arena · Cincinnati, OH |
| 19 | Wed Jan 21 | at1Arizona | L51-77 | 10-9 | .526 | - | FS1 | McKale Center · Tucson, AZ |
| 20 | Sat Jan 24 | atArizona St | L68-82 | 10-10 | .500 | - | CBSSN | Desert Financial Arena · Tempe, AZ |
| 21 | Wed Jan 28 | vsBaylor | W67-57 | 11-10 | .524 | - | FS1 | Fifth Third Arena · Cincinnati, OH |
| 22 | Sat Jan 31 | at10Houston | L54-76 | 11-11 | .500 | - | FOX | Fertitta Center · Houston, TX |
| 23 | Thu Feb 5 | vsWest Virginia | L54-59 | 11-12 | .478 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 24 | Sun Feb 8 | vsUCF | W92-72 | 12-12 | .500 | - | CBSSN | Fifth Third Arena · Cincinnati, OH |
| 25 | Wed Feb 11 | atKansas St | W91-62 | 13-12 | .520 | - | CBSSN | Bramlage Coliseum · Manhattan, KS |
| 26 | Sun Feb 15 | vsUtah | W69-65 | 14-12 | .538 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 27 | Sat Feb 21 | at8Kansas | W84-68 | 15-12 | .556 | - | CBS | Allen Fieldhouse · Lawrence, KS |
| 28 | Tue Feb 24 | at16Texas Tech | L68-80 | 15-13 | .536 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 29 | Sat Feb 28 | vsOklahoma St | W91-68 | 16-13 | .552 | - | CBSSN | Fifth Third Arena · Cincinnati, OH |
