| 1 | Mon Nov 3 | vs W Carolina | 7:00 PM | 8-22 | .267 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 2 | Fri Nov 7 | vsGeorgia St | 7:00 PM | 14-19 | .424 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 3 | Tue Nov 11 | vsDayton | 7:00 PM | 23-11 | .676 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 4 | Sun Nov 16 | vsMount St Mary | 6:00 PM | 23-13 | .639 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 5 | Fri Nov 21 | vs#11Louisville | 6:30 PM | 27-8 | .771 | - | | Fifth Third Arena · Cincinnati, OH |
| 6 | Mon Nov 24 | vsNJIT | 7:00 PM | 6-25 | .194 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 7 | Wed Nov 26 | vsE Michigan | 7:00 PM | 16-16 | .500 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 8 | Mon Dec 1 | vsTarleton | 7:00 PM | 12-20 | .375 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 9 | Fri Dec 5 | atXavier | 7:30 PM | 22-12 | .647 | - | | Cintas Center · Cincinnati, OH |
| 10 | Sat Dec 13 | vsGeorgia | 2:00 PM | 20-13 | .606 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 11 | Wed Dec 17 | vsAlabama St | 7:00 PM | 20-16 | .556 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 12 | Sun Dec 21 | vsClemson | 3:00 PM | 27-7 | .794 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 13 | Mon Dec 29 | vsLipscomb | 7:00 PM | 25-10 | .714 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 14 | Sat Jan 3 | vs#2Houston | 2:00 PM | 35-5 | .875 | - | FOX | Fifth Third Arena · Cincinnati, OH |
| 15 | Tue Jan 6 | atWest Virginia | 7:00 PM | 19-13 | .594 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 16 | Sun Jan 11 | atUCF | 5:00 PM | 20-17 | .541 | - | ESPN2 | Addition Financial Arena · Orlando, FL |
| 17 | Wed Jan 14 | vsColorado | 7:00 PM | 14-21 | .400 | - | Peacock | Fifth Third Arena · Cincinnati, OH |
| 18 | Sat Jan 17 | vs#16Iowa State | 2:00 PM | 25-10 | .714 | - | Peacock | Fifth Third Arena · Cincinnati, OH |
| 19 | Wed Jan 21 | at#13Arizona | 9:00 PM | 24-13 | .649 | - | FS1 | McKale Center · Tucson, AZ |
| 20 | Sat Jan 24 | atArizona St | 10:00 PM | 13-20 | .394 | - | CBS | Desert Financial Arena · Tempe, AZ |
| 21 | Wed Jan 28 | vsBaylor | 6:30 PM | 20-15 | .571 | - | FS1 | Fifth Third Arena · Cincinnati, OH |
| 22 | Sat Jan 31 | at#2Houston | 12:00 PM | 35-5 | .875 | - | FOX | Fertitta Center · Houston, TX |
| 23 | Thu Feb 5 | vsWest Virginia | 7:00 PM | 19-13 | .594 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 24 | Sun Feb 8 | vsUCF | 2:00 PM | 20-17 | .541 | - | CBS | Fifth Third Arena · Cincinnati, OH |
| 25 | Wed Feb 11 | atKansas St | TBD | 16-17 | .485 | - | CBS | Bramlage Coliseum · Manhattan, KS |
| 26 | Sun Feb 15 | vsUtah | 12:00 PM | 16-17 | .485 | - | | Fifth Third Arena · Cincinnati, OH |
| 27 | Sat Feb 21 | at#19Kansas | 1:00 PM | 21-13 | .618 | - | CBS | Allen Fieldhouse · Lawrence, KS |
| 28 | Tue Feb 24 | at#10Texas Tech | 7:00 PM | 28-9 | .757 | - | | United Supermarkets Arena · Lubbock, TX |
| 29 | Sat Feb 28 | vsOklahoma St | 2:00 PM | 17-18 | .486 | - | CBS | Fifth Third Arena · Cincinnati, OH |
| 30 | Tue Mar 3 | vs#8BYU | 7:00 PM | 26-10 | .722 | - | | Fifth Third Arena · Cincinnati, OH |
| 31 | Sat Mar 7 | atTCU | 2:00 PM | 16-16 | .500 | - | TNT | Ed and Rae Schollmaier Arena · Fort Worth, TX |
