| 1 | Mon Nov 7 | vs TBD | W98-55 | 1-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 2 | Thu Nov 10 | vs Cleveland St | W69-58 | 2-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 3 | Sun Nov 13 | vs E Kentucky | W87-69 | 3-0 | 1.000 | - | | Fifth Third Arena · Cincinnati, OH |
| 4 | Wed Nov 16 | at N Kentucky | L51-64 | 3-1 | .750 | - | | Truist Arena · Highland Heights, KY |
| 5 | Mon Nov 21 | at Arizona | L93-101 | 3-2 | .600 | - | ESPN2 | McKale Center · Tucson, AZ |
| 6 | Tue Nov 22 | vs Ohio State | L53-81 | 3-3 | .500 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 7 | Wed Nov 23 | vs Louisville | W81-62 | 4-3 | .571 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 8 | Wed Nov 30 | vs NJIT | W86-60 | 5-3 | .625 | - | | Fifth Third Arena · Cincinnati, OH |
| 9 | Sun Dec 4 | vs Bryant | W97-71 | 6-3 | .667 | - | | Fifth Third Arena · Cincinnati, OH |
| 10 | Sat Dec 10 | vs Xavier | L77-80 | 6-4 | .600 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 11 | Wed Dec 14 | vs Miami OH | W103-76 | 7-4 | .636 | - | | Fifth Third Arena · Cincinnati, OH |
| 12 | Sat Dec 17 | vs La Salle | W78-60 | 8-4 | .667 | - | | Fifth Third Arena · Cincinnati, OH |
| 13 | Wed Dec 21 | vs Detroit Mercy | W72-54 | 9-4 | .692 | - | | Fifth Third Arena · Cincinnati, OH |
| 14 | Thu Dec 29 | vs Tulane | W88-77 | 10-4 | .714 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 15 | Sun Jan 1 | at Temple | L61-70 | 10-5 | .667 | - | ESPN | Liacouras Center · Philadelphia, PA |
| 16 | Thu Jan 5 | at Wichita St | W70-61 | 11-5 | .688 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 17 | Sun Jan 8 | vs #2Houston | L59-72 | 11-6 | .647 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 18 | Wed Jan 11 | vs E Carolina | W83-55 | 12-6 | .667 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 19 | Sat Jan 14 | at SMU | W54-52 | 13-6 | .684 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 20 | Wed Jan 18 | at South Florida | W85-69 | 14-6 | .700 | - | | Yuengling Center · Tampa, FL |
| 21 | Sun Jan 22 | vs Memphis | L68-75 | 14-7 | .667 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 22 | Sat Jan 28 | at#3Houston | L69-75 | 14-8 | .636 | - | CBS | Fertitta Center · Houston, TX |
| 23 | Wed Feb 1 | vs Tulsa | W81-55 | 15-8 | .652 | - | | Fifth Third Arena · Cincinnati, OH |
| 24 | Sat Feb 4 | vs UCF | W73-64 | 16-8 | .667 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 25 | Tue Feb 7 | atTulane | L94-101 (OT) | 16-9 | .640 | - | | Devlin Fieldhouse · New Orleans, LA |
| 26 | Sat Feb 11 | vsSouth Florida | W84-65 | 17-9 | .654 | - | | Fifth Third Arena · Cincinnati, OH |
| 27 | Wed Feb 15 | atE Carolina | L71-75 | 17-10 | .630 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 28 | Sun Feb 19 | atUCF | W73-71 | 18-10 | .643 | - | ESPNU | Addition Financial Arena · Orlando, FL |
| 29 | Wed Feb 22 | vsTemple | W88-83 (OT) | 19-10 | .655 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 30 | Sun Feb 26 | atMemphis | L73-76 | 19-11 | .633 | - | ESPN2 | FedExForum · Memphis, TN |
| 31 | Sun Mar 5 | vsSMU | W97-74 | 20-11 | .645 | - | | Fifth Third Arena · Cincinnati, OH |
| 32 | Fri Mar 10 | vsTemple | W84-54 | 21-11 | .656 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 33 | Sat Mar 11 | atHouston | L48-69 | 21-12 | .636 | - | ESPN2 | Fertitta Center · Houston, TX |
| 34 | Wed Mar 15 | vs Virginia Tech | W81-72 | 22-12 | .647 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 35 | Sat Mar 18 | at Hofstra | W79-65 | 23-12 | .657 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 36 | Wed Mar 22 | at Utah Valley | L68-74 | 23-13 | .639 | - | ESPN2 | UCCU Center · Orem, UT |
