| 1 | Mon Nov 4 | vs Missouri | W83-75 | 1-0 | 1.000 | - | ESPN+ | FedExForum · Memphis, TN |
| 2 | Sat Nov 9 | at UNLV | W80-74 | 2-0 | 1.000 | - | | Thomas & Mack Center · Las Vegas, NV |
| 3 | Fri Nov 15 | vs Ohio | W94-70 | 3-0 | 1.000 | - | ESPN+ | FedExForum · Memphis, TN |
| 4 | Thu Nov 21 | at San Francisco | W68-64 | 4-0 | 1.000 | - | ESPNU | War Memorial at the Sobrato Center · San Francisco, CA |
| 5 | Mon Nov 25 | at #2UConn | W99-97 (OT) | 5-0 | 1.000 | - | ESPN2 | Gampel Pavilion · Storrs, CT |
| 6 | Tue Nov 26 | at Michigan St | W71-63 | 6-0 | 1.000 | - | ESPN | Breslin Center · East Lansing, MI |
| 7 | Wed Nov 27 | at #4Auburn | L76-90 | 6-1 | .857 | - | ESPN | Neville Arena · Auburn, AL |
| 8 | Wed Dec 4 | vs Louisiana Tech | W81-71 | 7-1 | .875 | #16 | ESPN+ | FedExForum · Memphis, TN |
| 9 | Sun Dec 8 | vs Arkansas St | L72-85 | 7-2 | .778 | #16 | ESPNU | FedExForum · Memphis, TN |
| 10 | Sat Dec 14 | at #16Clemson | W87-82 (OT) | 8-2 | .800 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 11 | Wed Dec 18 | at Virginia | W64-62 | 9-2 | .818 | #21 | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 12 | Sat Dec 21 | vs Mississippi St | L66-79 | 9-3 | .750 | #21 | CBS | FedExForum · Memphis, TN |
| 13 | Sat Dec 28 | vs #16Ole Miss | W87-70 | 10-3 | .769 | - | ESPN2 | FedExForum · Memphis, TN |
| 14 | Thu Jan 2 | at FAU | W90-62 | 11-3 | .786 | #21 | ESPN2 | FAU Arena · Boca Raton, FL |
| 15 | Sun Jan 5 | vs North Texas | W68-64 | 12-3 | .800 | #21 | ESPN | FedExForum · Memphis, TN |
| 16 | Sat Jan 11 | vs E Carolina | W74-70 | 13-3 | .813 | #19 | ESPN+ | FedExForum · Memphis, TN |
| 17 | Thu Jan 16 | at Temple | L81-88 | 13-4 | .765 | #18 | ESPN2 | Liacouras Center · Philadelphia, PA |
| 18 | Sun Jan 19 | at Charlotte | W77-68 | 14-4 | .778 | #18 | ESPN2 | Dale F. Halton Arena · Charlotte, NC |
| 19 | Thu Jan 23 | vs Wichita St | W61-53 | 15-4 | .789 | #24 | ESPN2 | FedExForum · Memphis, TN |
| 20 | Sun Jan 26 | vs UAB | W100-77 | 16-4 | .800 | #24 | ESPN2 | FedExForum · Memphis, TN |
| 21 | Thu Jan 30 | at Tulane | W68-56 | 17-4 | .810 | #19 | ESPN2 | Devlin Fieldhouse · New Orleans, LA |
| 22 | Sun Feb 2 | at Rice | W86-83 | 18-4 | .818 | #19 | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 23 | Wed Feb 5 | vs Tulsa | W83-71 | 19-4 | .826 | #17 | ESPN+ | FedExForum · Memphis, TN |
| 24 | Sun Feb 9 | vsTemple | W90-82 | 20-4 | .833 | #17 | ESPN2 | FedExForum · Memphis, TN |
| 25 | Thu Feb 13 | at South Florida | W80-65 | 21-4 | .840 | #14 | ESPN2 | Yuengling Center · Tampa, FL |
| 26 | Sun Feb 16 | atWichita St | L79-84 (OT) | 21-5 | .808 | #14 | ESPN | Charles Koch Arena · Wichita, KS |
UTSA