| 1 | Mon Nov 7 | at Vanderbilt | W76-67 | 1-0 | 1.000 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 2 | Tue Nov 15 | atSaint Louis | L84-90 | 1-1 | .500 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 3 | Sun Nov 20 | vsVCU | W62-47 | 2-1 | .667 | - | | FedExForum · Memphis, TN |
| 4 | Thu Nov 24 | atSeton Hall | L69-70 | 2-2 | .500 | - | ESPNEWS | Prudential Center · Newark, NJ |
| 5 | Fri Nov 25 | vsNebraska | W73-61 | 3-2 | .600 | - | ESPNEWS | FedExForum · Memphis, TN |
| 6 | Sun Nov 27 | vsStanford | W56-48 | 4-2 | .667 | - | ESPNU | FedExForum · Memphis, TN |
| 7 | Wed Nov 30 | vsNorth Alabama | W87-68 | 5-2 | .714 | - | | FedExForum · Memphis, TN |
| 8 | Sat Dec 3 | vsOle Miss | W68-57 | 6-2 | .750 | - | ESPN2 | FedExForum · Memphis, TN |
| 9 | Tue Dec 6 | vsLittle Rock | W87-71 | 7-2 | .778 | - | | FedExForum · Memphis, TN |
| 10 | Sat Dec 10 | vsAuburn | W82-73 | 8-2 | .800 | - | ESPN2 | FedExForum · Memphis, TN |
| 11 | Tue Dec 13 | at#4Alabama | L88-91 | 8-3 | .727 | - | ESPN2 | Coleman Coliseum · Tuscaloosa, AL |
| 12 | Sat Dec 17 | vsTexas A&M | W83-79 | 9-3 | .750 | - | ESPNU | FedExForum · Memphis, TN |
| 13 | Wed Dec 21 | vsAlabama St | W83-61 | 10-3 | .769 | - | | FedExForum · Memphis, TN |
| 14 | Thu Dec 29 | vsSouth Florida | W93-86 | 11-3 | .786 | - | | FedExForum · Memphis, TN |
| 15 | Sun Jan 1 | atTulane | L89-96 | 11-4 | .733 | - | ESPN | Devlin Fieldhouse · New Orleans, LA |
| 16 | Sat Jan 7 | vsE Carolina | W69-59 | 12-4 | .750 | - | | FedExForum · Memphis, TN |
| 17 | Wed Jan 11 | atUCF | L104-107 (2OT) | 12-5 | .706 | - | | Addition Financial Arena · Orlando, FL |
| 18 | Sun Jan 15 | atTemple | W61-59 | 13-5 | .722 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 19 | Thu Jan 19 | vsWichita St | W88-78 | 14-5 | .737 | - | ESPNU | FedExForum · Memphis, TN |
| 20 | Sun Jan 22 | atCincinnati | W75-68 | 15-5 | .750 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 21 | Thu Jan 26 | vsSMU | W99-84 | 16-5 | .762 | - | ESPN2 | FedExForum · Memphis, TN |
| 22 | Sun Jan 29 | atTulsa | W80-68 | 17-5 | .773 | - | ESPN2 | Donald W. Reynolds Center · Tulsa, OK |
| 23 | Sat Feb 4 | vsTulane | L89-90 (OT) | 17-6 | .739 | - | ESPNU | FedExForum · Memphis, TN |
| 24 | Wed Feb 8 | atSouth Florida | W99-81 | 18-6 | .750 | - | | Yuengling Center · Tampa, FL |
| 25 | Sun Feb 12 | vsTemple | W86-77 | 19-6 | .760 | - | ESPN2 | FedExForum · Memphis, TN |
| 26 | Thu Feb 16 | vsUCF | W64-63 | 20-6 | .769 | - | | FedExForum · Memphis, TN |
| 27 | Sun Feb 19 | at#2Houston | L64-72 | 20-7 | .741 | - | ESPN | Fertitta Center · Houston, TX |
| 28 | Thu Feb 23 | atWichita St | W83-78 | 21-7 | .750 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 29 | Sun Feb 26 | vsCincinnati | W76-73 | 22-7 | .759 | - | ESPN2 | FedExForum · Memphis, TN |
| 30 | Thu Mar 2 | atSMU | W81-62 | 23-7 | .767 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 31 | Sun Mar 5 | vs#1Houston | L65-67 | 23-8 | .742 | - | CBS | FedExForum · Memphis, TN |
| 32 | Fri Mar 10 | vsUCF | W81-76 | 24-8 | .750 | - | ESPNU | FedExForum · Memphis, TN |
| 33 | Sat Mar 11 | vsTulane | W94-54 | 25-8 | .758 | - | ESPN2 | FedExForum · Memphis, TN |
| 34 | Sun Mar 12 | atHouston | W75-65 | 26-8 | .765 | - | ESPN | Fertitta Center · Houston, TX |
| 35 | Fri Mar 17 | vs#9FAU | L65-66 | 26-9 | .743 | #8 | TNT | FedExForum · Memphis, TN |
