| 1 | Mon Nov 6 | vs Jackson St | W94-77 | 1-0 | 1.000 | - | | FedExForum · Memphis, TN |
| 2 | Fri Nov 10 | atMissouri | W70-55 | 2-0 | 1.000 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 3 | Fri Nov 17 | vsAlabama St | W92-75 | 3-0 | 1.000 | - | | FedExForum · Memphis, TN |
| 4 | Wed Nov 22 | atMichigan | W71-67 | 4-0 | 1.000 | - | ESPN2 | Crisler Center · Ann Arbor, MI |
| 5 | Thu Nov 23 | vs#20Arkansas | W84-79 | 5-0 | 1.000 | - | ESPN2 | FedExForum · Memphis, TN |
| 6 | Fri Nov 24 | atVillanova | L63-79 | 5-1 | .833 | - | ESPNU | Finneran Pavilion · Villanova, PA |
| 7 | Sat Dec 2 | atOle Miss | L77-80 | 5-2 | .714 | - | ESPN2 | SJB Pavilion · Oxford, MS |
| 8 | Wed Dec 6 | atVCU | W85-80 (OT) | 6-2 | .750 | - | ESPNU | Stuart C. Siegel Center · Richmond, VA |
| 9 | Sun Dec 10 | at#21Texas A&M | W81-75 | 7-2 | .778 | - | ESPN2 | Reed Arena · College Station, TX |
| 10 | Sat Dec 16 | vs#13Clemson | W79-77 | 8-2 | .800 | - | | FedExForum · Memphis, TN |
| 11 | Tue Dec 19 | vs#22Virginia | W77-54 | 9-2 | .818 | #23 | ESPN2 | FedExForum · Memphis, TN |
| 12 | Sat Dec 23 | vsVanderbilt | W77-75 | 10-2 | .833 | #23 | CBS | FedExForum · Memphis, TN |
| 13 | Sat Dec 30 | vsAustin Peay | W81-70 | 11-2 | .846 | #19 | | FedExForum · Memphis, TN |
| 14 | Thu Jan 4 | atTulsa | W78-75 | 12-2 | .857 | #15 | | Donald W. Reynolds Center · Tulsa, OK |
| 15 | Sun Jan 7 | vsSMU | W62-59 | 13-2 | .867 | #15 | ESPN | FedExForum · Memphis, TN |
| 16 | Wed Jan 10 | vsUTSA | W107-101 (OT) | 14-2 | .875 | #13 | | FedExForum · Memphis, TN |
| 17 | Sun Jan 14 | atWichita St | W112-86 | 15-2 | .882 | #13 | ESPN2 | Charles Koch Arena · Wichita, KS |
| 18 | Thu Jan 18 | vsSouth Florida | L73-74 | 15-3 | .833 | #10 | ESPN | FedExForum · Memphis, TN |
| 19 | Sun Jan 21 | atTulane | L79-81 | 15-4 | .789 | #10 | ESPN2 | Devlin Fieldhouse · New Orleans, LA |
| 20 | Sun Jan 28 | atUAB | L88-97 | 15-5 | .750 | #19 | ESPN | Bartow Arena · Birmingham, AL |
| 21 | Wed Jan 31 | vsRice | L71-74 | 15-6 | .714 | - | | FedExForum · Memphis, TN |
| 22 | Sat Feb 3 | vsWichita St | W65-63 | 16-6 | .727 | - | CBS | FedExForum · Memphis, TN |
| 23 | Thu Feb 8 | atTemple | W84-77 | 17-6 | .739 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 24 | Sun Feb 11 | vsTulane | W90-78 | 18-6 | .750 | - | ESPN2 | FedExForum · Memphis, TN |
| 25 | Thu Feb 15 | atNorth Texas | L66-76 | 18-7 | .720 | - | | The Super Pit · Denton, TX |
| 26 | Sun Feb 18 | atSMU | L79-106 | 18-8 | .692 | - | ESPN | Moody Coliseum · Dallas, TX |
| 27 | Wed Feb 21 | vsCharlotte | W76-52 | 19-8 | .704 | - | | FedExForum · Memphis, TN |
| 28 | Sun Feb 25 | vsFAU | W78-74 | 20-8 | .714 | - | ESPN | FedExForum · Memphis, TN |
| 29 | Thu Feb 29 | atE Carolina | W82-58 | 21-8 | .724 | - | ESPN2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 30 | Sun Mar 3 | vsUAB | W106-87 | 22-8 | .733 | - | ESPN2 | FedExForum · Memphis, TN |
| 31 | Sat Mar 9 | atFAU | L84-92 | 22-9 | .710 | - | CBS | FAU Arena · Boca Raton, FL |
| 32 | Thu Mar 14 | vsWichita St | L65-71 | 22-10 | .688 | - | ESPNU | FedExForum · Memphis, TN |
