| 1 | Tue Nov 5 | vs SC State | W97-64 | 1-0 | 1.000 | #14 | | FedExForum · Memphis, TN |
| 2 | Fri Nov 8 | vsUIC | W92-46 | 2-0 | 1.000 | - | ESPNU | FedExForum · Memphis, TN |
| 3 | Tue Nov 12 | vsOregon | L74-82 | 2-1 | .667 | - | ESPN | Moda Center · Portland, OR |
| 4 | Sat Nov 16 | vsAlcorn St | W102-56 | 3-1 | .750 | - | | FedExForum · Memphis, TN |
| 5 | Wed Nov 20 | vsLittle Rock | W68-58 | 4-1 | .800 | - | | FedExForum · Memphis, TN |
| 6 | Sat Nov 23 | vsOle Miss | W87-86 | 5-1 | .833 | #16 | | FedExForum · Memphis, TN |
| 7 | Thu Nov 28 | vsNC State | W83-78 | 6-1 | .857 | - | ESPN2 | FedExForum · Memphis, TN |
| 8 | Tue Dec 3 | vsBradley | W71-56 | 7-1 | .875 | #15 | CBSSN | FedExForum · Memphis, TN |
| 9 | Sat Dec 7 | atUAB | W65-57 | 8-1 | .889 | #15 | CBSSN | Bartow Arena · Birmingham, AL |
| 10 | Sat Dec 14 | at19Tennessee | W51-47 | 9-1 | .900 | #13 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 11 | Sat Dec 21 | vsJackson St | W77-49 | 10-1 | .909 | #11 | | FedExForum · Memphis, TN |
| 12 | Sat Dec 28 | vsNew Orleans | W97-55 | 11-1 | .917 | #9 | ESPN2 | FedExForum · Memphis, TN |
| 13 | Mon Dec 30 | vsTulane | W84-73 | 12-1 | .923 | #9 | CBSSN | FedExForum · Memphis, TN |
| 14 | Sat Jan 4 | vsGeorgia | L62-65 | 12-2 | .857 | #9 | CBS | FedExForum · Memphis, TN |
| 15 | Thu Jan 9 | at23Wichita St | L67-76 | 12-3 | .800 | #21 | ESPN2 | Charles Koch Arena · Wichita, KS |
| 16 | Sun Jan 12 | atSouth Florida | W68-64 | 13-3 | .813 | #21 | ESPN2 | Yuengling Center · Tampa, FL |
| 17 | Thu Jan 16 | vsCincinnati | W60-49 | 14-3 | .824 | #22 | ESPN | FedExForum · Memphis, TN |
| 18 | Wed Jan 22 | atTulsa | L40-80 | 14-4 | .778 | #20 | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 19 | Sat Jan 25 | vsSMU | L70-74 | 14-5 | .737 | #20 | CBSSN | FedExForum · Memphis, TN |
| 20 | Wed Jan 29 | atUCF | W59-57 | 15-5 | .750 | - | ESPNU | Addition Financial Arena · Orlando, FL |
| 21 | Sat Feb 1 | vsUConn | W70-63 | 16-5 | .762 | - | CBS | FedExForum · Memphis, TN |
| 22 | Wed Feb 5 | vsTemple | W79-65 | 17-5 | .773 | - | CBSSN | FedExForum · Memphis, TN |
| 23 | Sat Feb 8 | vsSouth Florida | L73-75 | 17-6 | .739 | - | CBSSN | FedExForum · Memphis, TN |
| 24 | Thu Feb 13 | atCincinnati | L86-92 (OT) | 17-7 | .708 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 25 | Sun Feb 16 | atUConn | L61-64 | 17-8 | .680 | - | ESPN | Gampel Pavilion · Storrs, CT |
| 26 | Wed Feb 19 | vsE Carolina | W77-73 | 18-8 | .692 | - | CBSSN | FedExForum · Memphis, TN |
| 27 | Sat Feb 22 | vs22Houston | W60-59 | 19-8 | .704 | - | ESPN2 | FedExForum · Memphis, TN |
| 28 | Tue Feb 25 | atSMU | L53-58 | 19-9 | .679 | - | CBSSN | Moody Coliseum · Dallas, TX |
| 29 | Sat Feb 29 | atTulane | W74-67 (OT) | 20-9 | .690 | - | CBSSN | Devlin Fieldhouse · New Orleans, LA |
| 30 | Thu Mar 5 | vsWichita St | W68-60 | 21-9 | .700 | - | ESPN | FedExForum · Memphis, TN |
| 31 | Sun Mar 8 | at21Houston | L57-64 | 21-10 | .677 | - | CBS | Fertitta Center · Houston, TX |
