| 1 | Sat Nov 8 | vs San Francisco | W76-70 | 1-0 | 1.000 | - | ESPN+ | FedExForum · Memphis, TN |
| 2 | Tue Nov 11 | atOle Miss | L77-83 | 1-1 | .500 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 3 | Sun Nov 16 | vsUNLV | L78-92 | 1-2 | .333 | - | ESPN | FedExForum · Memphis, TN |
| 4 | Thu Nov 20 | at1Purdue | L71-80 | 1-3 | .250 | - | CBSSN | Mackey Arena · West Lafayette, IN |
| 5 | Fri Nov 21 | vsWake Forest | L68-69 | 1-4 | .200 | - | CBSSN | FedExForum · Memphis, TN |
| 6 | Wed Nov 26 | vsS Illinois | W74-58 | 2-4 | .333 | - | ESPN+ | FedExForum · Memphis, TN |
| 7 | Wed Dec 3 | vsNew Orleans | W86-70 | 3-4 | .429 | - | ESPN+ | FedExForum · Memphis, TN |
| 8 | Sat Dec 6 | vsBaylor | W78-71 | 4-4 | .500 | - | CBS | FedExForum · Memphis, TN |
| 9 | Sat Dec 13 | at11Louisville | L73-99 | 4-5 | .444 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 10 | Wed Dec 17 | vs13Vanderbilt | L70-77 (OT) | 4-6 | .400 | - | ESPN2 | FedExForum · Memphis, TN |
| 11 | Sat Dec 20 | atMississippi St | L66-71 | 4-7 | .364 | - | ESPN | Humphrey Coliseum · Starkville, MS |
| 12 | Mon Dec 22 | vsAlabama St | W88-67 | 5-7 | .417 | - | | FedExForum · Memphis, TN |
| 13 | Wed Dec 31 | vsNorth Texas | W57-48 | 6-7 | .462 | - | ESPN2 | FedExForum · Memphis, TN |
| 14 | Sat Jan 3 | atRice | W76-70 | 7-7 | .500 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 15 | Sun Jan 11 | atFAU | L78-89 | 7-8 | .467 | - | ESPN2 | FAU Arena · Boca Raton, FL |
| 16 | Wed Jan 14 | vsTemple | W55-53 | 8-8 | .500 | - | ESPN+ | FedExForum · Memphis, TN |
| 17 | Sun Jan 18 | vsUTSA | W95-69 | 9-8 | .529 | - | ESPNU | FedExForum · Memphis, TN |
| 18 | Wed Jan 21 | atTulsa | L66-83 | 9-9 | .500 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 19 | Sat Jan 24 | atWichita St | L59-74 | 9-10 | .474 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 20 | Thu Jan 29 | vsFAU | W92-65 | 10-10 | .500 | - | ESPN2 | FedExForum · Memphis, TN |
| 21 | Sun Feb 1 | vsTulane | L76-78 | 10-11 | .476 | - | ESPN2 | FedExForum · Memphis, TN |
| 22 | Thu Feb 5 | atUAB | W90-80 | 11-11 | .500 | - | ESPN2 | Bartow Arena · Birmingham, AL |
| 23 | Sun Feb 8 | vsCharlotte | W77-54 | 12-11 | .522 | - | ESPN+ | FedExForum · Memphis, TN |
| 24 | Thu Feb 12 | atNorth Texas | L69-76 | 12-12 | .500 | - | ESPN | The Super Pit · Denton, TX |
| 25 | Sat Feb 14 | atUtah State | L75-99 | 12-13 | .480 | - | CBSSN | Dee Glen Smith Spectrum · Logan, UT |
| 26 | Thu Feb 19 | atSouth Florida | L66-87 | 12-14 | .462 | - | ESPN2 | Yuengling Center · Tampa, FL |
| 27 | Sun Feb 22 | vsUAB | L67-78 | 12-15 | .444 | - | ESPN2 | FedExForum · Memphis, TN |
| 28 | Thu Feb 26 | vsWichita St | L82-88 | 12-16 | .429 | - | ESPN2 | FedExForum · Memphis, TN |
| 29 | Sun Mar 1 | atE Carolina | L68-84 | 12-17 | .414 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
