| 1 | Tue Nov 9 | vs Tennessee Tech | W89-65 | 1-0 | 1.000 | #12 | | FedExForum · Memphis, TN |
| 2 | Sat Nov 13 | vsNC Central | W90-51 | 2-0 | 1.000 | #12 | | FedExForum · Memphis, TN |
| 3 | Tue Nov 16 | vsSaint Louis | W90-74 | 3-0 | 1.000 | #11 | | FedExForum · Memphis, TN |
| 4 | Fri Nov 19 | vsWestern KY | W74-62 | 4-0 | 1.000 | #11 | | FedExForum · Memphis, TN |
| 5 | Wed Nov 24 | atVirginia Tech | W69-61 | 5-0 | 1.000 | - | ESPNEWS | Cassell Coliseum · Blacksburg, VA |
| 6 | Fri Nov 26 | vsIowa State | L59-78 | 5-1 | .833 | - | ESPN2 | FedExForum · Memphis, TN |
| 7 | Wed Dec 1 | atGeorgia | L79-82 | 5-2 | .714 | #18 | SEC Network | Stegeman Coliseum · Athens, GA |
| 8 | Sat Dec 4 | atOle Miss | L63-67 | 5-3 | .625 | #18 | ESPN2 | SJB Pavilion · Oxford, MS |
| 9 | Fri Dec 10 | vsMurray St | L72-74 | 5-4 | .556 | - | | FedExForum · Memphis, TN |
| 10 | Tue Dec 14 | vs6Alabama | W92-78 | 6-4 | .600 | - | ESPN | FedExForum · Memphis, TN |
| 13 | Wed Dec 29 | atTulane | L84-85 | 6-5 | .545 | - | | Devlin Fieldhouse · New Orleans, LA |
| 14 | Sat Jan 1 | atWichita St | W82-64 | 7-5 | .583 | - | CBS | Charles Koch Arena · Wichita, KS |
| 15 | Tue Jan 4 | vsTulsa | W67-64 | 8-5 | .615 | - | ESPNU | FedExForum · Memphis, TN |
| 16 | Sun Jan 9 | vsCincinnati | W87-80 | 9-5 | .643 | - | ABC | FedExForum · Memphis, TN |
| 17 | Wed Jan 12 | atUCF | L64-74 | 9-6 | .600 | - | | Addition Financial Arena · Orlando, FL |
| 18 | Sat Jan 15 | atE Carolina | L71-72 | 9-7 | .563 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 19 | Thu Jan 20 | vsSMU | L62-70 | 9-8 | .529 | - | ESPN2 | FedExForum · Memphis, TN |
| 20 | Sun Jan 23 | atTulsa | W83-81 | 10-8 | .556 | - | ESPN | Donald W. Reynolds Center · Tulsa, OK |
| 21 | Thu Jan 27 | vsE Carolina | W71-54 | 11-8 | .579 | - | ESPN2 | FedExForum · Memphis, TN |
| 22 | Thu Feb 3 | atCincinnati | PPD | 22-11 | .667 | - | | Fifth Third Arena · Cincinnati, OH |
| 23 | Sat Feb 5 | vsUCF | W88-60 | 12-8 | .600 | - | ESPN2 | FedExForum · Memphis, TN |
| 24 | Wed Feb 9 | vsTulane | W80-69 | 13-8 | .619 | - | | FedExForum · Memphis, TN |
| 25 | Sat Feb 12 | at6Houston | W69-59 | 14-8 | .636 | - | ABC | Fertitta Center · Houston, TX |
| 26 | Tue Feb 15 | atCincinnati | W81-74 | 15-8 | .652 | - | | Fifth Third Arena · Cincinnati, OH |
| 27 | Sun Feb 20 | atSMU | L57-73 | 15-9 | .625 | - | ESPN | Moody Coliseum · Dallas, TX |
| 28 | Thu Feb 24 | vsTemple | W78-64 | 16-9 | .640 | - | ESPN2 | FedExForum · Memphis, TN |
| 29 | Sun Feb 27 | vsWichita St | W81-57 | 17-9 | .654 | - | ESPN | FedExForum · Memphis, TN |
| 30 | Thu Mar 3 | atSouth Florida | W73-64 | 18-9 | .667 | - | ESPNU | Yuengling Center · Tampa, FL |
| 31 | Sun Mar 6 | vs14Houston | W75-61 | 19-9 | .679 | - | CBS | FedExForum · Memphis, TN |
| 32 | Fri Mar 11 | vsUCF | W85-69 | 20-9 | .690 | - | ESPNU | FedExForum · Memphis, TN |
| 33 | Sat Mar 12 | atSMU | W70-63 | 21-9 | .700 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 34 | Sun Mar 13 | atHouston | L53-71 | 21-10 | .677 | - | ESPN | Fertitta Center · Houston, TX |
| 33 | Thu Mar 17 | at8Boise St | W64-53 | 22-10 | .688 | #9 | TNT | Moda Center · Portland, OR |
| 34 | Sat Mar 19 | at1Gonzaga | L78-82 | 22-11 | .667 | #9 | TBS | Moda Center · Portland, OR |
