| 1 | Mon Nov 4 | vs UNC Asheville | W110-54 | 1-0 | 1.000 | #2 | ESPNU | Coleman Coliseum · Tuscaloosa, AL |
| 2 | Fri Nov 8 | vs Arkansas St | W88-79 | 2-0 | 1.000 | #2 | ESPN+ | Coleman Coliseum · Tuscaloosa, AL |
| 3 | Mon Nov 11 | vs McNeese | W72-64 | 3-0 | 1.000 | #2 | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 4 | Fri Nov 15 | at #13Purdue | L78-87 | 3-1 | .750 | #2 | Peacock | Mackey Arena · West Lafayette, IN |
| 5 | Wed Nov 20 | vs #25Illinois | W100-87 | 4-1 | .800 | #8 | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 6 | Tue Nov 26 | at #6Houston | W85-80 (OT) | 5-1 | .833 | #9 | TBS | Fertitta Center · Houston, TX |
| 7 | Wed Nov 27 | at Rutgers | W95-90 | 6-1 | .857 | #9 | TBS | Jersey Mike’s Arena · Piscataway, NJ |
| 8 | Sat Nov 30 | vs Oregon | L81-83 | 6-2 | .750 | #9 | TNT | Coleman Coliseum · Tuscaloosa, AL |
| 9 | Wed Dec 4 | at #20UNC | W94-79 | 7-2 | .778 | #10 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 10 | Sat Dec 14 | vs Creighton | W83-75 | 8-2 | .800 | #7 | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 11 | Wed Dec 18 | at North Dakota | W97-90 | 9-2 | .818 | #6 | CBS | Betty Engelstad Sioux Center · Grand Forks, ND |
| 12 | Sun Dec 22 | vs Kent State | W81-54 | 10-2 | .833 | #6 | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 13 | Sun Dec 29 | vs S Dakota St | W105-82 | 11-2 | .846 | #5 | ESPN+ | Coleman Coliseum · Tuscaloosa, AL |
| 14 | Sat Jan 4 | vs #12Oklahoma | W107-79 | 12-2 | .857 | #5 | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 15 | Wed Jan 8 | at South Carolina | W88-68 | 13-2 | .867 | #5 | SEC Network | Colonial Life Arena · Columbia, SC |
| 16 | Sat Jan 11 | at #10Texas A&M | W94-88 | 14-2 | .875 | #5 | ESPN | Reed Arena · College Station, TX |
| 17 | Tue Jan 14 | vs #21Ole Miss | L64-74 | 14-3 | .824 | #4 | ESPNU | Coleman Coliseum · Tuscaloosa, AL |
| 18 | Sat Jan 18 | at #8Kentucky | W102-97 | 15-3 | .833 | #4 | ESPN | Rupp Arena · Lexington, KY |
| 19 | Tue Jan 21 | vs Vanderbilt | W103-87 | 16-3 | .842 | #4 | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 20 | Sat Jan 25 | vs LSU | W80-73 | 17-3 | .850 | #4 | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 21 | Wed Jan 29 | at #14Mississippi St | W88-84 | 18-3 | .857 | #4 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 22 | Sat Feb 1 | vs Georgia | W90-69 | 19-3 | .864 | #4 | ESPN2 | Coleman Coliseum · Tuscaloosa, AL |
| 23 | Sat Feb 8 | at Arkansas | W85-81 | 20-3 | .870 | #3 | ESPN | Bud Walton Arena · Fayetteville, AR |
| 24 | Tue Feb 11 | at Texas | W103-80 | 21-3 | .875 | #2 | ESPN | Moody Center · Austin, TX |
| 25 | Sat Feb 15 | vs #1Auburn | L85-94 | 21-4 | .840 | #2 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 26 | Wed Feb 19 | at #15Missouri | L98-110 | 21-5 | .808 | #4 | SEC Network | Mizzou Arena · Columbia, MO |
#6Tennessee
#2Florida