| 1 | Mon Nov 4 | vs North Florida | L71-74 | 0-1 | .000 | - | ESPN+ | Colonial Life Arena · Columbia, SC |
| 2 | Fri Nov 8 | vs SC State | W86-64 | 1-1 | .500 | - | ESPN+ | Colonial Life Arena · Columbia, SC |
| 3 | Tue Nov 12 | vs Towson | W80-54 | 2-1 | .667 | - | ESPN+ | Colonial Life Arena · Columbia, SC |
| 4 | Sat Nov 16 | at #16Indiana | L71-87 | 2-2 | .500 | - | Peacock | Simon Skjodt Assembly Hall · Bloomington, IN |
| 5 | Thu Nov 21 | vs Mercer | W84-72 | 3-2 | .600 | - | ESPN+ | Colonial Life Arena · Columbia, SC |
| 6 | Mon Nov 25 | vs #22Xavier | L66-75 | 3-3 | .500 | - | FS1 | Colonial Life Arena · Columbia, SC |
| 7 | Wed Nov 27 | at Virginia Tech | W70-60 | 4-3 | .571 | - | FS1 | Cassell Coliseum · Blacksburg, VA |
| 8 | Tue Dec 3 | at Boston College | W73-51 | 5-3 | .625 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 9 | Sat Dec 7 | vs E Carolina | W75-68 | 6-3 | .667 | - | ESPN+ | Colonial Life Arena · Columbia, SC |
| 10 | Sat Dec 14 | vs SC Upstate | W73-53 | 7-3 | .700 | - | ESPN+ | Colonial Life Arena · Columbia, SC |
| 11 | Tue Dec 17 | vs #25Clemson | W91-88 (OT) | 8-3 | .727 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 12 | Sun Dec 22 | vs Radford | W74-48 | 9-3 | .750 | - | ESPN+ | Colonial Life Arena · Columbia, SC |
| 13 | Mon Dec 30 | vs Presbyterian | W69-59 | 10-3 | .769 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 14 | Sat Jan 4 | at #17Mississippi St | L50-85 | 10-4 | .714 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 15 | Wed Jan 8 | vs #5Alabama | L68-88 | 10-5 | .667 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 16 | Sat Jan 11 | vs #2Auburn | L63-66 | 10-6 | .625 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 17 | Wed Jan 15 | at Vanderbilt | L63-66 | 10-7 | .588 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 18 | Sat Jan 18 | at Oklahoma | L62-82 | 10-8 | .556 | - | ESPNU | Lloyd Noble Center · Norman, OK |
| 19 | Wed Jan 22 | vs #5Florida | L69-70 | 10-9 | .526 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 20 | Sat Jan 25 | vs#14Mississippi St | L60-65 (OT) | 10-10 | .500 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 21 | Tue Jan 28 | at Georgia | L60-71 | 10-11 | .476 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 22 | Sat Feb 1 | vs #13Texas A&M | L72-76 | 10-12 | .455 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 23 | Sat Feb 8 | at #14Kentucky | L57-80 | 10-13 | .435 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 24 | Wed Feb 12 | vs #19Ole Miss | L68-72 | 10-14 | .417 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 25 | Sat Feb 15 | at#3Florida | L67-88 | 10-15 | .400 | - | SEC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 26 | Tue Feb 18 | at LSU | L67-81 | 10-16 | .385 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
Texas
#15Missouri
Arkansas
#6Tennessee