| 1 | Tue Nov 8 | vs SC State | W80-77 | 1-0 | 1.000 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 2 | Fri Nov 11 | vsClemson | W60-58 | 2-0 | 1.000 | - | | Colonial Life Arena · Columbia, SC |
| 3 | Thu Nov 17 | vsColorado St | L53-85 | 2-1 | .667 | - | ESPNU | TD Arena · Charleston, SC |
| 4 | Fri Nov 18 | atDavidson | L60-69 | 2-2 | .500 | - | ESPNEWS | TD Arena · Charleston, SC |
| 5 | Sun Nov 20 | vsFurman | L60-79 | 2-3 | .400 | - | ESPNEWS | TD Arena · Charleston, SC |
| 6 | Fri Nov 25 | vsSC Upstate | W68-53 | 3-3 | .500 | - | | TD Arena · Charleston, SC |
| 7 | Wed Nov 30 | atG Washington | L55-79 | 3-4 | .429 | - | CBSSN | Charles E. Smith Center · Washington, D.C. |
| 8 | Sat Dec 3 | atGeorgetown | W74-71 (OT) | 4-4 | .500 | - | FS1 | Capital One Arena · Washington, D.C. |
| 9 | Sun Dec 11 | vsPresbyterian | W68-57 | 5-4 | .556 | - | | Colonial Life Arena · Columbia, SC |
| 10 | Wed Dec 14 | atUAB | L70-84 | 5-5 | .500 | - | CBSSN | Bartow Arena · Birmingham, AL |
| 11 | Sat Dec 17 | vsE Carolina | L56-64 | 5-6 | .455 | - | | Colonial Life Arena · Columbia, SC |
| 12 | Thu Dec 22 | vsWestern KY | W65-58 | 6-6 | .500 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 13 | Fri Dec 30 | vsE Michigan | W74-64 | 7-6 | .538 | - | | Colonial Life Arena · Columbia, SC |
| 14 | Tue Jan 3 | atVanderbilt | L79-84 (OT) | 7-7 | .500 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 15 | Sat Jan 7 | vs#8Tennessee | L42-85 | 7-8 | .467 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 16 | Tue Jan 10 | atKentucky | W71-68 | 8-8 | .500 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 17 | Sat Jan 14 | vsTexas A&M | L53-94 | 8-9 | .471 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 18 | Tue Jan 17 | vsOle Miss | L58-70 | 8-10 | .444 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 19 | Sat Jan 21 | vs#16Auburn | L66-81 | 8-11 | .421 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 20 | Wed Jan 25 | atFlorida | L60-81 | 8-12 | .400 | - | ESPN2 | O'Connell Center · Gainesville, FL |
| 21 | Sat Jan 28 | atGeorgia | L78-81 (OT) | 8-13 | .381 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 22 | Tue Jan 31 | vsMississippi St | L51-66 | 8-14 | .364 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 23 | Sat Feb 4 | vsArkansas | L63-65 | 8-15 | .348 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 24 | Tue Feb 7 | atMissouri | L74-83 | 8-16 | .333 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 25 | Sat Feb 11 | atOle Miss | W64-61 | 9-16 | .360 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 26 | Tue Feb 14 | vsVanderbilt | L64-75 | 9-17 | .346 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 27 | Sat Feb 18 | atLSU | W82-73 | 10-17 | .370 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 28 | Wed Feb 22 | vs#2Alabama | L76-78 (OT) | 10-18 | .357 | - | ESPN2 | Colonial Life Arena · Columbia, SC |
| 29 | Sat Feb 25 | at#11Tennessee | L45-85 | 10-19 | .345 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 30 | Tue Feb 28 | atMississippi St | L68-74 | 10-20 | .333 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 31 | Sat Mar 4 | vsGeorgia | W61-55 | 11-20 | .355 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 32 | Wed Mar 8 | vsOle Miss | L61-67 | 11-21 | .344 | - | SEC Network | Colonial Life Arena · Columbia, SC |
