| 1 | Mon Nov 6 | vs SC Upstate | W82-53 | 1-0 | 1.000 | - | | Colonial Life Arena · Columbia, SC |
| 2 | Fri Nov 10 | vs Virginia Tech | W79-77 | 2-0 | 1.000 | - | ACC Network | Colonial Life Arena · Columbia, SC |
| 3 | Mon Nov 13 | vs VMI | W74-64 | 3-0 | 1.000 | - | | Colonial Life Arena · Columbia, SC |
| 4 | Fri Nov 17 | at DePaul | W73-68 | 4-0 | 1.000 | - | CBS | Wintrust Arena · Chicago, IL |
| 5 | Sun Nov 19 | at Grand Canyon | W75-68 | 5-0 | 1.000 | - | CBS | GCU Arena · Phoenix, AZ |
| 6 | Tue Nov 28 | vs Notre Dame | W65-53 | 6-0 | 1.000 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 7 | Fri Dec 1 | vs G Washington | W89-67 | 7-0 | 1.000 | - | | Colonial Life Arena · Columbia, SC |
| 8 | Wed Dec 6 | at #24Clemson | L67-72 | 7-1 | .875 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 9 | Sat Dec 9 | at E Carolina | W68-62 | 8-1 | .889 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 10 | Sat Dec 16 | vs Charleston So | W73-69 | 9-1 | .900 | - | | Colonial Life Arena · Columbia, SC |
| 11 | Tue Dec 19 | vs Winthrop | W72-62 | 10-1 | .909 | - | | Colonial Life Arena · Columbia, SC |
| 12 | Fri Dec 22 | vs Elon | W70-43 | 11-1 | .917 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 13 | Sat Dec 30 | vs FAMU | W94-62 | 12-1 | .923 | - | | Colonial Life Arena · Columbia, SC |
| 14 | Sat Jan 6 | vs Mississippi St | W68-62 | 13-1 | .929 | - | CBS | Colonial Life Arena · Columbia, SC |
| 15 | Tue Jan 9 | at Alabama | L47-74 | 13-2 | .867 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 16 | Sat Jan 13 | at Missouri | W71-69 (OT) | 14-2 | .875 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 17 | Tue Jan 16 | vs Georgia | L69-74 | 14-3 | .824 | - | ESPNU | Colonial Life Arena · Columbia, SC |
| 18 | Sat Jan 20 | at Arkansas | W77-64 | 15-3 | .833 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 19 | Tue Jan 23 | vs #6Kentucky | W79-62 | 16-3 | .842 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 20 | Sat Jan 27 | vsMissouri | W72-64 | 17-3 | .850 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 21 | Tue Jan 30 | at #5Tennessee | W63-59 | 18-3 | .857 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 22 | Sat Feb 3 | atGeorgia | W72-62 | 19-3 | .864 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 23 | Tue Feb 6 | vs Ole Miss | W68-65 | 20-3 | .870 | #15 | SEC Network | Colonial Life Arena · Columbia, SC |
| 24 | Sat Feb 10 | vs Vanderbilt | W75-60 | 21-3 | .875 | #15 | SEC Network | Colonial Life Arena · Columbia, SC |
| 25 | Wed Feb 14 | at #13Auburn | L61-101 | 21-4 | .840 | #11 | SEC Network | Neville Arena · Auburn, AL |
| 26 | Sat Feb 17 | vs LSU | L63-64 | 21-5 | .808 | #11 | SEC Network | Colonial Life Arena · Columbia, SC |
| 27 | Sat Feb 24 | atOle Miss | W72-59 | 22-5 | .815 | #20 | SEC Network | SJB Pavilion · Oxford, MS |
| 28 | Wed Feb 28 | at Texas A&M | W70-68 | 23-5 | .821 | #18 | SEC Network | Reed Arena · College Station, TX |
| 29 | Sat Mar 2 | vs #24Florida | W82-76 | 24-5 | .828 | #18 | ESPN | Colonial Life Arena · Columbia, SC |
| 30 | Wed Mar 6 | vs#4Tennessee | L59-66 | 24-6 | .800 | #17 | ESPN2 | Colonial Life Arena · Columbia, SC |
| 31 | Sat Mar 9 | atMississippi St | W93-89 (OT) | 25-6 | .806 | #17 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 32 | Thu Mar 14 | vsArkansas | W80-66 | 26-6 | .813 | #15 | SEC Network | Colonial Life Arena · Columbia, SC |
| 33 | Fri Mar 15 | at#12Auburn | L55-86 | 26-7 | .788 | #15 | ESPN | Neville Arena · Auburn, AL |
| 34 | Thu Mar 21 | vs #11Oregon | L73-87 | 26-8 | .765 | #6 | TNT | Colonial Life Arena · Columbia, SC |
