| 1 | Tue Nov 9 | vs SC Upstate | W78-60 | 1-0 | 1.000 | - | | Colonial Life Arena · Columbia, SC |
| 2 | Fri Nov 12 | vs Princeton | L62-66 | 1-1 | .500 | - | ESPNEWS | Colonial Life Arena · Columbia, SC |
| 3 | Sun Nov 14 | vs Western KY | W75-64 | 2-1 | .667 | - | ESPNU | Colonial Life Arena · Columbia, SC |
| 4 | Thu Nov 18 | vs UAB | W66-63 | 3-1 | .750 | - | | Colonial Life Arena · Columbia, SC |
| 5 | Tue Nov 23 | vs Wofford | W85-74 | 4-1 | .800 | - | | Colonial Life Arena · Columbia, SC |
| 6 | Sun Nov 28 | vs Rider | W65-58 | 5-1 | .833 | - | | Colonial Life Arena · Columbia, SC |
| 7 | Wed Dec 1 | at Coast Car | L56-80 | 5-2 | .714 | - | | The HTC Center · Conway, SC |
| 8 | Sun Dec 5 | vs Georgetown | W80-67 | 6-2 | .750 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 9 | Sun Dec 12 | vs Florida St | W66-65 | 7-2 | .778 | - | ESPN2 | Colonial Life Arena · Columbia, SC |
| 10 | Tue Dec 14 | vs TBD | W110-51 | 8-2 | .800 | - | | Colonial Life Arena · Columbia, SC |
| 11 | Sat Dec 18 | at Clemson | L56-70 | 8-3 | .727 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 12 | Wed Dec 22 | vs Army | W105-75 | 9-3 | .750 | - | | Colonial Life Arena · Columbia, SC |
| 14 | Tue Jan 4 | vs #9Auburn | L66-81 | 9-4 | .692 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 15 | Sat Jan 8 | at Vanderbilt | W72-70 | 10-4 | .714 | - | ESPNU | Memorial Gymnasium (TN) · Nashville, TN |
| 16 | Tue Jan 11 | at #22Tennessee | L46-66 | 10-5 | .667 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 17 | Sat Jan 15 | vs Florida | L63-71 | 10-6 | .625 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 18 | Tue Jan 18 | at Arkansas | L59-75 | 10-7 | .588 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 19 | Sat Jan 22 | vs Georgia | W83-66 | 11-7 | .611 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 20 | Wed Jan 26 | vsVanderbilt | W70-61 | 12-7 | .632 | - | ESPNU | Colonial Life Arena · Columbia, SC |
| 21 | Sat Jan 29 | at Texas A&M | W74-63 | 13-7 | .650 | - | SEC Network | Reed Arena · College Station, TX |
| 22 | Tue Feb 1 | at Mississippi St | L64-78 | 13-8 | .619 | - | ESPNU | Humphrey Coliseum · Starkville, MS |
| 23 | Sat Feb 5 | vs#22Tennessee | L57-81 | 13-9 | .591 | - | CBS | Colonial Life Arena · Columbia, SC |
| 24 | Tue Feb 8 | vs #5Kentucky | L76-86 | 13-10 | .565 | - | ESPN | Colonial Life Arena · Columbia, SC |
| 25 | Sat Feb 12 | atGeorgia | W80-68 | 14-10 | .583 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 26 | Tue Feb 15 | at Ole Miss | W77-74 (OT) | 15-10 | .600 | - | ESPNU | SJB Pavilion · Oxford, MS |
| 27 | Sat Feb 19 | vs LSU | W77-75 | 16-10 | .615 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 28 | Wed Feb 23 | vsMississippi St | W66-56 | 17-10 | .630 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 29 | Sat Feb 26 | at #24Alabama | L71-90 | 17-11 | .607 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 30 | Tue Mar 1 | vs Missouri | W73-69 | 18-11 | .621 | - | ESPNU | Colonial Life Arena · Columbia, SC |
| 31 | Sat Mar 5 | at#5Auburn | L71-82 | 18-12 | .600 | - | SEC Network | Neville Arena · Auburn, AL |
| 32 | Thu Mar 10 | vsMississippi St | L51-73 | 18-13 | .581 | - | SEC Network | Colonial Life Arena · Columbia, SC |
