| 1 | Mon Nov 4 | vs TBD | W112-58 | 1-0 | 1.000 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 2 | Sat Nov 9 | at Lipscomb | L69-78 | 1-1 | .500 | - | ESPN+ | Allen Arena · Nashville, TN |
| 3 | Wed Nov 13 | at Presbyterian | L68-71 | 1-2 | .333 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 4 | Sat Nov 16 | at #6Duke | L35-86 | 1-3 | .250 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 5 | Fri Nov 22 | vs St Thomas (MN) | W81-73 | 2-3 | .400 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 6 | Sat Nov 23 | at Milwaukee | L74-76 | 2-4 | .333 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 7 | Sun Nov 24 | at Portland St | L74-79 | 2-5 | .286 | - | | Viking Pavilion · Portland, OR |
| 8 | Sun Dec 1 | vs North Alabama | W74-54 | 3-5 | .375 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 9 | Wed Dec 4 | vs Gardner-Webb | W88-64 | 4-5 | .444 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 10 | Sat Dec 7 | at Elon | L56-79 | 4-6 | .400 | - | | Schar Center · Elon, NC |
| 11 | Mon Dec 16 | at Charleston | L67-77 | 4-7 | .364 | - | | TD Arena · Charleston, SC |
| 12 | Wed Dec 18 | at Saint Louis | W74-71 | 5-7 | .417 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 13 | Sat Dec 28 | vsTBD | W100-55 | 6-7 | .462 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 14 | Wed Jan 1 | vs UNC Greensboro | L66-68 | 6-8 | .429 | - | CBS | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 15 | Sat Jan 4 | at ETSU | W81-78 | 7-8 | .467 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 16 | Wed Jan 8 | vs W Carolina | W77-69 | 8-8 | .500 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 17 | Mon Jan 13 | at Furman | W81-62 | 9-8 | .529 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 18 | Wed Jan 15 | at Chattanooga | L81-83 (OT) | 9-9 | .500 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
| 19 | Sat Jan 18 | vs Mercer | W69-49 | 10-9 | .526 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 20 | Wed Jan 22 | vs The Citadel | W79-68 | 11-9 | .550 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 21 | Sat Jan 25 | at Samford | L61-77 | 11-10 | .524 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 22 | Wed Jan 29 | vs VMI | L67-74 | 11-11 | .500 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 23 | Sat Feb 1 | atUNC Greensboro | W74-62 | 12-11 | .522 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 24 | Wed Feb 5 | vsChattanooga | L70-79 | 12-12 | .500 | - | ESPNU | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 25 | Sat Feb 8 | atMercer | W77-66 | 13-12 | .520 | - | ESPN+ | Hawkins Arena · Macon, GA |
| 26 | Wed Feb 12 | atThe Citadel | W74-71 (OT) | 14-12 | .538 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 27 | Sat Feb 15 | vsSamford | L68-76 | 14-13 | .519 | - | ESPNU | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 28 | Wed Feb 19 | atVMI | W82-43 | 15-13 | .536 | - | ESPN+ | Cameron Hall · Lexington, VA |
